Pemphigus vulgaris

Tamgadge, Sandhya; Tamgadge, Avinash; Bhatt, Daivat M; Bhalerao, Sudhir; Pereira, Treville

doi:10.4103/0976-237x.83074

Cited by 27 publications

(22 citation statements)

References 2 publications

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“…Autoreactive T‐helper I and T‐helper II cells specific for desmoglein 3 (Dsg 3) occur in PV and a synergistic interplay between these T cells leads to secretion of anti Dsg 3 autoantibody by B cells 28–31 . The binding of the autoantibodies to Dsg 3 generate a plethora of events leading to disruption of cell–cell adhesion and blister formation in PV 1,24 . Other than auto‐reactive antibodies, the proinflammatory cytokines TNF‐α, IL‐1 and IL‐6 enhance acantholysis by the induction of urokinase type plasminogen activator 32–34 .…”

Section: Discussionmentioning

confidence: 99%

“…Pemphigus vulgaris (PV) is an autoimmune blistering disorder of skin and mucous membranes with a strong immunogenetic link. The peak incidence of PV occurs between the fourth and sixth decades of life and it affects only 1–5 patients per million populations per year 1 . Lesions at first comprise small flaccid blisters giving rise to painful and hemorrhagic erosions.…”

Section: Introductionmentioning

confidence: 99%

“…The peak incidence of PV occurs between the fourth and sixth decades of life and it affects only 1-5 patients per million populations per year. 1 Lesions at first comprise small flaccid blisters giving rise to painful and hemorrhagic erosions. In most cases the first signs of disease appear on the oral mucosa; but the ulcerations may affect other mucous membranes including the conjunctiva, nasal mucosa, pharynx, larynx, esophagus and genital mucosa, as well as the skin.…”

Section: Introductionmentioning

confidence: 99%

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Macrophage migration inhibitory factor gene polymorphism is not associated with pemphigus vulgaris in Iranian patients

Saeedi

Amoli

Robati

et al. 2012

Acad Dermatol Venereol

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The result of this study using a large and well documented trial of patients showed that macrophage migration inhibitory factor -173G-C polymorphism is not associated with pemphigus vulgaris; but as the role of macrophage migration inhibitory factor in the inflammatory process has not been delineated in detail and the prevalence of C/C genotype is notably higher in our nation, this finding merits more consideration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Macrophage migration inhibitory factor gene polymorphism is not associated with pemphigus vulgaris in Iranian patients

Saeedi

Amoli

Robati

et al. 2012

Acad Dermatol Venereol

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“…The pemphigus group of disease is characterised by the production of autoantibodies against intercellular substances and is thus classified as autoimmune disease 7. The major PV autoantigen is desmoglein 3 (Dsg3), a desmosomal cadherin.…”

Section: Discussionmentioning

confidence: 99%

Pemphigus vulgaris - a report of three cases

et al. 2012

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Pemphigus vulgaris (PV) is a potentially life-threatening illness that manifests in the mouth and on skin. In a majority of patients it affects the oral mucosa and is sometimes difficult to diagnose when only mucosal involvement is present. In an attempt to highlight the proper treatment plan of this potentially fatal disorder, the authors document a report of three cases. These patients were prescribed conventional steroids which brought about partial relief but early recurrence with discontinuation of the drug. Subsequent management of these patients with azathioprine along with corticosteroids improved the outcome of the disease with longer remission periods. In this case series, the steroid sparing effect of azathioprine was achieved successfully and hence needs to be considered as a primary drug in management of PV.

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“…The drugs commonly implicated are those in the thiol group, in particular captopril, penicillamine, and others, such as rifampicin. 5 Desquamative gingivitis causes severe pain, thus interfering with appropriate oral hygiene leading to plaque accumulation. Dentists should be aware of these pathologies in order to diagnose them at an earlier stage and to direct patients for adequate treatment.…”

Section: Discussionmentioning

confidence: 99%

Pemphigus Vulgaris: Diagnosis with Oral Lesions

Singh¹,

Soni²,

Pereira³

et al. 2017

IJOCRWEB

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A 50-year-old patient reported to the dental college with the complaint of a blister and pain in the lower right back region since 2 months. The patient noticed slight bleeding and a blister associated with the lower right second molar on the gingiva 1 year back. He had visited a dentist where periodontal treatment, scaling and root planing were done. Initially, the bleeding subsided and the blister reduced in size but recurred after 6 to 7 months.Intraoral examination revealed localized erosions involving marginal and attached gingiva of the mandibular right first and second molar. Nikolsky's sign was positive, and the epithelium could be easily peeled away ( Fig. 1). Skin lesions were not present. Differential diagnosis of mucous membrane pemphigoid, erosive lichen planus, and PV was arrived at. A gingival biopsy was performed from the perilesional site of the involved gingiva and sent for histopathological examination.Histopathological examination showed acantholysis in the suprabasal region with a "suprabasillar split" (Fig. 2). Intraepithelial vesicle showed Tzanck cells. Connective tissue stroma was loose collagenous with dense inflammatory cells, confirming PV. Patient was asked to undergo Dsg 1 and Dsg 3 tests.Anti-Dsg 1 antibodies were 31.2 U/mL. Anti-Dsg 3 antibodies were 117.4 U/mL. ABSTRACTPemphigus vulgaris (PV) consists of a group of autoimmune blistering diseases of the skin and mucous membrane. The blisters occur in the epithelium where the patient's immunoglobulin G (IgG) autoantibodies are produced in response to triggering factors that target two structured proteins of desmosomes identified as desmogleins (Dsg) 1 and 3. It is essential that dentists should know these pathologies in order to be able to diagnose them at an early stage of the disease and to direct patients for adequate treatment. This article presents a case report along with its treatment plan.

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Pemphigus vulgaris

Cited by 27 publications

References 2 publications

Macrophage migration inhibitory factor gene polymorphism is not associated with pemphigus vulgaris in Iranian patients

Macrophage migration inhibitory factor gene polymorphism is not associated with pemphigus vulgaris in Iranian patients

Pemphigus vulgaris - a report of three cases

Pemphigus Vulgaris: Diagnosis with Oral Lesions

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