Penile verrucous carcinoma

Demonstration of Human Papillomavirus Type 2 in a Verrucous Carcinoma of the Foot

“…As such. HPV types 6-11 principally, but also 1,2,3 and 4 are asso ciated w'ith verrucous carcinoma of mucosa and skin [11][12][13][14][15][16][17][18]. In a recent report.…”

Verrucous Carcinoma of the Penis: Importance of Human Papillomavirus Typing for Diagnosis and Therapeutic Decision

“…This carcinoma is extremely well differentiated and characterized by a local aggressivity with little metastatic potential [8,10,14]. This tumor has been described in nearly all parts of the body, but particu larly on the penis, where it has received many synonymous designa tions, such as 'giant condyloma' or 'Buschke-Löwenstein tumor' [15,16],Itaccounts for only 5-15%ofall penile cancers [8,10,17]. Clas-…”

“…The differential diagnosis is capital since the prognoses of these two tumors are totally different [3,7,13], We point out, in particular, that the verrucous carcinoma, contrary to the classical epidermoid carci noma, only rarely produces métastasés. In addition to this observa tion, it is noteworthy that those cases with métastasés had received radiation therapy, which is absolutely contraindicated for the verru cous carcinoma [10,15,17], In recent years, advances in techniques of molecular biology have allowed to suggest the role of various HPV…”

“…The presence of human papillomavirus (HPV) DNA was studied by using in situ molecular hybridization on deparaffinized tissue sec tions under stringent conditions (melting temperature below 190 C) with biotinylated plasmid DNA probes for HPV types 1, 6, 11, 16, 18, 31, 33 and 35 according to the procedure described by Brigati et al [5], The biotinylated probes were prepared at a concentration of 200 ng/ml in hybridization buffer containing 2 X SSC, 5 % dextran Verrucous Carcinoma of the Penis N oel/V andenbossche/Peny/Sassine/ de Dobbeleer/Schulman/Verhest as causative agents for the development of verrucous carcinoma and particularly in the penis the types 6 and 11 [4,17], This confirms the hypothesis that this tumor derives from condyloma acuminatum in which HPV 6 and 11 are found in 95% of cases [9,18]. This is in contrast to HPV 16 and 18, which are mostly associated to the classic epidermoid carcinomas [2,11,12].…”

Invasive Penile Carcinoma: A Review

“…Histopathologic examination may reveal either a benign epidermoid outgrowth or various epithelial disorders, including warts, keratoacanthoma, intraepithelial carcinoma, SCC, or VC. 3,14,15 Penile LS is a chronic inflammatory disorder of unknown cause, usually appearing as white, atrophic, and coalescing plaques on the glans and foreskin leading to urethral stenosis and/or phimosis (balanitis xerotica obliterans) that should be regarded as a significant risk factor for the development of penile carcinoma, as malignant changes have been observed in 9.3% of cases in some series. [16][17][18] Clinically, malignant transformation is usually revealed by the presence of nodules or ulcerated plaques 19 (Figure 2).…”