Penile Cancer: Relation of Extent of Nodal Metastasis to Survival

Abstract

A retrospective review of 199 patients with penile cancer revealed that the extent of inguinal nodal metastasis was related to survival after radical ilioinguinal dissection. Patients with unilateral inguinal nodal involvement had a 56 per cent median 5-year survival rate, whereas those with bilateral inguinal nodal metastasis, extranodal tumor extension or iliac nodal involvement had a 9 per cent median 5-year survival rate.

Irradiation of regionally advanced carcinoma of the penis

“…In others, the enlargement was observed later on; in 4 patients (patients 1, 2, 10, and 11), the nodes were enlarged due to post-penectomy recurrence and surveillance policy, in one (patient 5), the enlargement was observed after prophylactic lymphadenectomy, and in one (patient 3), after sentinel lymph node dissection. In 8 patients (Table 1), radiotherapy was indicated because of palpable inguinal tumours which were diagnosed either as inoperable infiltrations in the nodes in 5 patients (patients [8][9][10][11][12] or as inoperable post-lymphadenectomy locoregional recurrence in 3 (patients 5-7). Microscopic tumour residue detected after lymphadenectomy in 4 patients was also an indication to apply radiotherapy.…”

Surgical Management of Squamous Cell Carcinoma of the Penis

“…5,6,13,14 Unreliable patients or others who cannot be followed adequately are best served by prompt inguinal lymphadenectomy. Considerable debate has ensued over the years regarding immediate or delayed lymphadenectomy in other patients with clinically negative groins.…”

“…Metastasis to the pelvic nodes in the absence of inguinal node metastases is an extremely rare event and has not been observed in many modern series. 5,14,23 In the setting of negative superficial and deep inguinal lymphadenectomies and a negative pelvic CT scan, pelvic lymphadenectomy is not required.…”

Human papillomavirus as a prognostic factor in carcinoma of the penis

“…After amplification with these generic primers of HPV, the PCR products were submitted to dot blot hybridization. 19 Briefly, the PCR products and controls (plasmid clones harboring various HPV DNAs kindly provided by E.M. deVilliers, DKFZ, Germany and G. Orth, Institute Pasteur, Paris) were denatured with 1.6 N NaOH and 0.1 M ethylenediamine tetraacetic acid, pipetted into nylon membranes under vacuum, and hybridized to ATP 32 -P labeled type specific oligonucleotides independently or in cocktails, including HPV types 6,11,16,18,31,33,34,35,39,40,42,43,44,45, 51, 52, 54, 56, and 58 in cocktails. 19 After hybridization and washing, filters were exposed to X-ray films for 18 -36 hours at Ϫ70°C, with intensifying screens.…”