Acantholytic Cells Exfoliated from Pemphigus Vulgaris of the Uterine Cervix

Gupta, Sanjay; Sodhani, Pushpa; Jain, Shyama

doi:10.1159/000326609

Cited by 17 publications

(25 citation statements)

References 11 publications

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“…The best results were obtained with the Papanicolaou and HE methods ( Figure 1C), which identified the alterations reported by Gupta et al 18 for the uterine cervix, that is, a vesicular nucleus containing a nucleolus and well-defined cytoplasmic contours characterizing acantholytic cells. The presence of acantholysis associated with immunoglobulins in the intercellular spaces and on the cell membrane are diagnostic features.…”

Section: Pemphigus Vulgarissupporting

confidence: 70%

Evaluation of Staining Methods for Cytologic Diagnosis of Oral Lesions

Almeida¹,

Lima²,

Brandão³

et al. 2008

Acta Cytologica

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Section: Pemphigus Vulgarissupporting

confidence: 70%

Evaluation of Staining Methods for Cytologic Diagnosis of Oral Lesions

Almeida¹,

Lima²,

Brandão³

et al. 2008

Acta Cytologica

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“…There are other reports that cervical erosions were noted during colposcopies while the disease was quiescent elsewhere. 3,5,7 Subclinical cervical involvement has also been previously demonstrated with cervical smears, in the absence of cervical or vaginal pemphigus lesions. 6,9,14 In an earlier study of genital involvement, Malik and Ahmed 4 reported genital involvement in PV is rare and vulvar lesions occur more commonly than vaginal lesions.…”

Section: J Am Acad Dermatolmentioning

confidence: 67%

“…1,3,[5][6][7]13 Genital involvement usually occurs when other sites are extensively involved. 13 However, in a prior study, Chan et al reported 2 cases of PV in which the patients initially exhibited …”

Section: Discussionmentioning

confidence: 99%

“…Although previous reports have described PV involving the cervix and uterus, few studies have correlated the exact frequency of genital involvement in PV with cytologic findings and the disease's serologic status. [1][2][3][4][5][6][7][8][9][10][11] The current study was therefore designed to discern the frequency of genital involvement in PV and to determine the association between genital involvement and cervicovaginal Pap smear results, and with the disease's serologic status.…”

mentioning

confidence: 99%

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Genital involvement in pemphigus vulgaris (PV): Correlation with clinical and cervicovaginal Pap smear findings

Kavala¹,

Demir²,

Zindancı³

et al. 2015

Journal of the American Academy of Dermatology

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“…Gupta et al [13] and Lobo et al [15] described the atypical acantholytic cells of PV in cytological smears of the uterine cervix which were erroneously diagnosed as cervical cancer and atypical glandular cells of undetermined significance, respectively. They stated that in the absence of clinical suspicion of PV, atypical cells in cervical smears may be misinterpreted as metaplastic or malignant ones.…”

Section: Discussionmentioning

confidence: 99%

Pemphigus Vulgaris of Skin: Cytological Findings and Pitfalls

Mokhtari

Rasolmali²,

Kumar³

2012

Acta Cytologica

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Background: Pemphigus vulgaris (PV) is an autoimmune bullous lesion of the skin and mucous membranes characterized by suprabasal clefting and acantholysis. The responsible autoantibody is desmoglein 3, a protein constituent of the desmosome. The diagnosis of PV is based on histological examination and immunofluorescence study. In addition, cytological smears could also be informative for the initial diagnosis of PV. Cases: Fifteen patients, 7 men and 8 women, with skin bullous disease clinically suspected of being PV were selected for cytological study. The bullae were ruptured and two smears were prepared from the fluid and stained with the Wright-Giemsa and Papanicolaou methods. The smears were taken from both new and old bullae. They showed acantholytic cells (Tzanck cells), some with amoeboid-like cytoplasmic projections, eosinophils, basophils, various forms of typical and atypical lymphocytes with irregular nuclear borders and cerebriform nuclei and dysplastic acantholytic cells with a high nucleo-cytoplasmic ratio and prominent nucleoli. The dysplastic cells were seen only in the old bullae. Histological examination and immunofluorescence study of the lesions confirmed the diagnosis of PV. Conclusion: PV can be diagnosed by cytology. Without a clinical history of PV, the presence of atypical lymphocytes and dysplastic cells may lead to a false diagnosis of malignancy.

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Acantholytic Cells Exfoliated from Pemphigus Vulgaris of the Uterine Cervix

Cited by 17 publications

References 11 publications

Evaluation of Staining Methods for Cytologic Diagnosis of Oral Lesions

Evaluation of Staining Methods for Cytologic Diagnosis of Oral Lesions

Genital involvement in pemphigus vulgaris (PV): Correlation with clinical and cervicovaginal Pap smear findings

Pemphigus Vulgaris of Skin: Cytological Findings and Pitfalls

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