Pentoxifylline attenuates nociceptive sensitization and cytokine expression in a tibia fracture rat model of complex regional pain syndrome

Wei, Tzuping; Sabsovich, Ilya; Guo, Tian-Zhi; Shi, Xiaoshuang; Zhao, Rong; Li, Wenwu; Geis, Christian; Sommer, Claudia; Kingery, Wade S.; Clark, David J.

doi:10.1016/j.ejpain.2008.04.014

Cited by 58 publications

(77 citation statements)

References 66 publications

(91 reference statements)

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“…This effect is possibly due to the reduction of the formation of endoperoxides as a consequence of the elevated cAMP levels that inhibit the cyclooxygenase within the arachidonic pathway (29). Furthermore, it is been shown that pentoxifylline both enhances morphine's analgesic effects by targeting microglial activation during morphine therapy/ treatment in mice (30) and also decreases pro-infl ammatory cytokines contributing to nociceptive in rats (31).…”

Section: Discussionmentioning

confidence: 99%

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Moradi¹,

Mahmoodi²,

Raoofi³

et al. 2015

BLL

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Abstract:Background: Knowledge about harmful effects of morphine on hormone secretion seems to be necessary. The aim of the present study was to evaluate the effect of pentoxifylline on side effects derived by morphine on hypophyso-gonadal hormones of male rats. Methods: 32 male rats were divided into the 4 groups of OSS: control (received 40 g Sucrose/l drinking water and intraperitoneal injection of 1 l/kg normal saline), OMS: morphine group (received 0.4 mg/l + 40 g Sucrose/l in drinking water and intraperitoneal injection of 1 l/kg normal saline), NMS: morphine+naltrexane group (received 0.4 mg/l + 40 g Sucrose/l in drinking water and IP injection dose of 10 mg/kg/ml/day Naltrexane) and PMS: morphine + pentoxifylline group (received 0.4 mg/dl + 40 g Sucrose/l in drinking water and IP injection dose of 12 mg/kg/ml/day Pentoxifylline) for 56 days, respectively. Results: Serum levels of testosterone, LH, FSH hormones were measured. Pentoxifylline increased serum levels of testosterone, LH, FSH hormones compared to control, morphine and morphine-naltrexane groups. Conclusion: Pentoxifylline has a signifi cant effi cacy for increasing serum levels of sexual hormones. Considering that Pentoxifylline is safe and cheap, with easy application, we suggest for the usage of this drug for improving semen parameter's quality before performing ART for the treatment of morphine addicts (Fig. 1, Ref. 31). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 99%

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Moradi¹,

Mahmoodi²,

Raoofi³

et al. 2015

BLL

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“…As stated earlier, substance P activation also leads to the over-expression of the inflammatory cytokines (Wei et al, 2009), for example, nerve growth factor is one of the cytokines that leads to osteopenia. The use of a nerve growth factor antibody not only reduced nociception but to a modest degree, maintained further bone loss in the distal trabecular bone (Sabsovich et al, 2008).…”

Section: Neuropeptide Modulatorsmentioning

confidence: 99%

“…The use of a nerve growth factor antibody not only reduced nociception but to a modest degree, maintained further bone loss in the distal trabecular bone (Sabsovich et al, 2008). Pentoxifylline, a cytokine inhibitor, was used to evalute its effect in trabecular bone loss (Wei et al, 2009). Pentoxifylline had significant effects in the fracture induced up-regulation of inflammatory cytokines and reversed nociceptive sensitization and vascular abnormalities.…”

Section: Neuropeptide Modulatorsmentioning

confidence: 99%

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Patchy Osteoporosis in Complex Regional Pain Syndrome

Park¹,

Im²,

Lim³

2012

Osteoporosis

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“…Pentoxifylline (PTX) is a nonselective phosphodiesterase inhibitor that is further known for its broad-spectrum cytokine inhibitory properties [Wei et al 2009;Lin et al 2010]. It has been used clinically in a wide variety of conditions.…”

Section: Growth Factorsmentioning

confidence: 99%

Optimizing postoperative sexual function after radical prostatectomy

Tutolo

Briganti

Suardi

et al. 2012

Therapeutic Advances in Urology

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Erectile dysfunction (ED) is one of the complications associated with pelvic surgery. The significance of ED as a complication following pelvic surgery, especially radical prostatectomy (RP), lies in the negative impact that it has on patients' sexual and overall life. In the literature, rates of ED following RP range from 25% to 100%. Such variety is associated with pelvic dissection and conservation of neurovascular structures. Another important factor impacting on postoperative ED is the preoperative erectile function of the patient. Advances in the knowledge of pelvic anatomy and pathological mechanisms led to a refinement of pelvic surgical techniques, with attention to the main structures that if damaged compromise erectile function. These improvements resulted in lower postoperative ED rates and better erectile recovery, especially in patients undergoing RP. Furthermore, surgery alone is not sufficient to prevent this complication, and thus, several medical strategies have been tested with the aim of maximizing erectile function recovery. Indeed it seems that prevention of postoperative ED must be addressed by a multimodal approach. The aim of this review is to give a picture of recent knowledge, novel techniques and therapeutic approaches in order to reach the best combination of treatments to reduce the rate of ED after pelvic surgery.

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Pentoxifylline attenuates nociceptive sensitization and cytokine expression in a tibia fracture rat model of complex regional pain syndrome

Cited by 58 publications

References 66 publications

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Patchy Osteoporosis in Complex Regional Pain Syndrome

Optimizing postoperative sexual function after radical prostatectomy

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