Pemanfaatan Ekstrak Daun Mangrove (Rhizophora mucronata sp.) dengan Variasi Pelarut Sebagai Bahan Aktif Sediaan Farmasi Terapi Anti Kanker

Abstract

This research was done to study mangrove leaves (Rhizophora mucronata sp.) utilization in the Cilacap regency brackish waters. The research goal is to make nano emulsion from mangrove plants as an alternative to increase the economic value of mangrove. This research method has 2 phases. In the first phase, mangrove leaves was extracted using various solvent. In the second phase mangrove leaves extract was formulated as nano emulsion as anti-cancer treatment along as an alternative to increase mangrove leaves economic value. Extraction results of mangrove leaves using various solvent such as hexane, ethyl acetate and ethanol show that using ethanol p.a solvent with the young leaves of mangrove giving the highest amount extract as much as 18.24%.
 Mangrove leaves extract nano emulsion can be prepared using Self-Nano Emulsifying Drug Delivery System (SNEDDS) technique. The SNEDDS technique nano emulsion formulation started with 14 formulas. The best formula from this study was using Tween 80 : PEG 400 : Fish Oil as much as 6 ml: 1 ml: 1 ml dosage ratio. Using the best formula, it was added with 5 mg of mangrove leaves extract. The result test of Drug Loading, calculation of Emulsification Time and Dissolution test show that mangrove leaves extract has the potential to be used as an active substance anti-cancer on nano emulsion manufacturing.

Overview of bioactivity studies on marine natural products

“…can have the potential as antibacterial agents because it contains steroid compounds, triterpenoids, flavonoids, alkaloids and polyphenols [20]. The type of seagrass Holothuria edulis which contains triterpenoids has potential as antibacterial [21]. Seaweed species Caulerpa sp., Euchema sp., Gracilaria sp., and Sargassum sp.…”

UJI AKTIVITAS ANALGESIK EKSTRAK DAUN MANGROVE (Rhizophora mucronata) PADA MENCIT YANG DIINDUKSI ASAM ASETAT DENGAN METODE WRITHING REFLEX

“…Daun mangrove Rhizophora mucronata L. yang digunakan pada penelitian ini dibuat ekstrak kental untuk menghindari kejenuhan pelarut dan memaksimalkan pengambilan zat aktif dengan pelarut polar yang terkandung dalam simplisia, sehingga rendemen ekstrak yang didapatkan maksimal (Faoziyah & Kurniawan, 2017). Penelitian ini menggunakan pelarut etanol 70% untuk menyari metabolit sekunder daun mangrove karena etanol bersifat polar sehingga mampu mengekstraksi senyawa flavonoid, tannin dan saponin.…”

Phytochemistry and Anticancer Effects of Mangrove (Rhizophora mucronata Lam.) Leaves and Stems Extract against Different Cancer Cell Lines

“…Additionally, the fruit flour of ripe R. mucronata may be used for diabetic patients [ 20 ], and its leaves may be used as an antidiarrheal medication [ 21 ]. R. mucronata contains several biologically active compounds, such as phenolics, alkaloids, steroids, saponins, flavonoids, tannins, triterpene, and diterpenoids [ 22 ]. R. mucronata has been studied in vitro and has proven to be able to inhibit the growth of cancer cells, including cervical [ 23 ], breast [ 24 ], and colon cancer cells [ 25 ].…”