Penetrating scalp Marjolin's ulcer involving bone and dura mater in a Nigerian hospital: Case report and literature review

Onah, Ifeanyi Igwilo; Okwor, Bismark; Onuigbo, Wilson Ib

doi:10.1016/j.burns.2009.04.010

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…Among the 25 Marjolin's ulcer patients with skull invasion in the present study, 9 refused surgery and 5 received palliative surgery. Together, these groups represented 56% of the patients with skull invasion, which is similar to the percentage reported in a previous study (24). After the excision of Marjolin's ulcer, wound repair and functional reconstruction are key to improving life quality.…”

Section: Discussionsupporting

confidence: 89%

Clinical features and treatment of 140 cases of Marjolin's ulcer at a major burn center in southwest China

2019

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Marjolin's ulcer is a type of malignant tumor that occurs in scar tissue. The present study aimed to summarize and analyze the aetiology, clinical characteristics, treatment methods, metastasis and prognosis of this disease. A total of 140 cases of Marjolin's ulcer encountered at the Institute of Burn Research, Southwest Hospital (Chongqing, China) between January 2013 and December 2017 were retrospectively analyzed. Demographic data, clinical characteristics, occurrence of bone invasion and lymph node metastasis, as well as treatment and prognosis were statistically analyzed. Among the 140 patients, the initial injury or primary disease occurred at 1–75 years of age, while Marjolin's ulcer occurred at 15–85 years of age (mean, 53.3±1.2 years). The mean latency period was 28.8±1.7 years. The most common initial injury of the patients was flame burns, followed by skin masses, trauma, skin ulcerations caused by repeated scratching/friction, and scalding. The age at onset of initial injury or disease in patients had a significantly negative correlation with the latency period (P<0.01). The most common lesion locations were the lower limbs (42.1%), followed by the head, face and neck (34.5%). Of the 140 patients, 46 cases (32.9%) had bone invasion, 33 cases (23.6%) had lymph node enlargement and only 5 cases (3.6%) had lymph node metastasis. The skull was the bone that was most susceptible to Marjolin's ulcer invasion. The prevalence of bone invasion in patients with head, face and neck lesions was significantly higher than that in patients with lesions in other locations (P<0.01). The surgical methods applied were skin grafting, local flap repair, amputation and island flap repair. In the 65 cases who underwent follow-up, recurrence mainly occurred within 1 year after surgery. In conclusion, Marjolin's ulcer mainly occurred in males and was a scar carcinoma after a flame burn in most cases. Autologous skin grafting and local skin flap repair were the major repair methods. The peak period of recurrence was within one year after surgery and patients should receive regular follow-ups.

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Section: Discussionsupporting

confidence: 89%

Clinical features and treatment of 140 cases of Marjolin's ulcer at a major burn center in southwest China

2019

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“…In a review of over 1,100 burn injuries at the main referral hospital in Kenya, the average age was 12 years, with under-5-year-olds comprising 49% of the total [25]. Pediatric Marjolin's ulcers are very rare, with only a few cases reported in English literature [2,[26][27][28]. Acute Marjolin's ulcers are even rarer [29].…”

Section: Discussionmentioning

confidence: 99%

Marjolin’s Ulcers in sub‐Saharan Africa

Nthumba

2010

World j. surg.

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“…Repeated cycle of healing and breakdown, wound that never healed and application of irritant medication are all result in reduced ability to withstand carcinogens. (6) As a result of constant breakdown of ulcer, a nutritional deficiency develops, owing to release of toxins by autolysis and heterolysis of scar. This yields an epithelium that is unable to withstand the carcinogens produced by skin because of excessive heat and radiation.…”

Section: Literature Reviewmentioning

confidence: 99%

“…(8) It has also been suggested that relatively avascular scar tissue act as immune privileged site that allows the tumour to resist body defences against foreign cell. (6) Scar tissue acts as a barrier for the tumours, if we release this barrier, the virulent spread of the tumour will be permitted. (8) Regional lymph node metastasis and recurrence after surgery is not uncommon.…”

Section: Literature Reviewmentioning

confidence: 99%