Pendulaosides A and B. Two acylated triterpenoid saponins from Harpullia pendula seed extract

Ghaly, Neveen S.; Nabil, Marian; Grace, Mary H.; Melek, F. R.

doi:10.1016/j.phytol.2017.06.016

Cited by 5 publications

(7 citation statements)

References 18 publications

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“…5 The two ester moieties showed identical HMBC correlations to those previously reported by us for similar saponins bearing the same groups. 5 The HMBC correlations of the carbonyl carbons of the two ester groups at δ C 169. The α-glucosidase inhibitory activity of the two saponin mixture was evaluated in vitro.…”

Section: Resultssupporting

confidence: 81%

“…Previous examination of the major fraction by us, led to the isolation and characterization of the two saponins pendulaosides A and B. 5 In this report we described the characterization of two further new saponins 1 and 2 obtained as inseparable mixture from H. pendula. The negative high resolution LC-ESI-TOF-MS spectrum of 1 and 2 revealed the presence of two molecular ion peaks [M-H]at m/z 1041-5229 (C 52 H 81 O 21 ) and at m/z 1043.5415 (C 52 H 83 O 21 ), respectively.…”

Section: Resultsmentioning

confidence: 83%

“…12 Several acylated triterpenoid saponins with variable ester functions and sugar chains, were isolated and characterized from H. cupanioides, 2 H. austro-caledonica, 3 and H. pendula. 5 Flavonoids and phenolics from H. pendula were also reported. 5,13 Furthermore, two antimicrobial benzene acetic acid derivatives together with kaempferol glycosides were reported from H. pendula.…”

Section: Introductionmentioning

confidence: 98%

“…1 Previous investigations carried out on these plants proved them to be rich in polyhydroxylated triterpenoid saponins. [2][3][4][5] This type of saponins was reported to exhibit antimicrobial, [6][7][8] molluscicidal, miracidicidal and cercaricidal activities 9 as well as cytotoxic and Haemolytic properties. 4 Harpullia pendula Planch known as tulipwood or tuliplance wood is a small to medium rainforest tree native to Australia.…”

Section: Introductionmentioning

confidence: 99%

“…5,13 Furthermore, two antimicrobial benzene acetic acid derivatives together with kaempferol glycosides were reported from H. pendula. 14 As a part of our continuous investigations on bioactive saponins from plants cultivated in Egypt, 5 we described in this report the characterization of two further saponins from H. pendula.…”

Section: Introductionmentioning

confidence: 99%

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Two Triterpenoid Saponins with alpha-glucosidase Inhibitory Activity from Harpullia pendula Seed Extract

Nabil¹,

Ghaly²,

Kassem³

et al. 2019

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Background: Harpullia pendula Planch (family Sapindaceae) is a small to medium rainforest tree native to Australia. Objective: This study aims to isolate triterpenoid saponins from H. pendula and test them as α-glucosidase inhibitors. Materials and Methods: The saponin compounds were obtained using variable chromatographic techniques and characterized by spectral analysis. Results: Two new triterpenoid saponins were obtained as an inseparable mixture from H. pendula methanolic seed extract. Their structures were determined asbarrigenol, respectively. The triterpene part 22-O-(2-methyl butyroyl) A1-barrigenol has never been characterized before. The α-glucosidase inhibitory activity of the two saponin mixture was evaluated invitro and proved to exhibit strong activity with IC 50 value equals to 13.3 ± 5.0 ppm and IC 90 value equals to 21.5 ± 8.0 ppm. Conclusion: Two new saponins were characterized from their mixture and found to exhibit α-glucosidase inhibitory activity.

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Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 83%