Pentoxifylline alleviated cardiac injury via modulating the cardiac expression of lncRNA-00654-miR-133a-SOX5 mRNA in the rat model of ischemia-reperfusion

Matboli, Marwa; Habib, Eman K.; Mohamed, Reham Hussein; Mahran, Nievin Ahmed; Seleem, Hanan S.; Nosseir, Nermine; Hasanin, Amany Helmy

doi:10.1016/j.biopha.2020.109842

Cited by 7 publications

(7 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Xu et al showed that LINC00654 is one of the lncRNAs with high diagnostic performance for CRC (11), and LINC00654 upregulation is also associated with poor breast cancer OS (8). Matboli et al also showed that pentoxifylline can alleviate cardiac injury using the lncRNA-00654-miR-133a-SOX5 mRNA network (12).…”

Section: Discussionmentioning

confidence: 99%

“…These downstream target genes were also predicted through batch survival analysis and expression validation, and the LINC00654-NINL mRNA regulatory axis was identified. LINC00654 is located on chromosome 20p12.3 and is reported as a risk lncRNA in several cancers (8,11,12). However, the role of LINC00654 and its regulatory network in the progression of DLBCL remains unknown.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Identification of LINC00654-NINL Regulatory Axis in Diffuse Large B-Cell Lymphoma In Silico Analysis

Chen

Wang

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

BackgroundThe long non-coding RNA (lncRNA)-mRNA regulation network plays an important role in the development of diffuse large B-cell lymphoma (DLBCL). This study uses bioinformatics to find an innovative regulation axis in DLBCL that will provide a positive reference for defining the mechanism of disease progression.MethodsBatch Cox regression was used to screen prognosis-related lncRNAs, and a random forest model was used to identify hub lncRNA. The clinical value of the lncRNA was evaluated and Spearman correlation analysis was used to predict the candidate target genes. Gene Oncology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were used to define the biological function of the lncRNA. A batch Cox regression model, expression validation, and Spearman correlation analysis were used to select the best downstream target genes. The expression and prognostic value validation of this gene was conducted using public data. Gene Set Enrichment Analysis (GSEA) was performed to explore potential mechanisms for this gene in DLBCL.ResultsLINC00654 was identified as the hub lncRNA and 1443 mRNAs were selected as downstream target genes of the lncRNA. The target genes were enriched in the regulation of GTPase and Notch signaling pathways. After validation, the ninein-like (NINL) gene was selected as the potential target of LINC00654 and the LINC00654-NINL axis was constructed. Patients with better responses to therapy were shown to have high NINL gene expression (p-value = 0.036). NINL also had high expression in the DB cell line and low expression in the OCILY3 cell line. Survival analysis showed that high NINL expression was a risk factor for overall survival (OS) and disease-specific survival (DSS) within older patients and those with advanced-stage cancer. GSEA results showed that NINL may be involved in neutrophil-mediated immunity and NF-κB signaling.ConclusionThis study identified a novel LncRNA00654-NINL regulatory axis in DLBCL, which could provide a favorable reference for exploring the possible mechanisms of disease progression.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification of LINC00654-NINL Regulatory Axis in Diffuse Large B-Cell Lymphoma In Silico Analysis

Chen

Wang

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Matboli et al showed similar improvements in the cardiac structure in a rat model of ischemia-reperfusion, upon PTX treatment. 94 Our study showed for the first time that Van and PTX combination has more beneficial effects in ameliorating cardiac injury compared to monotherapy and ramipril. Combined therapy was more effective in promoting angiogenesis and reducing cardiac oxidative stress, inflammation and apoptosis.…”

Section: Food and Function Papermentioning

confidence: 64%

“…Matboli et al showed similar improvements in the cardiac structure in a rat model of ischemia-reperfusion, upon PTX treatment. 94…”

Section: Discussionmentioning

confidence: 99%

Vanillin and pentoxifylline ameliorate isoproterenol-induced myocardial injury in rats via the Akt/HIF-1α/VEGF signaling pathway

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Pentoxifylline (PTXF) is a xanthine derivative that has several biological activities such as anti-inflammatory and antioxidant effects, in addition to improving the blood rheological properties (Wen et al 2017 ). In a rat model of ischemia/reperfusion, Matboli et al showed that PTXF administration resulted in enhancements in cardiac structure and function (Matboli et al 2020 ). Moreover, Dhulqarnain et al .…”

Section: Introductionmentioning

confidence: 99%

Enhancement of cardiac angiogenesis in a myocardial infarction rat model using selenium alone and in combination with PTXF: the role of Akt/HIF-1α signaling pathway

Elseweidy,

Ali,

Shaheen

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Ischemic heart diseases such as myocardial infarction (MI) are a global health problem and a leading cause of mortality worldwide. Angiogenesis is an important approach for myocardial healing following ischemia. Thus, this study aimed to explore the potential cardiac angiogenic effects of selenium (Se), alone and in combination with the tumor necrosis factor-alpha inhibitor, pentoxifylline (PTXF), via Akt/HIF-1α signaling. MI was induced in rats using two subcutaneous doses of isoprenaline (ISP) at a 24-h interval (150 mg/kg). One week later, rats were orally given Se (150 µg/kg/day), PTXF (50 mg/kg/day), or Se/PTXF combination. ISP-induced myocardial damage was evident by increased HW/TL ratios, ST segment elevation, and increased serum levels of CK-MB, LDH, and troponin-I. ISP increased the cardiac levels of the lipid peroxidation marker MDA; the pro-inflammatory cytokines IL-6, IL-1β, and TNF-α; and the pro-apoptotic protein Bax and caspase-3. In contrast, the cardiac levels of the antioxidant markers GSH and SOD and the anti-apoptotic marker Bcl-2 were reduced. Furthermore, ISP markedly increased the cardiac levels of p-Akt and HIF-1α proteins and the cardiac gene expression of ANGPT-1, VEGF, and FGF-2. Treatment with Se both alone and in combination with PTXF ameliorated the ISP-induced myocardial damage and further increased cardiac angiogenesis via Akt/HIF-1α signaling. Se/PTXF combined therapy was more beneficial than individual treatments. Our study revealed for the first time the cardiac angiogenic effects of Se both alone and in combination with PTXF in myocardial infarction, suggesting that both may be promising candidates for clinical studies. Graphical Abstract

show abstract

Pentoxifylline alleviated cardiac injury via modulating the cardiac expression of lncRNA-00654-miR-133a-SOX5 mRNA in the rat model of ischemia-reperfusion

Cited by 7 publications

References 48 publications

Identification of LINC00654-NINL Regulatory Axis in Diffuse Large B-Cell Lymphoma In Silico Analysis

Identification of LINC00654-NINL Regulatory Axis in Diffuse Large B-Cell Lymphoma In Silico Analysis

Vanillin and pentoxifylline ameliorate isoproterenol-induced myocardial injury in rats via the Akt/HIF-1α/VEGF signaling pathway

Enhancement of cardiac angiogenesis in a myocardial infarction rat model using selenium alone and in combination with PTXF: the role of Akt/HIF-1α signaling pathway

Contact Info

Product

Resources

About