Pengaruh jamur tiram putih (pleurotus ostreatus) terhadap kadar glukosa darah, profil lipid dan kadar MDA pada tikus (rattus norvegicus) diabetes melitus

Purbowati, Purbowati; Johan, Andrew; Rmd, RA Kisdjamiatun

doi:10.14710/jgi.4.2.131-137

Cited by 4 publications

(5 citation statements)

References 6 publications

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“…Specifically, Oyster-D potentially influenced glucose metabolism by enhancing insulin sensitivity and secretion within the body. This effect occurred through the activation of vitamin D receptors present on pancreatic β-cells, as suggested by Kardina et al 21 Additionally, vitamin D possessed the ability to mitigate systemic inflammation and enhance insulin resistance, as highlighted by Lee et al 22 Purbowati et al, 9 stated that the administration of oyster mushroom extract at a dosage of 200 mg/kg body weight showed greater efficacy in lowering blood glucose levels. This result provided evidence of the impact of white oyster mushroom powder, rich in vitamin D, on reducing blood glucose.…”

Section: Resultsmentioning

confidence: 96%

“…8 Various types of mushrooms, such as maitake, shiitake, oyster, and other species, have high levels of vitamin D precursor when exposed to sunlight. 9 According to Hussana, 5 the exposure of oyster mushrooms to UV-B light increased the vitamin D2 level to more than 11 micrograms/gram. UV-B light exposure enhances vitamin D production in mushrooms without altering their nutritional composition, making the process safe to carry out.…”

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confidence: 99%

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The Potential of UV-B Irradiated Oyster Mushroom (Pleurotus ostreatus) Powder on Plasma Glucose and TNF-α Levels in Type 2 Diabetic Rats

2023

TJNPR

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Vitamin D deficiency is associated with various non-specific chronic diseases, including type 2 diabetes mellitus, cardiovascular diseases, cancer, and autoimmune disorders. 1 This health condition is a predisposition to insulin resistance as well as pancreatic β-cell damage, contributing to the growth of diabetes mellitus due to the importance of vitamin D pancreatic β-cells role, insulin sensitivity, and secretion. The vitamin D receptor directly activates insulin gene transcription, leading to increased insulin secretion and stimulating receptor expression, thereby improving insulin sensitivity. Indirectly, this vitamin also acts as a modulator of pancreatic β-cells to secrete an adequate amount of insulin. 2 Hyperglycemia in diabetic patients causes an increase in the production of ROS, which can cause oxidative tension. 3,4 The elevated production of ROS can lead to an increase in the term of Tumor Necrosis Factor-α (TNF-α), inducing oxidative stress and potentially causing life-threatening complications. 5 Hyperglycemia or high blood glucose levels result in inflammation, triggering a non-specific immune response that activates macrophages to release the proinflammatory cytokine TNFα. High levels of TNF-α also contribute to insulin resistance, causing endothelial dysfunction and complications in type two diabetes mellitus patients. 6

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Section: Resultsmentioning

confidence: 96%

mentioning

confidence: 99%

The Potential of UV-B Irradiated Oyster Mushroom (Pleurotus ostreatus) Powder on Plasma Glucose and TNF-α Levels in Type 2 Diabetic Rats

2023

TJNPR

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“…These results support previous studies, which stated that administering oyster mushroom powder and extract could reduce FBG levels and improve pancreatic beta cells in dia- o n l y betic rats. 32,33 Another in-vivo study in mice and rats fed with a high-fat diet showed that administering Pleurotus citrinopileatus and Pleurotus tuber-regium extracts could reduce fasting blood glucose levels. 19,34 Administering β-glucan from sources such as oats and chitin reduces FBG and HOMA-IR levels insulin secretion and repairs pancreatic beta cells.…”

Section: Resultsmentioning

confidence: 99%

“…β-glucan becomes a potent molecule to improve glucose homeostasis in the body through hypoglycemic effects, improvement of insulin resistance, and decreased apoptosis of pancreatic cells. 15,32,34 Decreased pro- inflammatory cytokines also improved insulin resistance, where low IL-6 and IL-1β increased the expression and sensitivity of insulin receptor substrate, specifically IRS-1. This resulted in increased insulin-mediated glucose uptake into cells.…”

Section: Resultsmentioning

confidence: 99%

β-(1,3)-D-glucan from <em>Pleurotus ostreatus</em> correlates with lower plasma IL-6, IL-1β, HOMA-IR, and higher pancreatic beta cell count in High-Fat and High-Fructose Diet (HFFD) rats

