Pemphigus

Bystryn, Jean‐Claude; Rudolph, Jennifer L.

doi:10.1016/s0140-6736(05)66829-8

Cited by 362 publications

(473 citation statements)

References 83 publications

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“…The accurate diagnosis of PV depends on three independent sets of criteria: clinical features, histology, and immunological tests 1. Through the use of these diagnostic processes, especially the clinical‐based first step, it is feasible to perform a simple, rapid, inexpensive, and noninvasive diagnostic test on cytological smears from oral lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Pemphigus vulgaris (PV) is a rare autoimmune disease that is characterized by acantholysis followed by blistering of the mucosa or skin 1. Although the initial onset of PV occurs in the oral mucosa (70–90%), it is subsequently observed in other mucosal sites such as the esophagus, pharynx, larynx, and genital or cutaneous lesions during the later stages 2, 3.…”

Section: Introductionmentioning

confidence: 99%

“…However, the final diagnosis of PV needs to be confirmed by a histological examination and immunofluorescence study 1, 5, 6. The main characteristic associated with PV cytopathologic findings is the presence of acantholytic cells.…”

Section: Introductionmentioning

confidence: 99%

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Oral pemphigus vulgaris: Liquid‐based cytological findings and pitfalls

Kondo

Kawashima

Kobata

et al. 2017

Diagnostic Cytopathology

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Pemphigus vulgaris (PV) is a chronic autoimmune bullous disease characterized by the formation of suprabasal cleavage and acantholysis. As this disease almost always affects the oral mucosa, conventional cytological smears of oral lesions can be used for the initial diagnosis of PV. We report two cases of PV that were initially diagnosed based on cytological smears of an oral sample. As atypical squamous cells were present even in the liquid‐based cytological (LBC) smears of the oral lesion in these two cases, this ultimately led to the misinterpretation of squamous cell carcinoma. These findings demonstrate that cytological mimicry of oral PV can occur in malignant cases when there is an absence of appropriate clinical information.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oral pemphigus vulgaris: Liquid‐based cytological findings and pitfalls

Kondo

Kawashima

Kobata

et al. 2017

Diagnostic Cytopathology

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“…This process leads to the formation of a cleft within the epidermis, which then enlarges into a bulla, which then breakdown into coalescing ulcers. 14,15 All forms of pemphigus are associated with the presence of circulating and fixed autoantibodies-referred to as intercellular antibodies-against keratinocyte cell-surface antigens. It is most common in the fourth and fifth decades and equally affects males and females.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of pemphigus incidence in the Bhuj, Kutch, Gujarat: a cross-sectional study

Parmar¹,

Patel

2017

Int J Res Dermatol

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Background: Pemphigus is a group of rare skin disorders that cause blisters and sores on the skin or mucous membranes, such as in the mouth or on the genitals. In Brazil, the prevalence of the disorder is 3.4% in regions such as the Amerindian reservation of Limão Verde and approximately 15,000 patients are known to have pemphigus foliaceus. This prompted us to conduct a study to estimate the incidence of pemphigus in the central Bhuj district of the state of Gujarat in India.Methods: The present study was planned and conducted between January 2016 to December 2016. The entire team of dermatologists licensed in the district were included in the study and full efforts were made to reach out to them. All the participating dermatologists were asked to fill up a simple perform prepared by the experts in the field. The Performa included the details like date, investigations required for pemphigus, diagnosis based for pemphigus.Results: The total population of Bhuj district is estimated to be 5 millions. At the end of the study period that is one year, all the collected performa from the licensed dermatologist were evaluated and results were prepared accordingly. A total of 24 patients who fulfilled all the inclusion criteria were included in the study. Conclusions: This original research proves that the incidence of pemphigus in Bhuj district was 7.2 per million in the period of one year. This incidence is much higher than the incidence rates reported from the Germany where only 14 cases were reported over a period of 8 years. This study does give us a preliminary idea about the incidence of this rare disease in this geographic area.

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“…9,10,[16][17][18][19] Ocular involvement has been reported as a signal of severe disease and tends to occur several months after the onset of skin or other mucosal lesions. 6 However, there is evidence to suggest that ocular symptoms can precede the onset of skin and mucus membrane lesions, 11,[20][21][22] suggesting that ocular involvement may be underdiagnosed. In their series of 11 patients with ocular PV, Hodak et al 9 reported that eight patients (72.7%) had symptoms of ocular irritation, tearing, and foreign body sensation before the development of oral or cutaneous lesions.…”

Section: Discussionmentioning

confidence: 99%