Pengaruh Lama Waktu Maserasi Terhadap Kadar Flavonoid Dan Aktivitas Antioksidan Ekstrak Daun Kelor

Apriyati, Erni; Murdiati, Agnes; Triwitono, Priyanto

doi:10.33005/jtp.v16i1.3165

Cited by 7 publications

(9 citation statements)

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“…The determination of total flavonoid content in MoLE raw material was carried out before administering the dose of the drug to the test animal with the result of quersetin total flavonoid content of 3.71 mgQE/g (Table 1.). The result of total flavonoid content in this study is less than the study [34] of 25.36 mgQE/g with the same maceration time of 48 hours. This is due to the difference in solvent evaporation methods and the use of a freeze dryer in the study [34] is more optimal for evaporating residual solvent with the cold temperature method.…”

Section: Results and Discussion The Total Flavonoid Content Of Moring...contrasting

confidence: 79%

Combination effectiveness of glucomannan and moringa oleifera leaf extract on lipid profil of hypercholesterolemia rats

Wati,

Setyaningsih

2023

teknosains

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cholesterol levels in the blood. This study aims to determine the effectiveness of the combination of glucomannan (Amorphophallus muelleri Blume) and Moringa oleifera leaf extract on the lipid profile of hypercholesterolemic Wistar rats. This research design used True experimental with a pretest-posttest control group design. The animal used in this study was 24 male Wistar rats (Rattus norvegicus) aged 8 weeks divided into 2 control groups and 6 treatment groups of glucomannan and Moringa oleifera leaf extract. The results of this study showed that there were significant changes in TC, TG, LDL-C, and HDL-C levels (p<0.05). It can be concluded that the combination of glucomannan (Amorphophallus muelleri Blume) and Moringa oleifera leaf extract can change the lipid profile effectively in the P5 (80mg/kgBW GAmB: 120mg/kgBW MoEL) and P4 (120mg/kgBW GAmB:80mg/kgBW MoEL ) as the most influential group in reducing TG, TC, LDL-C levels and increasing HDL-C levels.

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Section: Results and Discussion The Total Flavonoid Content Of Moring...contrasting

confidence: 79%

Combination effectiveness of glucomannan and moringa oleifera leaf extract on lipid profil of hypercholesterolemia rats

Wati,

Setyaningsih

2023

teknosains

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“…49 Both extract yield values were higher than those obtained by other researchers using conventional maceration methods. 50,51 The solvent used in the extraction was 70% ethanol because of its good ability to penetrate both lipophilic and hydrophilic matrixes and cellular membranes to interact with plant metabolites. 52 The result of the emulgel formulation of Gotu kola herb and Moringa leaf extract with three formulations containing different concentrations of Carbopol and stearic acid, namely F1 (0.5%; 4%), F2 (1%; 3.5%) and F3 (1.5%; 3%) is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Formulation and Antioxidant Activity Test of Centella asiatica Herba Extract and Moringa oleifera Leaves Extract as An Anti-Aging Emulgel

2024

TJNPR

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Typically, topical formulations like creams and gels are chosen to address skin issues such as premature aging. These formulations, including creams, gels, and face masks, are commonly used by the public. Generally, these dosage forms' formulation and physical quality should conform to standards and exhibit good physical quality. However, these topical dosage forms still have their limitations. Gels struggle with delivering hydrophobic drugs, which are easily lost when exposed to sweat or water. 8 Creams require a heating process during manufacturing and can break down if the formula is incorrect, 9 while ointment (hydrocarbon-based) shows greasiness as well as phase inversion. 10 An innovative approach is needed to address the limitations of the previously mentioned topical dosage forms, such as utilizing an emulgel-a gel-based emulsion. 8 Emulgel formation utilizes a combination of hydrogel and emulsion systems to create concrete structures that enhance the stability of the bioactive ingredient or delivery method. Other advantages of emulgel are incorporating hydrophobic drugs, better loading capacity, better stability, production feasibility, low dosage form cost, and improved patient compliance. [11][12][13][14] Common excipients used in emulgel include Carbopol 940 and stearic acid. Frequently utilized as a gelling agent, Carbopol quickly disperses in water at room temperature, exhibits a wide viscosity range, and achieves the desired gel base viscosity with only a small concentration. 15,16 On the other hand, stearic acid is a versatile excipient commonly used in topical formulations and widely used in cosmetics. Stearic acid is frequently used in cream formulations when partially neutralized with alkalis or triethanolamine. This results in the generation of a creamy base when combined with 5-15 times its weight in aqueous liquid. The appearance and plasticity of the cream depend on the proportion of alkali utilized. 16 To maintain the stability of emulgel preparations, it is crucial to use the appropriate excipients at

