Pentraxin 3 and Platelet Activation in Obese Patients After Gastric Banding

Santilli, Francesca; Guagnano, Maria Teresa; Innocenti, Paolo; Aceto, L; Vazzana, Natale; Lattanzio, Stefano; Liani, Rossella; Tripaldi, Romina; Creato, Valeria; Romano, Mario; Davı̀, Giovanni

doi:10.1253/circj.cj-15-0721

Cited by 15 publications

(11 citation statements)

References 44 publications

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“…28 In terms of the relationship between PTX3 and platelet reactivity, Santilli et al conducted a 12-month longitudinal study to test the hypothesis that laparoscopic adjustable gastric banding-induced weight loss was associated with changes in platelet activation markers and PTX3. 16 They reported that the reduction in inflammation, insulin resistance, and thromboxane biosynthesis associated with laparoscopic adjustable gastric banding is paralleled by an increase in plasma PTX3, which remains a significant predictor of thromboxane metabolite excretion during 1-year follow-up. 16 Pentraxin 3 was inversely related to platelet activation markers, 11-dehydro-thromboxane B2 and CD40 L. Moreover, multiple regression analysis demonstrated that plasma PTX3 was an independent predictor of urinary 11-dehydro-thromboxane B2 excretion.…”

Section: Discussionmentioning

confidence: 99%

“…However, there are conflicting reports on the effects of PTX3 in the cardiovascular system since several studies demonstrate cardioprotective actions of PTX3 while others argue that the elevated PTX3 plasma levels in patients with cardiovascular conditions correlate with disease severity and poor prognosis. 13,15,16 Pentraxin 3 levels probably reflect an acute inflammatory response to acute atherothrombosis, thus identifying patients at higher risk of a negative outcome. 12,15 More research is required to better understand the role of PTX3 and platelets activation.…”

Section: Discussionmentioning

confidence: 99%

“…15 Moreover, PTX3 is inversely related to platelet activation markers. 16 Most clinical studies have used sophisticated platelet function test. However, the methods of testing platelet activity may be very time-consuming, expensive, and technically difficult.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Plasma Pentraxin 3 Concentration and Platelet Indices in Patients With Stable Coronary Artery Disease

et al. 2017

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Few reports have analyzed the effect of pentraxin 3 (PTX3) on platelets and their activation. We explored the association between plasma PTX3 and platelet indices. Forty-nine patients with stable coronary artery disease (CAD) were enrolled. Based on median PTX3, the study population was divided into group 1 (n = 25; PTX3 ≤ 0.98 ng/mL) and group 2 (n = 24; PTX3 > 0.98 ng/mL). Platelet indices investigated included mean platelet volume (MPV), platelet distribution width (PDW), platelets and large cell ratio (P-LCR), MPV to platelet count ratio (MPV/PC), platelet to lymphocyte ratio (PLR), and MPV to lymphocyte ratio (MPVLR). Patients with lower PTX3 had a higher lymphocyte count. Platelet count was similar in both groups. Notwithstanding, patients with higher PTX3 concentrations had elevated MPV (8.3 vs 10.0 fL; P < .001) and PDW (9.4 vs 12.4 fL; P < .001). However, the MPV/PC ratio was similar in both groups. Thromboinflammatory biomarkers (PLR, MPVLR) were also elevated in group 2. Pentraxin 3showed a strong, positive correlation with MPV ( r = .75, P < .01) and PDW ( r = .80, P < .01), and weak to moderate correlation with MPVLR. In conclusion, PTX3 is associated with larger platelet size as assessed by platelet volume indices. There is a strong correlation between plasma PTX3 level and MPV and PDW.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Relationship Between Plasma Pentraxin 3 Concentration and Platelet Indices in Patients With Stable Coronary Artery Disease

et al. 2017

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“…These results are in agreement with previous studies from Ogawa et al (9) and Osorio-Conles et al (10), who both found an inverse association between the serum blood levels of PTX3 and BMI. In addition, PTX3 serum levels are increased in obese patients who underwent dietary intervention (11) and gastric banding (7). There was no association between PTX3 levels and the lipid profile or the glycemic controls; however, the elevation of this biomarker itself is of interest for patients undergoing bariatric surgery as it has been shown that PTX3 may exert a protective role on the cardiovasculature (12).…”

Section: Discussionmentioning

confidence: 99%

Bariatric surgery results in restoration of physiological plasma levels of pentraxine‑3

Tonial

Nisihara²,

Nassif

et al. 2019

biom rep

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Pentraxine-3 (PTX3) is a member of the humoral innate immune system and serves a role in protection against infections, inflammation control and matrix deposition. The aim of the present study was to measure the PTX3 levels in obese patients and its association with glycemic and lipid profiles, and to analyze the effects of weight loss provided by bariatric surgery in serum PTX3 levels. PTX3 was measured in 84 obese patients whom underwent bariatric surgery and 94 healthy controls. Lipid and glycemic profiles were determined using a clinical chemistry analyzer, and PTX3 levels were measured in patients prior to and following bariatric surgery using ELISA. PTX3 levels prior to surgery were significantly lower compared with the normal controls (median of 0.10 vs. 0.80 ng/ml; P<0.0001). Following surgery, the median weight loss was 33.1 kg, and the median PTX3 levels were significantly increased to 1.45 ng/ml compared with pre-surgery levels (P<0.001) and did not differ significantly from the control group levels (P=0.10). There were no correlations between PTX3 levels and total cholesterol, HDL and LDL, fasting glycemia, HbA1c and basal insulin levels. A significant positive correlation was observed between PTX3 levels and triglycerides levels in the post-operative period (ρ= 0.26, P= 0.01). In conclusion, obese patients had lower levels of PTX3 compared with the control patients, and the levels were restored to physiological levels following bariatric surgery which may be associated with the weight loss.

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“…W badaniach wykazano, że PTX3 uwalniana ze zaktywowanych neutrofilów pod wpływem mediatorów stanu zapalnego w reakcji na uszkodzenie, na przykład niedokrwienie, wiąże się z płytkami krwi, uniemożliwiając w ten sposób tworzenie się agregatów płytkowych, które osłabiają przepływ krwi w mikrokrążeniu [30]. Udowodniono, że PTX3 koreluje odwrotnie proporcjonalnie z markerami aktywacji płytek, między innymi 11-dehydro-tromboksanem B 2 , co może świadczyć o tym, że PTX3 cechują właściwości przeciwpłytkowe, przez co może chronić przed niedokrwieniem [31].…”

Section: Pentraksyna 3 a Blaszki Miażdżycoweunclassified

Pentraksyna 3 jako niezależny marker rozwoju choroby wieńcowej, stopnia jej zaawansowania oraz rokowania

et al. 2017

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Pentraxin 3 and Platelet Activation in Obese Patients After Gastric Banding

Cited by 15 publications

References 44 publications

Relationship Between Plasma Pentraxin 3 Concentration and Platelet Indices in Patients With Stable Coronary Artery Disease

Relationship Between Plasma Pentraxin 3 Concentration and Platelet Indices in Patients With Stable Coronary Artery Disease

Bariatric surgery results in restoration of physiological plasma levels of pentraxine‑3

Pentraksyna 3 jako niezależny marker rozwoju choroby wieńcowej, stopnia jej zaawansowania oraz rokowania

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