Genital involvement in pemphigus vulgaris (PV): Correlation with clinical and cervicovaginal Pap smear findings

Kavala, Mukaddes; Demir, Filiz Topaloğlu; Zindancı, İlkin; Can, Burçe; Türkoğlu, Zafer; Zemheri, Ebru; Çam, Osman Halit; Teksen, Ahmet

doi:10.1016/j.jaad.2015.06.057

Cited by 24 publications

(11 citation statements)

References 12 publications

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“…This is caused by the development of IgG autoantibodies against desmoglein 1 and/or 3 1. Varying frequencies of genital involvement in pemphigus vulgaris have been reported 2. Although genital involvement usually occurs when other sites are involved, there have been reports of isolated genital involvement with pemphigus vulgaris 2 3.…”

Section: Descriptionmentioning

confidence: 99%

“…Varying frequencies of genital involvement in pemphigus vulgaris have been reported 2. Although genital involvement usually occurs when other sites are involved, there have been reports of isolated genital involvement with pemphigus vulgaris 2 3. Differential diagnoses for vulval pemphigus vulgaris includes bullous pemphigoid, bullous tinea, Behcet’s disease, herpetic stomatitis and extra-cutaneous manifestations of granulomatous diseases, such as Crohn’s disease.…”

Section: Descriptionmentioning

confidence: 99%

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A rare cause of vulval swelling

2019

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Section: Descriptionmentioning

confidence: 99%

Section: Descriptionmentioning

confidence: 99%

A rare cause of vulval swelling

2019

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“…Patients can present with painful ulcerations of especially the buccal or palatine mucosa, but it can also present in the nose, genitals, anus, esophagus, and conjunctiva (Kavala et al 2015;Kavala et al 2011). In the skin, the bullae have a tendency to rupture, because the cellular interconnections are weakened by the autoimmune attack on desmogleins 1 and 3 (Stanley and Amagai 2006).…”

Section: Clinical Presentationmentioning

confidence: 99%

A brief review of pemphigus vulgaris

Sanders

2017

biomed dermatol

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Pemphigus vulgaris is an autoimmune disorder which presents with painful mucocutaneous blisters and erosions. On the skin, they are flaccid bullae or erosions, and on the mucosa, they present as erosions. This disease is rare but is devastating to those who have it; it also is related-perhaps genetically-to other autoimmune conditions. This is to say that a patient can develop pemphigus vulgaris if they have thyroiditis or diabetes mellitus. Biopsy is needed to obtain histopathological evidence of the breakdown of intercellular connections due to the autoimmune attack on components of desmosomes, which are responsible for intercellular integrity above the basement membrane. When these desmosomes are attacked, loss of connection ensues, and the cells break apart at these connections; this leads to fluid buildup, seen grossly as bullae. Treatment of the disease is difficult and sometimes unsafe. For decades, the mainstay of treatment has been glucocorticoids followed by other drugs. Unfortunately, these drugs are systemically absorbed, and the side effect profile can be unfavorable. In the past several years however, more innovative treatments have emerged that may help ease the cost and safety burden to patients. This review highlights the major points about pemphigus vulgaris, its pathophysiology, and its treatment.

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“…Moreover, it has been shown that there is a significant reduction in expression of desmogleins 1 and 3 in high-grade squamous intraepithelial lesions (SILs) as compared to low-grade SILs and normal cervix [3,10]. Cervical involvement in PV has been investigated in several studies [1,21,23,25,26,35]. Akhyani et al and Kavala et al reported that cervicovaginal Pap smear in 26 % (20/77) and 35 % (12/34) of female patients with PV, respectively, showed changes that were consistent with PV [1,21].…”

Section: Introductionmentioning

confidence: 99%

“…Cervical involvement in PV has been investigated in several studies [1,21,23,25,26,35]. Akhyani et al and Kavala et al reported that cervicovaginal Pap smear in 26 % (20/77) and 35 % (12/34) of female patients with PV, respectively, showed changes that were consistent with PV [1,21]. Lobo et al reported a female patient with PV who had multiple erosions on the cervix, which revealed intercellular deposits of IgG and complement (C) 3 on cervical epithelium by DIF technique [23].…”

Section: Introductionmentioning

confidence: 99%

Human cervix: an alternative substrate for detecting circulating pemphigus antibodies

et al. 2016

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Monkey esophagus (ME) is a well-accepted substrate for diagnosing pemphigus vulgaris (PV) by indirect immunofluorescence (IIF). However, its availability is sometimes limited due to ethical concerns. This study aimed to investigate the usefulness of human cervix (HC) as a substrate in the diagnosis of PV by IIF. Initially, serum from 1 PV patient was incubated with tissues from 48 HCs. Median IIF titers on HCs that had different demographic and clinical characteristics were compared. Sera from 5 PV patients were then incubated with ME and 21 HCs. For each serum, the titer of IIF on HC that was not different from ME by more than two-fold dilutions was acceptable. Last, sera from 42 PV, 14 pemphigus foliaceous, and 62 non-pemphigus patients were used to evaluate sensitivity and specificity. The results demonstrate that differences in demographic data among HCs did not affect IIF titers. Titers obtained from ME and HC were comparable (81-100 % acceptable values). Sensitivity of HC for diagnosis of PV was better than for diagnosis of pemphigus foliaceus (90.5 and 71.4 %, respectively). Specificity for PV and PF was 96.2 %. We proposed that HC substrate can be used as an alternative substrate for diagnosis of PV by IIF.

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Genital involvement in pemphigus vulgaris (PV): Correlation with clinical and cervicovaginal Pap smear findings

Cited by 24 publications

References 12 publications

A rare cause of vulval swelling

A rare cause of vulval swelling

A brief review of pemphigus vulgaris

Human cervix: an alternative substrate for detecting circulating pemphigus antibodies

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