Pentraxin-3 gene expression in cumulus cells may be a molecular marker for egg quality

Zhang, Xingqi J; Moyse, Jill; Jarari, Nadereh; Confino, Edmond; Kazer, Ralph R.

doi:10.1016/s0015-0282(03)02016-8

Cited by 3 publications

(2 citation statements)

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“…39,40 Along the same line of evidence, the relative expression of a gene, such as pentraxin 3, by cumulus cells appeared to be associated with the developmental potential of the oocyte. 41 With respect to follicle cell function and its relative impact on oocyte quality, evidence remains correlative and is mostly limited to single studies with no analyses in large-scale, randomized, well-controlled, and prospective clinical studies. Lastly, although correlations exist between levels of apoptosis in cumulus or granulosa cells and cycle variables (patient age, stimulation, or even pregnancy outcome), there is no evidence for cell apoptosis constituting a prognostic marker of individual oocyte quality.…”

Section: Assessment Of Oocyte Qualitymentioning

confidence: 99%

Assessment and Optimization of Oocyte Quality during Assisted Reproductive Technology Treatment

Combelles

Racowsky

2005

Semin Reprod Med

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The health of fetuses, neonates, and adults depends on normal development of the oocytes and embryos from which they arise. In addition, the ability of an embryo to implant, sustain a pregnancy, and give rise to a viable offspring is unquestionably rooted in oogenesis. Therefore, defining markers that can reliably predict the best quality oocytes will prove invaluable in the care and management of infertility patients. Furthermore, identification of the best quality oocyte will also permit the transfer of a single embryo, thereby increasing overall pregnancy rates and reducing multiple rates. Although a few potentially important predictors of oocyte quality have been identified, their application for routine use in the assisted reproductive technology (ART) laboratory remains to be established. With the critical need for markers to be noninvasive, reliable, and assayable with a rapid turnaround, key areas that will take advantage of recent technological advances are identified in this article. Oocyte quality also needs to be improved in the management of human infertility by ART programs. Given that mechanisms determining oocyte quality are multifactorial and complex, several possible areas that continue to necessitate optimization are discussed.

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Section: Assessment Of Oocyte Qualitymentioning

confidence: 99%

Assessment and Optimization of Oocyte Quality during Assisted Reproductive Technology Treatment

Combelles

Racowsky

2005

Semin Reprod Med

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“…On the other hand, real-time polymerase chain reaction (PCR) offers substantial advantages over conventional reverse transcriptase – polymerase chain reaction (RT-PCR) for the molecular study of gene expression in any kind of cell, including cumulus cells. Some studies have investigated gene expression by means of real-time PCR using a large number of cumulus cells [ 10 , 11 ] collected from many COCs, since it is difficult to develop a template for investigating gene expression. Only a few gene expressions have been revealed in cumulus cells during oocyte maturation due to the very small number of cumulus cells surrounding an oocyte.…”

Section: Introductionmentioning

confidence: 99%

Easy and rapid method for the determination of gene expression in cumulus cells incubated for oocyte maturation

Kumamoto

Wang

Yamashiro

et al. 2005

Reprod Biol Endocrinol

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Pentraxins at the Crossroads Between Innate Immunity, Inflammation, Matrix Deposition, and Female Fertility

Garlanda

Bottazzi

Bastone

et al. 2005

Annu. Rev. Immunol.

772

807

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C reactive protein, the first innate immunity receptor identified, and serum amyloid P component are classic short pentraxins produced in the liver. Long pentraxins, including the prototype PTX3, are expressed in a variety of tissues. Some long pentraxins are expressed in the brain and some are involved in neuronal plasticity and degeneration. PTX3 is produced by a variety of cells and tissues, most notably dendritic cells and macrophages, in response to Toll-like receptor (TLR) engagement and inflammatory cytokines. PTX3 acts as a functional ancestor of antibodies, recognizing microbes, activating complement, and facilitating pathogen recognition by phagocytes, hence playing a nonredundant role in resistance against selected pathogens. In addition, PTX3 is essential in female fertility because it acts as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. Thus, the prototypic long pentraxin PTX3 is a multifunctional soluble pattern recognition receptor at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility.

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Pentraxin-3 gene expression in cumulus cells may be a molecular marker for egg quality

Cited by 3 publications

References 0 publications

Assessment and Optimization of Oocyte Quality during Assisted Reproductive Technology Treatment

Assessment and Optimization of Oocyte Quality during Assisted Reproductive Technology Treatment

Easy and rapid method for the determination of gene expression in cumulus cells incubated for oocyte maturation

Pentraxins at the Crossroads Between Innate Immunity, Inflammation, Matrix Deposition, and Female Fertility

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