Pentoxifylline in Acute Ischemic Stroke Patients With Blood Hyperviscosity

Abstract

Objective: This study evaluated the efficacy of pentoxifylline, a hemorrheologic agent, for treating acute ischemic stroke in patients with blood hyperviscosity. Methods:Patients were randomly allocated within 3 days of stroke onset to study or control treatment. All the patients received the standard acute ischemic stroke treatment. The study treatment was intravenous pentoxifylline 1200 mg/day for 5 consecutive days and oral pentoxifylline 800 mg in two divided doses for 23 days. Blood viscosity was evaluated on days 7 and 30. The outcomes were assessed by the National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale, and Barthel index (BI) criteria. Results:The median baseline viscosity was 6.89 poise in the study and 6.46 poise in the control groups and had decreased in all the patients on days 7 and 30. The decrease in the study group on day 7 (1.13 poise) was greater than that in the control group (0.57 poise); the difference was not significant. The NIHSS score improved by 32% in the study group (relative risk [RR]=1.00, 95% confidence interval [CI]: 0.421-3.556; p=1.00). At 1-month, 67% of the study group had a good functional outcome (RR=1.026, 95% CI: 0.656-1.605; p=0.909). Conclusion:Pentoxifylline decreased blood viscosity and improved clinical outcome in this patient series.

Fibrinogen and LDL Influence on Blood Viscosity and Outcome of Acute Ischemic Stroke Patients in Indonesia

“…“Digital Microcapillary” is a novel diagnostic instrument created by Al Rasyid et al and has been patented in Indonesia by the Ministry of Law and Human Rights of Republic of Indonesia since 2016. 18 Digital microcapillary is a simple portable device to measure blood viscosity rapidly and cheaply. The use of this novel digital microcapillary instrument is an advantage of this study because it has not been used in any previous studies.…”

The Reasons Acute Stroke Patients Not Receiving Thrombolysis in an Indonesian Referral Hospital

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Profil Pasien Stroke Iskemik Akut Dengan Terapi Recombinant Tissue Plasminogen Activator Di Rsup Dr. Kariadi Semarang

“…Implementasi perawatan dalam stroke (SITS), pasien trombolisis, skor 0-2 pada mRS hari 90 pasca-trombolisis menggambarkan independensi fungsional yang terjadi pada 55,4% subjek. [32][33] Terdapat 1 subjek (2,7%) meninggal yang disebabkan komplikasi symptomatic intracerebral hemorrhage (sICH). Hal ini kemungkinan disebabkan karena kondisi hiperglikemia pada pasien saat di IGD dengan latar belakang diabetes melitus tidak terkontrol yang dapat menjadi salah satu faktor risiko terjadinya sICH.…”

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