Pemphigus Vulgaris of the Cervix and Upper Vaginal Vault: A Cause of Atypical Papanicolaou Smears

Acantholytic Cells Exfoliated from Pemphigus Vulgaris of the Uterine Cervix

“…4,5 Involvement of the cervix in PV is quite rare, and so far only about 23 cases have been reported. [6][7][8][9][10][11][12][13][14][15][16][17][18][19] This could be due to the fact that most patients are asymptomatic and that the disease is usually managed by dermatologists, who rarely, if ever, perform routine vaginal examinations. In most published reports of cervical pemphigus, the patients already had concomitant or preceding lesions elsewhere on their bodies.…”

“…4,7 An increased nuclear/cytoplasmic ratio, prominent nucleoli and dense cytoplasm of the cells may lead to an erroneous diagnosis of intraepithelial or invasive malignancy. 14,18,19 However, the presence of a smooth nuclear membrane and absence of mitosis and necrotic diathesis should prevent misdiagnosis of a neoplastic lesion.…”

A Delayed Diagnosis: Pemphigus Vulgaris With Mucosal Involvement

“…Kadın genital mukozasının tutulumu ile ilgili bildiriler sınırlı sayıda olgu sunumu şeklindedir. 7,9,10 Yapı-lan az sayıdaki çalışmada farklı tutulum oranları bildirilmiş-tir. 3,11,12 Marren ve arkadaşları dokuz pemfigus vulgarisli hastanın dördünde vulva tutulumu olduğunu belirtirken 11 Malik ve Ahmed sadece genital bölge tutulumlu pemfiguslu hastalarla yaptıkları çalışmada pemfigusta genital tutulumun nadir olduğunu ve vajinal lezyonlardan ziyade vulva tutulumunun daha fazla olduğunu bildirmişlerdir.…”

Pemphigus Vulgaris

“…In most instances, the labia [ 32 ]. When the cervix is involved, some patients develop dyspareunia and cervical pemphigus may be misinterpreted as evidence of cervical dysplasia [ 33 ]. The mucosal surfaces that may be also involved with painful erosions include the nasal mucosa, penile skin, and anus [ 34 -37 ].…”