Pentafluorobenzaldehyde and its utilizing in organic synthesis

Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes

“…Addition at the 4-position is in line with the usual orientation of addition observed for perfluorinated arenes [20]. Treatment of the benzaldehydes with either methyl α-mercaptoacetate 3a or 2'-mercaptoacetophenone 3b in the presence of triethylamine as base led to the clean conversion to the 6-substituted-4,5,7-trifluorobenzothiophenes 5aa-5be in moderate to excellent yields.…”

A faux hawk fullerene with PCBM-like properties

“…There is general agreement that, all other things being equal, aromatic C–F bonds undergo S N Ar substitution much faster than aromatic C–Cl, C–Br, or C–I bonds. 61 – 65 However, there is still controversy about whether a true Meisenheimer 69 intermediate is formed (even if it cannot be detected spectroscopically) 70 – 76 or whether the reaction involves a single Meisenheimer-like transition state. 77 – 80 …”

Pyrrolidine-functionalized fluorine-containing graphene sheets

“…11 This functionalized graphite was then subjected to bath sonication in various solvents to exfoliate functionalized graphene sheets. [20][21][22][23][24] Furthermore, because XPS measurement is sensitive to F atoms, the anchored pentafluorophenyl groups make it easier to identify and quantify the functionalities, 32 and more importantly, the inclined nucleophilic substitution of para-fluorine of pentafluorophenyl by sulphur, oxygen and nitrogen nucleophiles 33 makes it possible to attach other functional groups on the edge of graphene sheets. 28,29 So the insertion of solvent molecules into graphite layers will be facilitated by these attached pentafluorophenyl ''wedges'' when sonicating in the solvent, and as a result, the exfoliation of the functionalized graphite might be easier than that of pristine graphite.…”