The Usefulness of C-Reactive Protein, Procalcitonin, and PELOD-2 Score as a Predictive Factor of Mortality in Sepsis

Lubis, Munar; Lubis, Aridamuriany Dwiputri; Nasution, Badai Buana

doi:10.18585/inabj.v12i2.1073

Cited by 4 publications

(3 citation statements)

References 16 publications

(19 reference statements)

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“…Procalcitonin levels decrease rapidly after inflammation is resolved. (11,34,35) The lowest procalcitonin levels in this study were 0.12 ng/mL and the levels highest were 9.11 ng/mL.…”

Section: Discussionmentioning

confidence: 52%

Presepsin Levels and Neutrophil-to-Lymphocyte Ratio are Positively Correlated with Procalcitonin Levels in Early Onset Neonatal Sepsis

et al. 2023

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BACKGROUND: Early-onset neonatal sepsis (EONS) is an acute infection and sepsis occurring within the first 24 hours of new-born life. An increase in procalcitonin levels, presepsin levels, and neutrophil-to-lymphocyte ratio (NLR) in EONS subjects have been reported. However, whether presepsin levels and NLR affect the procalcitonin levels in EONS patients who have received antibiotic therapy has not been certainly known. This study was conducted to determine the correlation between presepsin levels and NLR with procalcitonin levels in EONS subjects.METHODS: A cross-sectional study involving 52 EONS subjects were conducted, and blood samples from subjects were collected. Presepsin levels were examined by enzyme-linked immunosorbent assay (ELISA) method, NLR was calculated from the absolute number of neutrophils divided by the absolute number of lymphocytes, and procalcitonin levels were examined by chemiluminescent microparticle immunoassay (CMIA) method. RESULTS: Median of procalcitonin levels and presepsin levels were 0.435 (0.12-9.11) ng/mL and 108.33 (71.43-1287.76) ng/L, respectively. While NLR value was 1.68 (0.2-7.52). There was significant difference between procalcitonin and presepsin levels (p=0.000), and so does between procalcitonin levels and NLR (p=0.001). Based on the multivariate analysis, presepsin levels also affected the procalcitonin levels (p=0.000; 95% CI: 0.001-0.004).CONCLUSION: The results of the study showed that there was significant correlation between presepsin levels and NLR with procalcitonin levels in EONS patients, suggesting that presepsin levels, NLR, and procalcitonin levels are potential candidates for EONS biomarkers.KEYWORDS: EONS, NLR, presepsin, procalcitonin

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“…Procalcitonin levels decrease rapidly after inflammation is resolved. (11,34,35) The lowest procalcitonin levels in this study were 0.12 ng/mL and the levels highest were 9.11 ng/mL.…”

Section: Discussionmentioning

confidence: 52%

Presepsin Levels and Neutrophil-to-Lymphocyte Ratio are Positively Correlated with Procalcitonin Levels in Early Onset Neonatal Sepsis

et al. 2023

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“…PELOD 2 score as the best predictor of mortality compared to other predictors when used repeatedly. (Niederwanger, 2018) In this study, the PELOD 2 score was obtained using a cut off value of 7, the p value = ) could be a predictor of mortality for patients admitted to the pediatric intensive room (Lubis et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

Comparison of Prism Iv and Pelod 2 Score as Predictor of Mortality in Critically Ill Children in Adam Malik General Hospital

