Penggunaan Skor Pediatric Logistic Organ Dysfunction Harian sebagai Prediktor Mortalitas Anak yang Dirawat di Unit Perawatan Intensif Anak

Salim, Hendra; Suparyatha, Ida Bagus Gede; Nym, Budi-Hartawan I

doi:10.14238/sp16.2.2014.141-6

Cited by 2 publications

(2 citation statements)

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“…They also noted that low PELOD score occured on day 23, moderate score on day 12, and high score on day 7. 9 The difference in our study was that we only evaluated PELOD-2 score on the first day of the treatment, not daily, and .the previous study used PELOD as predictors, but from our study we used PELOD-2 score which modified from PELOD score. A limitation of our study was that serum T3 level was measured only at the beginning of treatment, not when the patient experienced the outcome.…”

Section: Resultsmentioning

confidence: 98%

Triiodothyronin (T3) as a parameter of mortality in sepsis patients in the PICU

Djoko¹,

Hartawan²,

Arhana³

et al. 2019

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Background Thyroid hormone stimulates the regulation of β-adrenergic receptors in order to increase the inotropic effect of the heart myocardium. Euthyroid sick syndrome is a disorder of non-metabolic thyroid function, which is characterized by a decrease in triiodothyronine (T3) levels in patients with non-thyroid systemic disease, such as sepsis. Low serum T3 hormone level is a potentially high-risk factor for mortality from sepsis. Objective To assess for a relationship between decreased serum T3 levels and mortality in pediatric sepsis patients admitted in the PICU. Methods This study used a nested case-control design. The subjects were children aged 1 month-18 years who were diagnosed with sepsis in the pediatric intensive care unit at Sanglah Hospital, Denpasar, Bali, from September 2017 to January 2019. Results A total of 90 children were included, of whom 44 died and 46 survived. Median age was 10.5 (IQR 44) months in subjects who died and 9 (IQR 50) months in those who survived. The majority of subjects in both groups had well-nourished nutritional status. Bivariate analysis revealed that significantly more subjects who died had low serum T3 (≤1 ng/dL), PELOD-2 score ≥5, than subjects who survived. Multivariate analysis revealed that serum T3 £1 ng/dL (OR 55.1; 95%CI 9 to 334.8; P<0.001) and PELOD-2 score ³5 (OR 6.5; 95%CI 1.6 to 26.7; P=0.01) were significant risk factors for sepsis mortality. Conclusion Low serum T3 level and high PELOD-2 score are risk factors for death in sepsis.

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Section: Resultsmentioning

confidence: 98%

Triiodothyronin (T3) as a parameter of mortality in sepsis patients in the PICU

Djoko¹,

Hartawan²,

Arhana³

et al. 2019

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“…(4) A research at PICU of Haji Adam Malik General Hospital, Medan, showed the presentation of sepsis in boys was higher than girls with the most age was 1-50 months (76.5%) and the mortality rate was 42%. (5) The new definition of sepsis was issued by The Society of Critical Care Medicine and The European Society of Intensive Care Medicine as life-threatening organ dysfunction. (6) Pathophysiological sepsis is a complex process between pathogens and the body's antibody system.…”

Section: Introductionmentioning

confidence: 99%

The Usefulness of C-Reactive Protein, Procalcitonin, and PELOD-2 Score as a Predictive Factor of Mortality in Sepsis

Lubis

Nasution

2020

Indones Biomed J

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BACKGROUND: Sepsis in children is a significant cause of morbidity and mortality in the pediatric intensive care unit (PICU). Assessment of pediatric sepsis using serial Pediatric Logistic Organ Dysfunction (PELOD)-2 score can be used as a prognostic factor. The use of biomarkers of sepsis is also used for diagnosis and predicting outcomes. Many studies have suggested that C-reactive protein (CRP) and procalcitonin (PCT) can be used to predict mortality.METHODS: A prospective cohort study was conducted to evaluate CRP, PCT, PELOD-2 score and its combination as a predictive factor of mortality in sepsis. All patients admitted to PICU Haji Adam Malik General Hospital, Medan, from April to November 2019 with suspected sepsis were included in this study. Blood examination and PELOD-2 scores were examined in the first 24 hours.RESULTS: A total of 79 children were included with a mortality rate 55.7%. The CRP, PCT, and PELOD-2 score were higher in nonsurvivor (2.8 (0.5-22.4) mg/dL; 9.36 (0.13-79.8) ng/mL; 9 (3-21), respectively). In multivariate logistic regression analysis, neither CRP nor PCT values could be independent predictors of mortality. The PELOD-2 score can be an independent predictor for mortality at a cut-off score of 7 (OR: 3.47 (95% CI: 1.68-7.19)). The combination of PELOD-2 and CRP scores as predictors of mortality showed lower values than PELOD-2 and PCT scores (0.80 vs. 0.95). The combination of all parameters only adds 1% of the predicted mortality value.CONCLUSION: PELOD-2 score with PCT value are recommended to predict mortality children with sepsis.KEYWORDS: sepsis, mortality, C-reactive protein, procalcitonin, PELOD-2 score

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Penggunaan Skor Pediatric Logistic Organ Dysfunction Harian sebagai Prediktor Mortalitas Anak yang Dirawat di Unit Perawatan Intensif Anak

Cited by 2 publications

References 5 publications

Triiodothyronin (T3) as a parameter of mortality in sepsis patients in the PICU

Triiodothyronin (T3) as a parameter of mortality in sepsis patients in the PICU

The Usefulness of C-Reactive Protein, Procalcitonin, and PELOD-2 Score as a Predictive Factor of Mortality in Sepsis

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