Pengaruh konsentrasi PEG 400 sebagai kosurfaktan pada formulasi nanoemulsi minyak kepayang

Abstract

Kepayang oil has a high content of linoleic and oleic acids. Linoleic and oleic acids act as emollients in the cosmetic field. Nanotechnology is one of the latestinnovations that can be used in cosmetics preparation delivery systems because it can improve the drug delivery process. This study aims to examine the effect of PEG 400 on the formulation of Kepayang oil nanoemulsion. The concentrations of tween 80 and variation concentrations of PEG 400 used in F1, F2, and F3 are 36%: 0%, 36%: 24% and 36%: 14% using the SNEDDS method. The characteristics of nanoemulsion preparations include organoleptic, particle size, polydispersity index, and zeta potential. The result of nanoemulsion production has the organoleptic form in bright yellow color and has a distinctive odor, the particle size in F1, F2 and F3 are 11.8, 13.2 and 11.3 with a polydispersity index of 0.315, 0.147 and 0.121 and zeta potential -16.2, 13.4 and 1.8. The effect of variations in surfactant concentration in the nanoemulsion formulations of kepayang oil is that the higher the level of PEG 400, it will reduce the pH and viscosity of the preparation, increase the particle size, the uniformity of droplet size uniformity, but does not affect the potential zeta value. The best formula is F2.

Formulation and Characterization of Self Nano-Emulsifying Drug Delivery System (Snedds) Fraction of N-Hexane: Ethyl Acetate From Sesewanua Leaf (Clerodendrum Fragrans Wild.)

“…Based on [27] the less variation in the concentration of PEG 400, the pH of the SNEDDS preparation will be more alkaline this is because PEG 400 is acidic. Meanwhile, according to [12,28], SNEDDS preparations with a large concentration of tween 80 will increase the pH value of the preparation because tween 80 is alkaline.…”

“…Tween 80, which is used as a surfactant in the formulation of SNEDDS preparations with a concentration that is increasing, can increase the viscosity value of the preparation; this is because the greater the concentration of tween 80 will decrease the size of the globule diameter so that it will increase the surface area and resistance of the nanoemulsion to flow and increase the viscosity value [21]. Meanwhile, based on the results of the study [27], the use of a single surfactant (tween 80) made the viscosity increase, whereas when cosurfactant was added, there was an interaction between tween 80 and PEG 400 to make the viscosity of the preparation stable. This is the same as the mixing temperature, surfactants and cosurfactants used with the results obtained in table 3, namely SFS1 1.000 cP, SFS2 1.384 cP and SFS3…”

Formulasi Nanoemulsi Mengandung Minyak Calendula (Calendula officinalis)

“…Kosurfaktan yang terpilih untuk formulasi nanoemulsi minyak calendula adalah polietilenglikol 400 dengan % transmitan sebesar 95,509 ± 0,295%. Polietilenglikol 400 merupakan mid chain hydrocarbon atau bertempat di celah-celah sistem nanoemulsi dengan pembentukan hidrogen, sehingga dapat menurunkan tegangan permukaan pada saat proses emulsifikasi sediaan nanoemulsi [7].…”

Formulation And Characterization Of Buccal Film Nanoemulsion Apigenin As Antidiabetic

“…The zeta potential test showed the physical stability of the nanoemulsion containing dispersed globules through repulsion between particles of the same charge when they are close together 36 . Based on the measurement results, the zeta potential value of apigenin nanoemulsion for the 10 formulas listed in table 3 is in the range (-17.7) mV -(-5.53) mV (close to 0), where the zeta potential value is greater (+20 mV) or less than (-20 mV) will be sterically stable by the presence of non-ionic surfactant polymer chains in micelles 14 .…”