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“…Pada penelitian ini, senyawa saponin yang terkandung dalam kulit jengkol diduga bersifat polar, sehingga dapat terekstrak menggunakan pelarut etanol yang bersifat polar. Perbedaan senyawa yang diperoleh pada suatu ekstrak dipengaruhi oleh sifat pelarut, sesuai prinsip likedissolves like, suatu pelarut akan cenderung melarutkan senyawa yang mempunyai tingkat kepolaran yang sama (Suryani et al, 2015). Hal ini sesuai dengan pendapat Buhian et al (2016), sifat polar yang dimiliki senyawa aktif akan memiliki kecenderungan terekstrak oleh pelarut polar dan sebaliknya, sifat non-polar yang dimiliki senyawa aktif akan terekstrak oleh pelarut non polar.…”

Section: Saponinunclassified

Kandungan Senyawa Bioaktif Kulit Jengkol (Archidendron Jiringa) Dengan Perbedaan Konsentrasi Pelarut Etanol Sebagai Potensi Feed Additive Ternak Ruminansia

Purnama Ningrum,

Hartati,

Suhendra

et al. 2024

JPN

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Penelitian ini bertujuan mengetahui kandungan senyawa bioaktif kulit jengkol (Archidendron Jiringa) dengan perbedaan konsentrasi pelarut etanol sebagai potensi feed additive ternak ruminansia. Materi yang digunakan dalam penelitian ini adalah tepung kulit jengkol sebanyak 50g pada setiap perlakuan. Metode penelitian yang digunakan adalah percobaan eksperimental menggunakan Rancangan Acak Lengkap (RAL) dengan 5 perlakuan dan 4 kali ulangan. Perlakuan yang digunakan adalah P1 (akuades 100%), P2 (etanol 24% (75% akuades + 25% etanol)), P3 (etanol 48% (50% akuades + 50% etanol)), P4 (etanol 72% (25% akuades + 75% etanol)), dan P5 (etanol 96% (100% etanol)). Parameter yang diamati dalam penelitian ini adalah kandungan tanin, saponin, flavonoid, dan total fenol. Data yang diperoleh dianalisis menggunakan analisis sidik ragam (ANOVA), jika hasil yang diperoleh berbeda nyata maka dilakukan uji lanjut Duncan Multiple Range Test (DMRT). Hasil penelitian ekstrak kulit jengkol menggunakan pelarut etanol dengan konsentrasi berbeda memberikan nilai kandungan tanin dan saponin yang berbeda nyata (P<0,05), sedangkan kandungan flavonoid dan total fenol tidak berbeda nyata (P>0,05). Berdasarkan penelitian yang dilakukan, dapat disimpulkan bahwa ekstrak kulit jengkol berpotensi sebagai feed additive ternak ruminansia, dibuktikan dengan hasil kandungan tanin sebesar 8,22% dan kandungan saponin 13,47% dengan konsentrasi etanol 48%, tetapi tidak memengaruhi kandungan flavonoid dan total fenol yang terekstrak dari kulit jengkol (Archidendron jiringa).

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Pengaruh Lama Waktu Maserasi Terhadap Kadar Flavonoid Dan Aktivitas Antioksidan Ekstrak Daun Kelor

Cited by 7 publications

References 0 publications

Combination effectiveness of glucomannan and moringa oleifera leaf extract on lipid profil of hypercholesterolemia rats

Combination effectiveness of glucomannan and moringa oleifera leaf extract on lipid profil of hypercholesterolemia rats

Formulation and Antioxidant Activity Test of Centella asiatica Herba Extract and Moringa oleifera Leaves Extract as An Anti-Aging Emulgel

Kandungan Senyawa Bioaktif Kulit Jengkol (Archidendron Jiringa) Dengan Perbedaan Konsentrasi Pelarut Etanol Sebagai Potensi Feed Additive Ternak Ruminansia

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