Innayah

Hariani²,

Khotimah³

et al. 2023

HEALTHC LOW-RESOUR S

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Introduction: The increasing consumption of high-fat and high-fructose foods contributes to the increasing prevalence of global obesity. Low-grade chronic inflammation in obesity is a significant risk factor for insulin resistance and type 2 diabetes. Therefore, this study aimed to determine the effect of β-(1,3)-D-glucan from oyster mushroom (Pleurotus ostreatus) extract on rats fed with a high-fat and high-fructose diet. Design and Methods: This experimental study was conducted on 35 male Sprague-Dawley rats aged eight weeks. The rats were divided into groups given a normal (N) diet, a high-fat and high-fructose diet (HFFD), D1 (HFFD+125 mg/kg BW β-glucan), D2 (HFFD+250 mg/kg BW β glucan), and D3 (HFFD+375 mg/kg BW β-glucan) with an intervention of 14 weeks. IL-6 and IL-1β levels were measured by the ELISA method, while HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) was calculated by the fasting insulin (ng/mL) x fasting blood glucose (mg/dL)/405 formula. Pancreatic beta-cell counts were measured by hematoxylin and eosin (H&E) staining. Results: The results showed no differences in IL-6 and IL-1β between the treatment groups. However, there were significant differences in HOMA-IR and pancreatic beta-cell counts between groups. There were negative correlations between the dose of β-glucan and IL-6, IL-1β, and HOMA-IR levels. Also, there was a positive correlation between the dose of β-glucan and the number of pancreatic beta cells. Conclusions: Administration of β-(1,3)-D-glucan from oyster mushroom (Pleurotus ostreatus) extract prevented hyperglycemia and insulin resistance, also reduced inflammation in rats fed with HFFD regardless of weight gain.

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“…After 5 days post-induction of STZ-NA, the rats fasted for eight hours before taking blood through the retro-orbital flexus. Rats with hyperglycemic conditions with fasting blood glucose levels >150 mg/dL and changes in lipid profile were used as study samples [28][29][30] .…”

Section: Experimental Animal Induction and Treatmentmentioning

confidence: 99%

Red Rice Bran Extract Intervention Ability to Improve Lipid Profile and Malondialdehyde Levels in Type 2 Diabetes Mellitus Model Rats

Dwijayanti

Wasita

Nurwati

2022

AMNT

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Background: Diabetes mellitus accompanied by oxidative stress can cause cardiovascular complications. Red rice bran extract contains antioxidants that have the potential to prevent oxidative stress and improve hyperlipidemia in patients with type 2 diabetes mellitus. Objectives: Analyzing the effect of red rice bran extract on lipid profile and malondialdehyde levels in a diabetes mellitus rat model. Methods: Pretest-Posttest Control Group Design. Thirty-five male Wistar Albino rats were divided into 5 groups, namely, negative control, positive control given acarbose as much as 1.8 mg/200gr/day, and 3 treatment groups given red rice bran extract, 165, 330, 660 mg/kg/day for 21 days, respectively. Results: There was a change in lipid profile and MDA levels (p<0.05) after the treatment of bran extract with doses of 165, 330, and 660 mg/kg BW/day. Red rice bran extract at a dose of 660 mg/kg BW/day can be an alternative to acarbose in reducing cholesterol, LDL, and MDA levels, as well as elevating HDL levels in type 2 diabetes mellitus rats. Conclusions: Red rice bran extract can significantly improve lipid profile and malondialdehyde levels in the type 2 diabetes mellitus rat model. Red rice bran extract at a dose of 660 mg/kg BW/day might be used as an alternative to acarbose in improving lipid profiles and MDA levels.

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Pengaruh jamur tiram putih (pleurotus ostreatus) terhadap kadar glukosa darah, profil lipid dan kadar MDA pada tikus (rattus norvegicus) diabetes melitus

Abstract: Background

Cited by 4 publications

References 6 publications

The Potential of UV-B Irradiated Oyster Mushroom (Pleurotus ostreatus) Powder on Plasma Glucose and TNF-α Levels in Type 2 Diabetic Rats

The Potential of UV-B Irradiated Oyster Mushroom (Pleurotus ostreatus) Powder on Plasma Glucose and TNF-α Levels in Type 2 Diabetic Rats

β-(1,3)-D-glucan from <em>Pleurotus ostreatus</em> correlates with lower plasma IL-6, IL-1β, HOMA-IR, and higher pancreatic beta cell count in High-Fat and High-Fructose Diet (HFFD) rats

Red Rice Bran Extract Intervention Ability to Improve Lipid Profile and Malondialdehyde Levels in Type 2 Diabetes Mellitus Model Rats

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