Two Triterpenoid Saponins with alpha-glucosidase Inhibitory Activity from Harpullia pendula Seed Extract

Nabil, Marian; Ghaly, Neveen S.; Kassem, Iman A A; Grace, Mary H.; Melek, F. R.

doi:10.5530/pj.2019.11.214

Cited by 3 publications

(2 citation statements)

References 10 publications

(16 reference statements)

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“…Meanwhile, tannin lowers blood glucose with its ability to inhibit glucose-6phosphatase, increases glucose absorption in hepatocyte cells and myoblast cells, and acts as an inhibitor of the αglucosidase enzyme that can delay glucose absorption in the small intestine wall (Sheikh et al 2019). Saponin and flavonoids also can inhibit the α-glucosidase enzyme (Sohretoglu et al 2018;Nabil et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness test of Diploknema oligomera extracts to the decrease in glucose levels in alloxan-induced BALB/c male mice

FAIZAH,

ERIANI,

ROSNIZAR

2023

Nusantara Biosci

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Abstract. Faizah S, Eriani K, Rosnizar. 2023. Effectiveness test of Diploknema oligomera extracts to the decrease in glucose levels in alloxan-induced BALB/c male mice. Nusantara Bioscience 15: 143-148. People with diabetes mellitus usually consume chemical drugs to lower their blood glucose levels which cause side effects and require a reasonably high cost. Therefore, alternative natural medicines (phytopharmaceuticals) that are safer and more affordable are needed. Punti fruit (Diploknema oligomera H.J Lam) has the potential as an antihyperglycemic agent that can lower glucose levels in the blood because the punti fruit contains flavonoid compounds, tannins, terpenoids, and saponins. These secondary metabolites can reduce blood glucose levels. This research used an experimental method with a completely randomized design, six treatments, and four replications. This study used 24 BALB/C (Mus musculus Linnaeus, 1758) male mice grouped into six treatments, namely normal control treatment (P1), negative control by giving alloxan 150 mg/kg bw (P2), positive control by giving glibenclamide dose of 0.65 mg/kg body weight (bw) (P3), ethanol extract of punti fruit dose of 250 mg/kg bw (P4), ethanol extract of punti fruit dose of 500 mg/kg body weight (P5) and ethanol extract of punti fruit dose of 1,000 mg/kg bw (P6). The results proved that administering punti extract (P3, P4, P5) for 14 could reduce blood glucose levels in male diabetic mice with a percentage reduction of 33.6%, 37.4%, and 52.7%, and treatment-positive control decreased blood glucose by 32.6%. The conclusion showed that the ethanol extract of punti fruit at a dose of 1,000 mg/kg bw could effectively reduce blood glucose levels in diabetic mice compared to a dose of 250 mg/kg bw, 500 mg/kg bw and 0.65 mg/kg glibenclamide kg bw. Therefore, punti fruit can be used as a drug candidate to be developed as phytopharmaceuticals in treating diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Effectiveness test of Diploknema oligomera extracts to the decrease in glucose levels in alloxan-induced BALB/c male mice

FAIZAH,

ERIANI,

ROSNIZAR

2023

Nusantara Biosci

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“…Quinoa saponins possess a variety of biological and physiological properties, such as hypoglycemia, antioxidation, anti-cancer and antiinflammation [12][13][14][15]. Moreover, studies also suggest that the hypoglycemic effect of triterpenoid saponins is mainly due to their inhibition of α-glucosidase and improved β-cell function and insulin resistance [16,17]. Therefore, it is significant to explore a safe and efficient extraction method for quinoa saponins and develop the related health-benefiting functional products to promote the maximal utilization of quinoa husks.…”

Section: Introductionmentioning

confidence: 99%

Screening for α-Glucosidase-Inhibiting Saponins from Pressurized Hot Water Extracts of Quinoa Husks

Shi

et al. 2022

Foods

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The present study extracted total saponins from quinoa husks with pressurized hot water extraction and optimized the extraction conditions. The response surface methodology (RSM) with a Box–Behnken design (BBD) was employed to investigate the effects of extraction flow rate, extraction temperature and extraction time on the extraction yield of total saponins. A maximal yield of 23.06 mg/g was obtained at conditions of 2 mL/min, 210 °C and 50 min. The constituents of the extracts were analyzed by liquid chromatography–mass spectrometry (LC-MS). A total of twenty-three compounds were identified, including five flavonoids, seventeen triterpenoid saponins and a phenolic acid. Moreover, we performed an in vitro assay for the α-glucosidase activity and found a stronger inhibitory effect of the quinoa husk extracts than acarbose, suggesting its potential to be developed into functional products with hypoglycemic effect. Finally, our molecular docking analyses indicated triterpenoid saponins as the main bioactive components.

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Anti-diabetic potential of Chamaerops humilis L. aerial parts: Phenolic compounds with α-amylase and α-glucosidase inhibitory activates in-vitro, in-vivo and in-silico studies

Nabil,

Kassem,

Ghaly

et al. 2024

Journal of Molecular Structure

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Two Triterpenoid Saponins with alpha-glucosidase Inhibitory Activity from Harpullia pendula Seed Extract

Cited by 3 publications

References 10 publications

Effectiveness test of Diploknema oligomera extracts to the decrease in glucose levels in alloxan-induced BALB/c male mice

Effectiveness test of Diploknema oligomera extracts to the decrease in glucose levels in alloxan-induced BALB/c male mice

Screening for α-Glucosidase-Inhibiting Saponins from Pressurized Hot Water Extracts of Quinoa Husks

Anti-diabetic potential of Chamaerops humilis L. aerial parts: Phenolic compounds with α-amylase and α-glucosidase inhibitory activates in-vitro, in-vivo and in-silico studies

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