Pentaerythritol crystallization – Influence of the process conditions on the granulometric properties of crystals

Relationship between Surface Properties and In Vitro Drug Release from a Compressed Matrix Containing an Amphiphilic Polymer Material

“…On the other hand, the compressibility percentage (Carr´s index) for ampicillin trihydrate was 7%, while the PAM-18K polymer one was 15%, indicating good compressibility properties. Regarding the value of repose angle for the trihydrate ampicillin it was found to be 44°, while for the PAM-18K polymer it was 36°, indicating a poor flow for both materials, which is consistent with the presented morphology of the study materials [ 8 ].…”

“…The last decades have been characterized by several advances in the chemistry and pharmacy fields, among which the development of new systems for controlled drug delivery represents an area of great interest [ 1 , 2 , 3 , 4 ]. These modified release methods depend on multiple factors, such as the shape and size of the tablets [ 5 ], the manufacturing process [ 6 ], the granulometric properties [ 7 , 8 , 9 ] and the physicochemical characteristics of the other compounds in the compressed blends, wherein polymer-based excipients are remarkable for their physicochemical properties and the diversity of their multiple applications [ 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. Different kinds of natural, hemisynthetic and synthetic polymers have been used for this purpose, among which the copolymers derived from maleic anhydride have shown great potential as controlled drug release systems [ 10 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Solubility Measurement and Data Correlation of Pentaerythritol in Four Binary Solvent Systems at Temperatures from 283.15 to 323.15 K

“…To confirm the accuracy of our measurement, we compared our solubility data of PE in water with those reported by other researchers, ,,, as shown in Figure . Apparently, in the studied range of temperatures, the deviation between our experimental results and those in the literature is relatively small and the subtle distinction might be caused by the differences in the experimental method and the operation.…”

“…115-77-5, Figure ), as an important neo-structure polyhydric alcohol, is primarily prepared by the reaction of acetaldehyde with formaldehyde in an alkaline medium. PE is widely used in alkyd resins, radiation cure monomers, poly­(vinyl chloride) (PVC) stabilizers, polyurethanes, rosin esters, synthetic lubricants, pigment treatment, antioxidants, and explosives. − It is also used in manufacture as drying oils for paints and varnishes, which cannot discolor under UV light …”

“…The solubility of APIs is the basis of solvent selection and design for the crystallization process, which plays an important role in the purity, crystal habit, and particle size of the product. − Moreover, solubility is the key factor that affects the pharmacological bioavailability and the therapeutic effects in the human body . According to the previous studies, the solubility of PE in water has been studied by some researchers. ,,, Yet, to the best of our knowledge, no solubility data of PE in binary solvents have been reported in the literature. Therefore, in this work, the solubilities of PE in four binary solvents, including methanol + water, ethanol + water, isopropanol + water, and acetonitrile + water, were measured by the gravimetric method at temperatures ranging from 283.15 to 323.15 K at 0.1 MPa.…”