Penetrating trauma

Welsford, Michelle; Pardhan, Alim

doi:10.1002/9781118990810.ch29

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…2 The commonest cause of blunt chest injury has been reported to be road traffic crashes, although the incidence of penetrating chest injuries has also increased in civil society due to increasing the use of firearms, and other traditional weapons. 5 Associated injuries play an important role in determining the outcome of a chest injury patient especially when a head injury is associated. 6 The management has several essential elements, such as adequate prehospital care, rapid transport to a specialized center, complex in-hospital care, and rehabilitation.…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Pattern, and Management Outcomes of Chest Injury at Kilimanjaro Christian Medical Centre

2023

EAHRJ

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Background: Chest trauma is a major cause of morbidity and mortality in the region. Lacking data in our environment has been a challenging part of knowing the burden of the problem. Long hospital stays and associated injuries are an essential measure of morbidity. The study results will provide a basis for planning prevention strategies and establishment of treatment protocols. Objectives: To determine the prevalence, pattern, and management outcomes of chest injury patients at Kilimanjaro Christian Medical Center (KCMC), a Tertiary Hospital in Northern zone Tanzania from October 2021 to April 2022. Methodology: A hospital-based cross-sectional study was conducted among patients with chest injuries who were admitted and managed at Tertiary Hospital Northern Zone (Kilimanjaro Christian Medical Center-KCMC) in the Emergency medicine and General Surgery departments. Using a designated data collection tool, details of the mechanism of injury, radiological and laboratory investigations, management, and outcomes were recorded. Results: A total of 114 chest injury patients were studied. Males outnumbered females by a ratio of 7.14:1. Their ages ranged from 2 to 83 years (mean = 36.18 years). The Majority of patients (95.58%) sustained blunt injuries. Road traffic crush was the most common cause of injuries affecting 65.79% of patients. Lung contusion, hemothorax, and rib fractures were the most common type of injuries accounting for 54.4%, 27.2%, and 21.1%, respectively. Associated injuries were noted in 85.7% of patients, and head injury (60.5%) was found in most patients. The Majority of patients (60.5%) were treated successfully with a non-operative approach. Underwater seal drainage was performed at (38.9%). One Patient (0.9%) underwent a thoracotomy. 14% of patients had complications of surgical site infection, and 69% were found in the Majority of patients. The median length of hospital stay was 4.5 days. The mortality rate was 21% Conclusion: Motor traffic crash was the principal cause of chest trauma. Young male patients were most affected by chest trauma and the majority of patients were treated conservatively. Chest X-ray remains to be the main imaging modality for diagnosing thoracic trauma lesions. Associated injuries such as head injuries, were found to contribute to a high mortality rate.

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Section: Introductionmentioning

confidence: 99%

Prevalence, Pattern, and Management Outcomes of Chest Injury at Kilimanjaro Christian Medical Centre

2023

EAHRJ

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Airway Fibroblast Secretory Products Enhance Cell Migration

Jaulin

Idrus

Saim

et al. 2022

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Background: The nasal fibroblast secretome, which includes various cytokines, chemokines, and growth factors, promotes cell migration. Currently, the proteomics of airway fibroblast (AF) conditioned medium (AFCM) are being actively studied. Objective: This study was aimed at profiling and identifying the AF secreted proteins that can enhance wound healing of the airway epithelium and predict the potential pathway involved. Methods: Airway epithelial cells (AECs) and AFs were isolated from redundant human nasal turbinate and cultured. AFCM was collected by culturing the AFs either with serum-free airway epithelium basal medium (AECM) or with serum-free F12:DMEM (FDCM). For evaluating cell migration, the AECs were supplemented with airway epithelium medium and defined keratinocyte medium (1:1; AEDK; control), or with AEDK supplemented with 20% AECM or 20% FDCM. The mass spectrometry sample was prepared by protein precipitation, followed by gel electrophoresis and in-gel digestion. Results : AECM promoted better cell migration compared to the FDCM and the control medium. Bioinformatics analysis identified a total of 121, and 92 proteins from AECM and FDCM, respectively: 109 and 82 were identified as secreted proteins, respectively. STRING® analysis predicted that 23 proteins from the AECM and 16 proteins from the FDCM are involved in wound healing. Conclusion: Conditioned medium promotes wound healing by enhancing cell migration, and we successfully identified various secretory proteins in a conditioned medium that play important roles in wound healing.

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Penetrating trauma

Cited by 2 publications

References 19 publications

Prevalence, Pattern, and Management Outcomes of Chest Injury at Kilimanjaro Christian Medical Centre

Prevalence, Pattern, and Management Outcomes of Chest Injury at Kilimanjaro Christian Medical Centre

Airway Fibroblast Secretory Products Enhance Cell Migration

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