Pentatrichomonas hominis and other intestinal parasites in school-aged children: coproscopic survey

Abdo, Sarah; Ghallab, Marwa Mohamed Ibrahim; Elhawary, Nagwa M.; Elhadad, Heba

doi:10.1007/s12639-022-01506-1

Cited by 8 publications

(4 citation statements)

References 23 publications

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“…This study found that the most prevalent protozoan was Trichomonas hominis (4%). The results of this study confirm those reported by Abdo et al 18 in school-aged children in Egypt with a prevalence of 13.8% (25 out of 180 children)…”

Section: Discussionsupporting

confidence: 92%

Prevalence of Gastrointestinal Protozoans Infections Amongst Patients Attending the Bamenda Regional Hospital

Cédric¹,

Christelle²,

Paul³

et al. 2023

Asian J. of Epidemiology

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Background and Objective: Gastrointestinal protozoans are among the high prevalent parasitic diseases causing a high significant socioeconomic impact on the health status of most developing countries. The study aimed to determine the prevalence of gastrointestinal protozoan infections in patients attending the Bamenda Regional Hospital. Materials and Methods: This study was hospital-based and carried out at the Bamenda Regional Hospital located in the Bamenda II subdivision. A well-structured questionnaire was administered to patients to collect demographic data (age, sex) and to determine their level of knowledge on gastrointestinal parasitic infections. A total of 100 stool specimens were collected from both male and female patients attending the Bamenda Regional Hospital. The collected stool samples were analysed using the direct wet mount method. Results: The overall prevalence in this study was 10% with 4% of patients infected with Trichomonas hominis and the rest had 2% infection each with Entamoeba histolytica, Entamoeba coli and Iodamoeba butschlii. There was no statistically significant difference (p>0.05) between the prevalence of men (10.42%) and women (9.62%). The prevalence among workers in the informal system (15.38%) was higher than among students (9.89%) and those in the formal system (0%). However, there was no statistically significant difference (p = 0.675). Illiterates (27.27%) and primary school subjects (27.58%) were more infected. Conclusion: Current study revealed an association between gastrointestinal parasitic infections and potential risk factors in participants. Non-compliance with hygienic rules exposes these participants to parasitic infection. However, it will be important to extend the study to other hospitals in the country.

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Section: Discussionsupporting

confidence: 92%

Prevalence of Gastrointestinal Protozoans Infections Amongst Patients Attending the Bamenda Regional Hospital

Cédric¹,

Christelle²,

Paul³

et al. 2023

Asian J. of Epidemiology

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“…It can be transmitted via the fecal-oral route, it is potentially zoonotic [20] and some studies suggest that it can cause disease symptoms such as diarrhea and gastrointestinal or pulmonary diseases in children and older people but its pathological role is still unclear [5,263]. This protozoan was detected in 13.8% of schoolchildren examined in Egypt [263,264].…”

Section: Pentatrichomonas Hominismentioning

confidence: 99%

Protozoan Infections Acquired from Food or Drinking Water: An Update

Rossi,

Amadoro,

Santonicola

et al. 2024

Preprint

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This review summarizes the most recent developments of research on protozoan parasite infections ac-quired through food and drinking water and is aimed at gathering updated knowledge on the risk factors, illnesses caused, and measures for prevention. Reports included dated from 2019 to the present and regarded recent outbreaks and cases of severe infec-tions, prevalence in different population segments and food handlers, and occurrence in food and drinking water. Cryptosporidium spp., Entamoeba histolytica, Giardia intestinalis, Trypanosoma cruzi and Toxoplasma gondii were the microorganisms most frequently involved in large outbreaks and/or severe infections, while Cyclospora cayetanensis was most frequently involved in single case reports. Cystoisospora belli was implied in severe infections in immunocompromised patients, while Blastocystis homi-nis, Sarcocystis spp., Dientamoeba fragilis, Endolimax nana and Pentatrichomonas hominis appeared to be less relevant for number of symptomatic infections and pathogenic potential. A progressive improvement in surveillance of protozoan infections and infection sources was highlighted, especially in developed countries. The apparent increase in cases was concomitant with the implementa-tion of reporting systems and the application of molecular diagnostic methods that represent valuable in-struments for establishing epidemiological links and preventing or limiting outbreaks. The pathogenic role and sources of infection should be better elucidated for some species.

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“…Pentatrichomonas hominis is an anaerobic flagellated protozoan that primarily colonizes the large intestines of mammals and is primarily transmitted through the fecal-oral route [ 20 ]. Initially considered a commensal protozoan, P. hominis has been found to induce gastrointestinal symptoms, including diarrhea, in humans [ 1 ], dogs [ 24 ], and cats [ 3 ]. It has also been linked to systemic lupus erythematosus [ 23 ], irritable bowel syndrome [ 30 ], and rheumatoid arthritis [ 6 ] in humans.…”

Section: Introductionmentioning

confidence: 99%

Unraveling the pathogenic potential of the Pentatrichomonas hominis PHGD strain: impact on IPEC-J2 cell growth, adhesion, and gene expression

Zhu,

Cai,

Fang

et al. 2024

Parasite

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Pentatrichomonas hominis, a flagellated parasitic protozoan, predominantly infects the mammalian digestive tract, often causing symptoms such as abdominal pain and diarrhea. However, studies investigating its pathogenicity are limited, and the mechanisms underlying P. hominis-induced diarrhea remain unclear. Establishing an in vitro cell model for P. hominis infection is imperative. This study investigated the interaction between P. hominis and IPEC-J2 cells and its impact on parasite growth, adhesion, morphology, and cell viability. Co-cultivation of P. hominis with IPEC-J2 cells resulted in exponential growth of the parasite, with peak densities reaching approximately 4.8 × 105 cells/mL and 1.2 × 106 cells/mL at 48 h for initial inoculation concentrations of 104 cells/mL and 105 cells/mL, respectively. The adhesion rate of P. hominis to IPEC-J2 cells reached a maximum of 93.82% and 86.57% at 24 h for initial inoculation concentrations of 104 cells/mL and 105 cells/mL, respectively. Morphological changes in IPEC-J2 cells co-cultivated with P. hominis were observed, manifesting as elongated and irregular shapes. The viability of IPEC-J2 cells exhibited a decreasing trend with increasing P. hominis concentration and co-cultivation time. Additionally, the mRNA expression levels of IL-6, IL-8, and TNF-α were upregulated, whereas those of CAT and CuZn-SOD were downregulated. These findings provide quantitative evidence that P. hominis can promote its growth by adhering to IPEC-J2 cells, inducing morphological changes, reducing cell viability, and triggering inflammatory responses. Further in vivo studies are warranted to confirm these results and enhance our understanding of P. hominis infection.

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Pentatrichomonas hominis and other intestinal parasites in school-aged children: coproscopic survey

Cited by 8 publications

References 23 publications

Prevalence of Gastrointestinal Protozoans Infections Amongst Patients Attending the Bamenda Regional Hospital

Prevalence of Gastrointestinal Protozoans Infections Amongst Patients Attending the Bamenda Regional Hospital

Protozoan Infections Acquired from Food or Drinking Water: An Update

Unraveling the pathogenic potential of the Pentatrichomonas hominis PHGD strain: impact on IPEC-J2 cell growth, adhesion, and gene expression

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