Silaban¹,

Lubis²,

Lubis³

2021

IJRP

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Background: Critical illness is collection of conditions and disorders that have impact on the occurrence of organ dysfunction, prolonged morbidity and mortality. Score of mortality objectively calculates the severity of disease and predicts risk of mortality according to the clinical condition of patient. Today, no standardized scoring system that used in PICU for initial assessment of patients in Indonesia yet. Objective: Comparing mortality's predictor ability between PRISM IV and PELOD 2 score as predictors of mortality in critically ill children at Haji Adam Malik General Hospital Medan. Subject and Methods: Prospective cohort study was conducted in PICU of Haji Adam Malik General Hospital from September 2020 to March 2021. Characteristics of the sample were obtained through the medical record of patients treated in PICU. Assessment of PRISM IV and PELOD 2 score was carried out on the first and third days of patient being admitted in PICU. Results: Of the 35 children who were treated, 15 (42.9%) children were treated with respiratory problems. There were 18 (51.4%) children died. It was found that there was no significant difference mean score of PRISM IV and PELOD 2 score on first and third days of examination (p>0.05). It was also found that PRISM IV could predict mortality of children with critical illness on the first and third days (AUC 49.7%; 57.2%). PELOD 2 could predict mortality on first and third days (AUC 65.4%; 69.3%). Conclusion: PRISM IV on the first and third days has lower accuracy than PELOD 2 in predicting mortality in critically ill children at Haji Adam Malik General Hospital Medan. Keywords: critically ill children;PRISM IV;PELOD 2 the intensive care room (first 24 hours) and then evaluated every 24 hours until the patient leaves the intensive care room. PRISM IV is the latest scoring that adds several variables, namely age, source of admission, cardiopulmonary arrest within 24 hours before admission, cancer, low risk system of primary dysfunction which includes dysfunction in the endocrine, hematologic, musculoskeletal and renal systems that are affected. The result summed with the scores that have been obtained from the neurologic and non-neurological subcategories in the PRISM III scoring. (Pollack et al, 2016) The Pediatric Logistic Organ Dysfunction score is a descriptive scoring system used to determine the presence of organ dysfunction/failure, and the severity of illness in critically ill children. The PELOD 2 score is a revision and validation of the previous PELOD score. The PELOD score assessment includes the neurological, cardiovascular, renal, respiratory and hematologic systems. (Iskandar, 2008).

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“…Other studies done previously by Horvat et.al and Lubis et.al was 21.7% and 55.7% respectively. [21][22][23] From this study, the respiratory disease was the most common disease for patients admitted to PICU and was the most common cause of death. Based on this data, it is necessary to focus on medical facilities and interventions such as immunization, improving nutrition, education about the dangers of disease and anaemia therapy for strategies to reduce respiratory-related mortality, and children under one year of age with respiratory diseases to receive…”

Section: Discussionmentioning

confidence: 98%

Case distribution and survival rate in Pediatric Intensive Care Unit (PICU) at Banjarmasin, Indonesia

Anam¹,

Putri²,

Ramadhani³

et al. 2022

PEDSCIJ

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Introduction: Epidemiological studies about case distribution and survival in PICU is important to do. Knowledge of these epidemiological studies can assist in decision-making to improve patient quality of care. So far there is no data about the case distribution and survival rate of the patients in the PICU in Banjarmasin, Indonesia. This study aims to provide an overview of case distribution and survival rates of patients treated at the PICU of Ulin Hospital Banjarmasin. Methods: A retrospective study was conducted at the PICU of Ulin Hospital Banjarmasin. Data was taken from patients’ records from January 2017 to December 2018. Results: A total of 202 patients were admitted to the PICU, males 109 and females 93. The mortality rate was 17% with a survival rate, 83% with a mean length of stay of 10 days. The most common patient diagnosis was pneumonia 23%, meningoencephalitis 10%, and dengue shock syndrome 6%. The system commonly involved was respiratory system 26%, central nervous system 17%, and infection 13%. The median length of stay for overall admission was 9 days with a mean of 10 days. The cardiovascular and respiratory systems tend to have lower survival rates, 78%, and 79% respectively. Conclusions: This study shows that respiratory, neurological, and infectious diseases are the most common diseases that cause children to be admitted to the PICU. The mortality rate in this study was 17% with a mean length of stay of 10 days. It is necessary to focus on medical facilities and interventions to reduce respiratory-related mortality.

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The Usefulness of C-Reactive Protein, Procalcitonin, and PELOD-2 Score as a Predictive Factor of Mortality in Sepsis

Cited by 4 publications

References 16 publications

Presepsin Levels and Neutrophil-to-Lymphocyte Ratio are Positively Correlated with Procalcitonin Levels in Early Onset Neonatal Sepsis

Presepsin Levels and Neutrophil-to-Lymphocyte Ratio are Positively Correlated with Procalcitonin Levels in Early Onset Neonatal Sepsis

Comparison of Prism Iv and Pelod 2 Score as Predictor of Mortality in Critically Ill Children in Adam Malik General Hospital

Case distribution and survival rate in Pediatric Intensive Care Unit (PICU) at Banjarmasin, Indonesia

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