Pengaruh ekstrak kulit buah manggis Garcinia mangostana L.) terhadap kualitas spermatozoa tikus wistar (Rattus norvegicus) yang dipapari asap rokok

Wuisan, Milary; Tendean, Lydia; Rumbajan, Janette M.

doi:10.35790/ebm.4.1.2016.10865

Cited by 3 publications

(3 citation statements)

References 1 publication

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“…The hydroxyl radicals (•OH) formed when combined with unsaturated fatty acids (LH) will produce lipid radicals (L•) [21]. Lipid peroxidation can be prevented by flavonoids which are free radical scavengers, indicating that flavonoids react with peroxyl radicals (ROO*) and proceed to the autoxidation reaction termination stage [22]. In the adjuvant group, it was seen that A1, which was given the lowest dose of secang wood extract (50 mg/Kg BW) was most effective in reducing MDA levels by up to 47.84%.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity of Sappan Wood Extract (Caesalpinia sappan L.) As An Adjuvant and Substitution in Blood Serum of Rats (Rattus norvegicus) Iron Overload Model

Firdawati,

Kuntana,

Ghozali

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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Sappan (Caesalpinia sappan, L.) contains various antioxidant compounds such as brazilin and flavonoids that able to reduce superoxide anion radicals, reduce hydroxyl free radicals and chelate iron ions. This study aims to obtain the antioxidant activity of sappan wood extract which is given adjuvantly and substitution in blood serum of overload iron model rats. The research method used is experimental laboratory with a completely randomized design. The test animals were used 70 male rats aged 7 weeks weighing 200 grams and divided into normal, negative control, comparison, and experimental group. The adjuvant group used sappan wood extract at doses of 50, 100, 150, and 200 mg/kgBW. The subtitution group administred various percentages (25%, 50%, 75%, and 100%) of the sappan wood extract dose of 200 mg/kgBW. Data obtainedwere analyzed using one way ANOVA and Duncan’s test at 95% confidence level. The results showed that the administration of sappanwood extract at a dose of 50 mg/kg BW as an adjuvant and a dose of 200 mg/kg BW (100%) by substitution could provide better antioxidant activity against iron-excessed rat blood serum. This can be seen from the decreased activity of SOD, and levels of MDA and increased activity of GPX.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Activity of Sappan Wood Extract (Caesalpinia sappan L.) As An Adjuvant and Substitution in Blood Serum of Rats (Rattus norvegicus) Iron Overload Model

Firdawati,

Kuntana,

Ghozali

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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“…Lime peel contains flavonoids, vitamin C [7], which act as antioxidants, essential oils, alkaloids, saponins [8], terpenoids which act as antibacterials [9]. Based on previous research, it was explained that the ethanolic extract of orange (20 mg/ml) showed significant activity against clinical isolates of Shigella, Salmonella typhi, Klebsiella.…”

Section: Introductionmentioning

confidence: 99%

“…Studies show that Shigella is more sensitive to extracts with an average inhibition zone of 14.90 mm, followed by Klebsiella (14.49 mm), E. coli (13.77 mm) and S. typhi (12.01 mm) [10]. The ethanol extract of lime peel has potential as an anticancer [11], anticholesterol [12], antioxidant [7].…”

Section: Introductionmentioning

confidence: 99%

Utilization Of Lime Peel Waste (Citrus aurantifolia (Christm.) Swingle) As An Antibacterial Against Salmonella typhi

Simanjuntak¹

2023

Int J Ecophysiol

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Typhoid fever is a digestive tract infection caused by Salmonella typhi. Treatment of typhoid fever can use natural ingredients such as lime peel waste. The purpose of this study was to determine the effect of the ethanol extract of lime peel waste on the growth of Salmonella typhi bacteria. The extraction method used the maceration technique, and the antibacterial activity test used the paper disc diffusion method. The results showed that the ethanol extract of lime peel waste at concentrations of 1 mg/ml, 3 mg/ml, 5 mg/ml and 7 mg/ml with inhibition zone diameters of 4.66 mm, 6.55 mm, 9.29 mm and 10.06 mm. The conclusion shows that there is an effect of lime peel ethanol extract in inhibiting the growth of Salmonella typhi bacteria in the weak to strong category.

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Anthocyanins from Ipomoea batatas L. effect on ovarian malondialdehyde and 17β-estradiol in rats exposed cigarette smoke

et al. 2020

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Background — Cigarette smoking negatively impacts the health of both active smokers and passive smokers. ROS (Reactive Oxygen Species) from cigarette smoke can cause damage to the ovary and inhibit ovarian follicle growth. Objectives — This study aimed to assess the effects of the anthocyanins from the sweet potato (Ipomoea batatas L.) purple cultivar on ovarian malondialdehyde (MDA) and 17β-estradiol levels in rats (Rattus norvegicus) exposed to cigarette smoke. Material and Methods — The Rattus norvegicus Wistar strain was used in this study. Thirty rats were divided into five groups. Cigarette smoke was given as two cigarettes/day for four minutes, in the morning and afternoon for eight weeks after rats were at the proestrus stage. MDA levelwere measured with the BIOXYTECH MDA-586TM spectrophotometric assay for malondialdehyde, whilst 17β-estradiol was measured by ELISA. Data were then analyzed using one-way ANOVA. Results — MDA level were significantly different between the negative control and positive control groups based on double comparison with the LSD test (p=0.000 <∝). The level of 17β-estradiol also showed asignificant difference between the negative and positive control groups. There was a significant correlation between MDA level and 17β-estradiol levels (p=0.000 <∝) in the group of rats exposed to cigarette smoke and treated with anthocyanins from sweet potato at doses of 40 mg and 80 mg. Conclusions — Anthocyanins from the sweet potato (Ipomoea batatas L.) purple cultivar given at various doses decreased ovarian MDA level and increased 17β-estradiol levels in female rats exposed to cigarette smoke.

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Pengaruh ekstrak kulit buah manggis Garcinia mangostana L.) terhadap kualitas spermatozoa tikus wistar (Rattus norvegicus) yang dipapari asap rokok

Cited by 3 publications

References 1 publication

Antioxidant Activity of Sappan Wood Extract (Caesalpinia sappan L.) As An Adjuvant and Substitution in Blood Serum of Rats (Rattus norvegicus) Iron Overload Model

Antioxidant Activity of Sappan Wood Extract (Caesalpinia sappan L.) As An Adjuvant and Substitution in Blood Serum of Rats (Rattus norvegicus) Iron Overload Model

Utilization Of Lime Peel Waste (Citrus aurantifolia (Christm.) Swingle) As An Antibacterial Against Salmonella typhi

Anthocyanins from Ipomoea batatas L. effect on ovarian malondialdehyde and 17β-estradiol in rats exposed cigarette smoke

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