Fibrinogen and LDL Influence on Blood Viscosity and Outcome of Acute Ischemic Stroke Patients in Indonesia

Rasyid, Al; Harris, Salim; Kurniawan, Mohammad; Mesiano, Taufik; Hidayat, Rakhmad

doi:10.1177/0972753119900630

Cited by 17 publications

(19 citation statements)

References 10 publications

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“…There have been many studies reporting increases in blood viscosity to be an independent risk factor [18,19]. Parameters such as dyslipidemia, DM, smoking, hematocrit level, erythrocyte deformability and fibrinogen all affect blood viscosity [20]. In the present study, fibrinogen levels were higher in Group 2 than in Group 1, and the between-group difference was statistically significant.…”

Section: Discussionsupporting

confidence: 51%

The effect of preprocedural serum albumin to fibrinogen ratio on arteriovenous fistula maturation

Akgül¹,

Özhan²

2021

Journal of Surgery and Medicine

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Section: Discussionsupporting

confidence: 51%

The effect of preprocedural serum albumin to fibrinogen ratio on arteriovenous fistula maturation

Akgül¹,

Özhan²

2021

Journal of Surgery and Medicine

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“…We also suggest that high concentration of fibrinogen (which translates as increase in the activation of platelets) may be a risk factor for low serum concentrations of vitamin D less than 50 nmol/L in ischemic stroke patients. To the best of our knowledge, this is the first study to report on high concentration of fibrinogen being a risk factor for vitamin D deficiency in ischemic stroke; besides, it has been reported that high levels of FIB will increase plasma viscosity, which may lead to low cerebral blood flow and impaired perfusion ultimately leading to a higher severity of stroke ( Rasyid et al, 2019 ; Tao et al, 2020 ). This may explain why NIHSS is more sensitive to the vitamin D deficiency group with high FIB level.…”

Section: Discussionmentioning

confidence: 81%

Risk Factors of Vitamin D Deficiency in Chinese Ischemic Stroke Patients: A Cross-Sectional Study

Miao

Zhu

Luan

et al. 2021

Front. Aging Neurosci.

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PurposeLower serum vitamin D has been reported to be associated with stroke. This study aimed to analyze the risk factors of vitamin deficiency in Chinese stroke patients, and further analyze its impact in different gender and their clinical variables.Methods982 stroke patients were enrolled. Laboratory parameters such as serum vitamin D, apolipoprotein A-I (ApoA-I), apolipoprotein B (ApoB), ApoA-I/ApoB, cholesterol (CH), fibrinogen (FIB), blood glucose (Glu), high-density lipoprotein (HDL), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) were collected and recorded. The severity of stroke was assessed by National Institute of Health Stroke Scale (NIHSS) score. Based on their serum vitamin D level, patients were divided into three groups: Vitamin D deficiency (<50 nmol/L), vitamin D insufficiency (≥50–75 nmol/L) and vitamin D sufficiency (≥75 nmol/L) and differences were compared among the three groups. Statistical analyses were done to assess the risk factors for serum vitamin D deficiency in our ischemic stroke patients.ResultsGender, NIHSS, and FIB showed significant differences among the vitamin D groups (P < 0.001 ∼ P = 0.002). The female gender (OR = 2.422, P < 0.001), severity of stroke using NIHSS (OR = 1.055, P = 0.008) and FIB (OR = 1.256, P = 0.005) were risk factors of vitamin D deficiency in ischemic stroke patients. In subgroup analysis, NIHSS was significantly associated with vitamin D deficiency in the male group (OR = 1.087, P = 0.002) and higher FIB group (OR = 1.078, P = 0.001).ConclusionsThe female gender, severity of stroke using NIHSS and FIB were risk factors for vitamin D deficiency in our incident stroke patients. NIHSS was more sensitive to vitamin D deficiency in male ischemic stroke patients. Besides, under higher FIB circumstance, the increasing NIHSS score was more related to the vitamin D deficiency. Levels of vitamin D in patients with ischemic stroke should be well monitored during the disease cascade.

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“…16 In addition, there are other studies that state fibrinogen is a factor that independently affects blood viscosity in a population of acute ischemic stroke patient. 8 Other studies state that the higher the blood viscosity, the greater vascular resistance, resulting in an increase PI value. 17…”

Section: Discussionmentioning

confidence: 99%

“…These characteristics causes high levels of fibrinogen will increase blood viscosity. 8 One of the Transcranial Doppler (TCD) parameters is the Pulsatility Index (PI) which evaluates the peripheral resistance of blood vessels. 9 The most important factors Medico-legal Update, October-December 2021, Vol.21, No.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Fibrinogen Level with Middle Cerebral Artery Pulsatility Index in Acute Ischemic Stroke

Tikha¹,

Setyowatie²,

Hamdan³

et al. 2021

MLU

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Background: High levels of fibrinogen will increase the blood viscosity. Pulsatility index parameter in transcranial doppler can measure blood vessel resistance which influence by cerebral blood flow velocity and blood viscosity. This study has aim to find correlation between fibrinogen with PI in acute thrombotic stroke patient. Method:A cross sectional design was used in this study. The samples were patient with acute ischemic stroke in neurological ward Dr. Soetomo Hospital Surabaya from January 2019 to December 2020. Fibrinogen level was measured using clauss method. PI was calculated by peak systolic velocity, end diastolic velocity and mean vessel velocity, which were measured in middle cerebral artery.Result: This study involved 32 samples consisted 22 males and 10 females. Mean age of subjects was 55.37 ± 10.55. The mean fibrinogen level is 356.95 ± 139.57. Mean MCA PI is 1.03 ±0.34. There is positive correlation with weak correlation strength between fibrinogen level with MCA PI in acute thrombotic stroke patients and statistically significant (p=0.024, r=0.398). Conclusion:There is a positive correlation between fibrinogen level with PI MCA in acute thrombotic stroke.

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Fibrinogen and LDL Influence on Blood Viscosity and Outcome of Acute Ischemic Stroke Patients in Indonesia

Cited by 17 publications

References 10 publications

The effect of preprocedural serum albumin to fibrinogen ratio on arteriovenous fistula maturation

The effect of preprocedural serum albumin to fibrinogen ratio on arteriovenous fistula maturation

Risk Factors of Vitamin D Deficiency in Chinese Ischemic Stroke Patients: A Cross-Sectional Study

Correlation between Fibrinogen Level with Middle Cerebral Artery Pulsatility Index in Acute Ischemic Stroke

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