Pentose metabolism in candida albicans. I. The reduction of D-xylose and L-arabinose

Veiga, L.A.; Bacila, Metry; Horecker, B.L.

doi:10.1016/0006-291x(60)90145-5

Cited by 46 publications

(10 citation statements)

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“…32 Ab-initio simulations using the FDMNES code also show negligible leading edge shift for a hypothetical Sr 2 RhO 4 structure with compressed lattice parameters. 33 While K-edge shifts may be influenced by structural relaxation effects 34,35 we have no evidence that indicates Fig. 1(b).…”

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confidence: 78%

Charge partitioning and anomalous hole doping in Rh-doped Sr2IrO4

et al. 2017

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The simultaneous presence of sizable spin-orbit interactions and electron correlations in iridium oxides has led to predictions of novel ground states including Dirac semimetals, Kitaev spin liquids, and superconductivity. Electron and hole doping studies of spin-orbit assisted Mott insulator Sr2IrO4 are being intensively pursued due to extensive parallels with the La2CuO4 parent compound of cuprate superconductors. In particular, the mechanism of charge doping associated with replacement of Ir with Rh ions remains controversial with profound consequences for the interpretation of electronic structure and transport data. Using x-ray absorption near edge structure (XANES) measurements at the Rh L, K-and Ir L-edges we observe anomalous evolution of charge partitioning between Rh and Ir with Rh doping. The partitioning of charge between Rh and Ir sites progresses in a way that holes are initially doped into the J eff =1/2 band at low x only to be removed from it at higher x values. This anomalous hole doping naturally explains the reentrant insulating phase in the phase diagram of Sr2Ir1−xRhxO4 and ought to be considered when searching for superconductivity and other emergent phenomena in iridates doped with 4d elements.

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confidence: 78%

Charge partitioning and anomalous hole doping in Rh-doped Sr2IrO4

et al. 2017

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“…The NAD-coupled polyol dehydrogenase system of S. commune catalyzes the oxidation of xylitol, mannitol, and sorbitol, and is favored in alkaline medium. Similar systems have been described in Candida utilis (Arcus and Edson, 1956;Chakravorty et al, 1962), C. albicans (Veiga, Bacila, and Horecker, 1960), and Penicillium chrysogenum (Chiang and Knight, 1959). In comparison, the NAD-dependent polyol dehydrogenase of Piricularia oryzae (Yamada et al, 1961) and Coccidioides immitis (Lones and Peacock, 1964) functions at the level of phosphorylated intermediates in the conversion of fructose-6-phosphate to mannitol-1-phosphate, whereas the reduction of fructose to mannitol in A. campestris (Edmundowicz and Wriston, 1963) and Geotrichum candidum (Shu-Cheng and Kao-Hsiang, 1964) requires NADPH2.…”

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confidence: 64%

Polyol Metabolism in the Basidiomycete Schizophyllum commune

1965

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The polyol metabolism of intact cells and extracts of the wood-rotting mushroom Schizophyllum commune was investigated during the developmental cycle. Exogenous polyols stimulated the cellular respiration of germlings, but were without effect on that of ungerminated basidiospores. Requisite enzymes of polyol metabolism were demonstrated in extracts of spores and of subsequent stages of development. Oxidation of mannitol and sorbitol appeared to be coupled to nicotinamide adenine dinucleotide (NAD) reduction and was favored in alkaline medium. Ketohexose formation was shown during mannitol oxidation, and the NADdependent oxidation of xylitol yielded ketopentose. Xylitol oxidation with nicotinamide adenine dinucleotide phosphate (NADP) as hydrogen acceptor led to pentose formation. Oxidation of reduced NAD was enhanced by fructose but not by sorbose. Reduction of aldohexose and pentose was dependent upon reduced NADP, and pentose reductase was maximal at pH 6.8. The specific activity of mannitol dehydrogenase was highest in extracts of vegetative mycelium. Growth in either glucose or xylose media had no significant effect on enzymes of polyol metabolism.

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“…The respective reduction of D-xylose and L-arabinose to xylitol and Larabitol by an NADP-linked enzyme was found by VEIGA et al (1)(2)(3)(4) in cellfree extracts of Candida albicans grown in the presence of D-xylose. Reports from CHIANG and KNIGHT (5) and HERS (6), on the other hand, involved aldose reductases respectively from filamentous fungus and seminal vesicle.…”

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confidence: 77%

“…The enzymatic oxidation of xylitol to D-xylulose by a non-specific NADlinked polyol dehydrogenase was also found in Candida albicans by VEIGA et al (1)(2)(3)(4).…”

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confidence: 79%

Polyol Dehydrogenases in Candida Albicans

Veiga

1968

J. Gen. Appl. Microbiol.

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Candida albicans grown in a liquid medium containing 0.5% D-xylose produced an adaptative NADP-polyol dehydrogenase which catalyzes the reversible reduction of some aldoses to the corresponding polyols. This enzyme was extracted from the culture and purified 134-fold using ammonium sulfate precipitations followed by calcium phosphate gel column chromatography. The Michaelis constant for D-xylose was determined to be 6.7 X 10 M. Heating of the enzyme up to 43° enhanced its activity, but it became completely inactive at 65°.The respective reduction of D-xylose and L-arabinose to xylitol and Larabitol by an NADP-linked enzyme was found by VEIGA et al.(1-4) in cellfree extracts of Candida albicans grown in the presence of D-xylose. Reports from CHIANG and KNIGHT (5) and HERS (6), on the other hand, involved aldose reductases respectively from filamentous fungus and seminal vesicle. MORET and SPERTI (7) showed the presence of a similar enzyme in Oospora lactis.The enzymatic oxidation of xylitol to D-xylulose by a non-specific NADlinked polyol dehydrogenase was also found in Candida albicans by VEIGA et al. (1-4). CHAKRAVORTY et al. (8) determined a similar enzyme in C. utilis, and CHIANG and KNIGHT (5) in a filamentous fungus. FOSSIT et al. (9) presented the data which indicates that Aerobacter aerogenes metabolizes xylitol through the route common to the other organisms, but a different sequence is involved in the metabolism of L-arabitol.Two xylitol dehydrogenases were determined by HOLLMANN and TOUSTER (10) and by HICKMAN Abbreviations: (NADP and NADPH) Nicotinamide adenine dinucleotide phosphate and its reduced form. (NAD and NADH) nicotinamide adenine dinucleotide and its reduced form.

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Pentose metabolism in candida albicans. I. The reduction of D-xylose and L-arabinose

Cited by 46 publications

References 4 publications

Charge partitioning and anomalous hole doping in Rh-doped Sr2IrO4

Charge partitioning and anomalous hole doping in Rh-doped Sr2IrO4

Polyol Metabolism in the Basidiomycete Schizophyllum commune

Polyol Dehydrogenases in Candida Albicans

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