Pengaruh pemberian ekstrak kedelai hitam (Glycine soja.) berbagai dosis terhadap kadar glukosa darah, kadar insulin, dan HOMA-IR

Kurniawati, Desy; Dharmana, Edi; Rachmawati, Banundari; Pemayun, Tjokorda Gde Dalem

doi:10.14710/jgi.6.1.44-50

Cited by 2 publications

(2 citation statements)

References 17 publications

(22 reference statements)

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“…The higher the HOMA-IR value, the higher the degree of insulin resistance. Insulin resistance is measured using the HOMA-IR index based on fasting blood sugar levels and insulin levels, normal values for HOMA-IR < 4.0 and > 4.0 mean insulin resistance occurs (Kurniawati et al, 2017). The HOMA-β value has a significant effect in increasing the HOMA-β value, but it is known that there is no significant difference in both interventions for 7 days and 15 days.…”

Section: Effect Of Patikan Kebo Leaf Extract On Biomarker Sensitivity...mentioning

confidence: 99%

Antihyperglycemic effect of patikan kebo in the rat models of diabetic

Widyaningrum

Wasita

Nuhriawangsa

2023

jika

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Diabetes mellitus is a heterogeneous metabolic disorder characterized by an increase in blood sugar levels due to insulin disorders. Current treatment for diabetes mellitus focuses on controlling and lowering blood glucose. However, long-term treatment for diabetes mellitus can have side effects that cause several medical problems. Medical therapy using natural ingredients as an alternative therapy is currently being considered because of its potential and minimal side effects. Patikan kebo is a natural ingredient containing the flavonoid quercetin group. However, the antihyperglycemic effect of the patikan kebo leaves is not known with certainty. This study aimed to determine the effect of patikan kebo leaf extract (EDPK) on the levels of GDP, insulin, HOMA-IR, and HOMA-β in male rats with diabetes mellitus induced by streptozotocin (STZ) and nicotinamide (NA). The design of this study was a pre-and post-test control group design. 42 male Wistar rats were divided into 7 groups: K (normal mice), KN (DMT2 mice without intervention), KP (DMT2 mice intervened with acarbose 1.8 mg/kg BW/day), P1 (DMT2 mice intervened with EDPK dose 75 mg/kg BW/day), P2 (DMT2 mice intervened with EDPK dose 150 mg/kg BW/day), and P3 (DMT2 rats intervened with EDPK dose 300 mg/kg BW/day). The intervention was given for 7 and 15 days. The data were statistically analyzed using the Two Way ANOVA test. EDPK was proven to decrease GDP and HOMA-IR levels and increase insulin and HOMA-β in the male Wistar rat model of diabetes mellitus induced by STZ+NA. EDPK with a dose of 300 mg/kg BW/day proved to have the strongest antihyperglycemic effect.

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Section: Effect Of Patikan Kebo Leaf Extract On Biomarker Sensitivity...mentioning

confidence: 99%

Antihyperglycemic effect of patikan kebo in the rat models of diabetic

Widyaningrum

Wasita

Nuhriawangsa

2023

jika

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“…Penelitian yang dilakukan Fawwaz et al, (2017) menyatakan bahwa kedelai hitam memiliki kandungan senyawa antioksidan yang lebih tinggi dibandingkan kedelai kuning. Kandungan antioksidan dalam 100 gram kedelai hitam terdiri dari 222,49 mg antosianin dan 367,00 mg isoflavon (Dewi, 2017), sedangkan kedelai kuning memiliki kandungan sebesar 183 mg/100g (Sulistiani et al, 2010). Kulit biji kedelai memiliki senyawa antosianin yang merupakan salah satu sumber antioksidan (Choung, Myoung-Gun et al, 2001), antosianin yang tinggi berarti memiliki aktivitas antioksidan yang besar.…”

Section: Hasil Danunclassified

Karakteristik Minuman Sinbiotik Soyghurt Kedelai Kuning (Glycine max ) dan Kedelai Hitam (Glycine soja L.) dengan Penambahan Inulin pada Konsentrasi yang Berbeda

Faiz

Santosa²,

Purnawanto³

2022

PSPFS

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Minuman sinbiotik merupakan minuman yang mengandung bakteri probiotik sekaligus prebiotik sebagai substrat bakteri probiotik. Penelitian ini bertujuan untuk mengetahui jenis kedelai, konsentrasi inulin dan interaksi yang berpengaruh terhadap karakteristik proksimat dan organoleptik sinbiotik soyghurt. Penelitian dilakukan di Laboratorium Agroteknologi dasar Fakultas Pertanian dan Perikanan Universitas Muhammadiyah Purwokerto mulai bulan april hingga juni 2022. Penelitian ini menggunakan Rancangan Acak Lengkap ( RAL ) yang terdiri dari dua faktor. Faktor pertama jenis kedelai: Kedelai kuning (Glycine max) tidak dikupas (K1), kedelai kuning (Glycine max) dikupas (K2), kedelai hitam (Glycine Soja L.) dikupas (K3) dan kedelai hitam (Glycine Soja L.) tidak dikupas K4. Faktor kedua konsentrasi Inulin: 0% (I0), 3% (I1), 5% (I2), dan 7% (I3). Variabel pengamatan pengukuran pH, kadar air, kadar protein, kadar abu, kadar karbohidrat, kadar lemak, kadar serat, uji viabilitas bakteri asam laktat, aktivitas antioksidan dan organoleptik. Hasil penelitian menunjukkan jenis kedelai hitam tidak dikupas (K4) memiliki karakteristik proksimat dan organoleptik yang paling baik dan memiliki nilai berturut-turut yaitu pH 4,48, kadar air 86,35, protein 7,03, karbohidrat 5,44, lemak 1,01, serat 9,44, antioksidan 47,71, warna 4,15 (Netral) dan keseluruhan 4,45 (Netral). konsentrasi inulin 7% memiliki karakteristik proksimat dan organoleptik yang paling baik memiliki nilai berturut-turut yaitu pH 4,32, kadar air 83,54, protein 4,58, karbohidrat 10,87, lemak 0,84, serat 8,38, BAL 23,50x108 CFU/ml dan rasa 4,36 (Netral). Interaksi K4I3 (kedelai hitam tidak dikupas) antara jenis kedelai dan konsentrasi inulin berpengaruh terhadap karakteristik proksimat dan organoleptic memiliki nilai berturut-turut yaitu pH 4,30, kadar air 84,29, protein 6,29, kadar abu 0,21, karbohidrat 8,32, lemak 0,89, serat 12,39, BAL 25x108 CFU/ml, antioksidan 50,93, warna 3,95 (Netral), aroma 4,5 (Netral), rasa 4,4 (Netral), Kelembutan 4,3 (Netral) dan keseluruhan 4,25 (Netral).

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Pengaruh pemberian ekstrak kedelai hitam (Glycine soja.) berbagai dosis terhadap kadar glukosa darah, kadar insulin, dan HOMA-IR

Abstract: Background

Cited by 2 publications

References 17 publications

Antihyperglycemic effect of patikan kebo in the rat models of diabetic

Antihyperglycemic effect of patikan kebo in the rat models of diabetic

Karakteristik Minuman Sinbiotik Soyghurt Kedelai Kuning (Glycine max ) dan Kedelai Hitam (Glycine soja L.) dengan Penambahan Inulin pada Konsentrasi yang Berbeda

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