Ninety-eight patients having fixed drug eruptions were subjected to provocation tests. Cutaneous involvement was seen in 43, mucous membrane in 33 patients, while cutaneous and mucous membrane involvement was seen in 22 patients. The causative drugs were found to be trimethoprim-sulphamethoxazole (45), acetylsalicylic acid (24), hyoscine butylbromide (Buscopan®) (8), ibuprofen (Brufen®) (6), oxyphenbutazone (6), tetracycline hydrochloride (2), phenolphthalein (1) and phenobarbitone (1). There was evidence of cross-sensitivity between oxyphenbutazone and phenylbutazone.
Fixed eruptions are unusual in children. The classical type is easy to recognize, the generalized bullous variety is however often misdiagnosed. In the present study, 23 children with fixed eruptions were studied; of these, 8 had the generalized bullous type. Provocation tests were done in each case to identify the causative drugs. Acetylsalicylic acid (39%) was the commonest drug incriminated. The patients responded well to systemic steroids.
A school survey of pediculosis capitis in Benghazi, Libya, revealed an alarmingly high prevalence of 78.6%. The percentage of infestation was 67.2% for boys and 88.1% for girls. It was more frequent in schools located in rural areas (85.55%) as compared with those in urban areas (44.28%). There was no significant difference in infestation in younger and older children of either sex. Besides other factors for such a high prevalence, the lack of health education of family members may play a crucial role in transference and louse infestation.
Seventy one patients having fixed drug eruptions were subjected to provocation tests. The greatest number of cases were due to acetylsalicylic acid (18). Other drugs responsible were hyposcine butylbromide (15), oxyphenbutazone (14), sulphadiazine (7), tetracycline hydrochloride (6), metamizole (5) and ibuprofen (3). Other drugs were less frequent. There was evidence of cross sensitivity between various tetracyclines and sulphonamides and also between oxyphenbutazone and phenylbutazone. One patient had two groups oflesions, each reacting to a different, chemically unrelated drug.
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