Abstract:Apigenin (4`,5,7-trihydroxyflavone) is a flavonoid of subclass flavones that have antidiabetic therapeutic activity but limitations BCS Class II low solubility of 2.16 μg/L. To overcome these limitations, the development of nanoemulsion formulation technology, increasing solubility increases dissolution, absorption and bioavailability. It is incorporated into the buccal film for easy application and direct access to the systemic circulation. This study aims to obtain apigenin nanoemulsion with the best charact… Show more
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