Penta-O-galloyl-beta-D-glucose enhances antitumor activity of imatinib and suppresses the growth of K562 cells in mice

Kwon, Tae‐Rin

doi:10.5897/ajpp12.1058

Cited by 4 publications

(2 citation statements)

References 16 publications

(16 reference statements)

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“…1) are gallotannins that are found in a number of to exhibit in vivo anti-cancer activities against prostate cancer [14,15], lung cancer [16] and sarcoma [17]. Kwon et al [18] demonstrated that PGG strongly suppressed K562 xenograft growth in female athymic nude mice after intraperitoneal (i.p.) injection of 4 or 10 mg/kg every 2 days for 18 days.…”

Section: Introductionmentioning

confidence: 98%

A validated liquid chromatography–tandem mass spectrometry method for the determination of methyl gallate and pentagalloyl glucopyranose: Application to pharmacokinetic studies

Jiamboonsri

Pithayanukul

Bavovada

et al. 2015

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 98%

A validated liquid chromatography–tandem mass spectrometry method for the determination of methyl gallate and pentagalloyl glucopyranose: Application to pharmacokinetic studies

Jiamboonsri

Pithayanukul

Bavovada

et al. 2015

Journal of Chromatography B

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“…Tae-Rin Kwon et al attempted to treat chronic myelogenous leukemia with a combination of PGG and imatinib [ 136 ]. They found that PGG synergistically enhanced the antitumor activity of imatinib in myelogenous leukemia cells.…”

Section: Synergistic Effect Of Pgg On Cancer Chemotherapy and Radioth...mentioning

confidence: 99%

Pentagalloyl Glucose: A Review of Anticancer Properties, Molecular Targets, Mechanisms of Action, Pharmacokinetics, and Safety Profile

Wen

Dechsupa

et al. 2023

Molecules

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Pentagalloyl glucose (PGG) is a natural hydrolyzable gallotannin abundant in various plants and herbs. It has a broad range of biological activities, specifically anticancer activities, and numerous molecular targets. Despite multiple studies available on the pharmacological action of PGG, the molecular mechanisms underlying the anticancer effects of PGG are unclear. Here, we have critically reviewed the natural sources of PGG, its anticancer properties, and underlying mechanisms of action. We found that multiple natural sources of PGG are available, and the existing production technology is sufficient to produce large quantities of the required product. Three plants (or their parts) with maximum PGG content were Rhus chinensis Mill, Bouea macrophylla seed, and Mangifera indica kernel. PGG acts on multiple molecular targets and signaling pathways associated with the hallmarks of cancer to inhibit growth, angiogenesis, and metastasis of several cancers. Moreover, PGG can enhance the efficacy of chemotherapy and radiotherapy by modulating various cancer-associated pathways. Therefore, PGG can be used for treating different human cancers; nevertheless, the data on the pharmacokinetics and safety profile of PGG are limited, and further studies are essential to define the clinical use of PGG in cancer therapies.

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Galloylation of polyphenols alters their biological activity

Karaś

Ulrichová

Valentová

2017

Food and Chemical Toxicology

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Penta-O-galloyl-beta-D-glucose enhances antitumor activity of imatinib and suppresses the growth of K562 cells in mice

Cited by 4 publications

References 16 publications

A validated liquid chromatography–tandem mass spectrometry method for the determination of methyl gallate and pentagalloyl glucopyranose: Application to pharmacokinetic studies

A validated liquid chromatography–tandem mass spectrometry method for the determination of methyl gallate and pentagalloyl glucopyranose: Application to pharmacokinetic studies

Pentagalloyl Glucose: A Review of Anticancer Properties, Molecular Targets, Mechanisms of Action, Pharmacokinetics, and Safety Profile

Galloylation of polyphenols alters their biological activity

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