Pemphigus and Pemphigoid

Geographical Pattern of Pemphigus in North India

“…In our patients the morphology of the disease was clear cut so that hardly any difficulty was encountered in making a diagnosis. However, the age at onset of disease was relatively younger, i. e., between 20-40 years, which is strikingly different from those reported from other countries (10)(11)(12)(13)(14)(15). No variation in sex was observed, a finding largely in agreement with other studies.…”

“…A significant observation is, however, embodied in the successful therapy for the disease. Undoubtedly, prednisolone was a fundamental requisite for treatment, but the dosage needed for controlling the disease was much less in our patients than in those reported by other workers (11,(15)(16)(17)(18). Furthermore, most of the patients could be maintained on a dosage of 10-15mg daily.…”

Tuberous sclerosis underlying neonatal poliosis

“…Hypomelanotic macules are the most frequent and earliest cutaneous sign of tuberous sclerosis. 1 They appear in the first 6 months of life in 70% of cases, mainly affecting the trunk and the lower limbs. Head and neck are rarely involved.…”

“…Head and neck are rarely involved. 1 They are rarely present at birth and it is difficult to detect them in newborns with fair skin. However, a tuft of white hair (poliosis) at birth may be a useful sign for the early detection of tuberous sclerosis in newborns.…”

“…5 We can suggest that one or more tufts of white hair indicated the need to search for other signs of neonatal tuberous sclerosis, such as a cardiac rhabdomyoma or brain amarthomas. 1 Approximately 50% of MPNSTs arise from neurofibromas with or without neurofibromatosis type 1 (NF 1). 2 MPNSTs may manifest clinically with persistent pain, rapid enlargement and neurological deficit.…”