Pelvic Pain Alters Functional Connectivity Between Anterior Cingulate Cortex and Hippocampus in Both Humans and a Rat Model

Yu, Wenjun; Wu, Xiaoyan; Chen, Yunan; Liang, Zhiying; Jiang, Jinxiang; Misrani, Afzal; Su, Yun-Ai; Peng, Yigang; Chen, Jian; Tang, Binliang; Sun, Mengyao; Long, Cheng; Shen, Jun; Yang, Li

doi:10.3389/fnsys.2021.642349

Cited by 8 publications

(5 citation statements)

References 90 publications

(131 reference statements)

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“…Functional magnetic resonance imaging (fMRI) technology provides a new dimension in pain assessment [ 47 ]. fMRI has been used in clinical trials and animal studies related to pain [ 48 , 49 ]. These limitations should be considered in future studies.…”

Section: Discussionmentioning

confidence: 99%

Curcumin alleviates orofacial allodynia and improves cognitive impairment via regulating hippocampal synaptic plasticity in a mouse model of trigeminal neuralgia

Zhi,

Jia,

et al. 2023

Aging

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Objective: Cognitive impairment, one of the most prevalent complications of trigeminal neuralgia, is troubling for patients and clinicians due to limited therapeutic options. Curcumin shows antinociception and neuroprotection pharmacologically, suggesting that it may have therapeutic effect on this complication. This study aimed to investigate whether curcumin alleviates orofacial allodynia and improves cognitive impairment by regulating hippocampal CA1 region synaptic plasticity in trigeminal neuralgia. Methods: A mouse model of trigeminal neuralgia was established by partially transecting the infraorbital nerve (pT-ION). Curcumin was administered by gavage twice daily for 14 days. Nociceptive thresholds were measured using the von Frey and acetone test, and the cognitive functions were evaluated using the Morris water maze test. Dendritic spines and synaptic ultrastructures in the hippocampal CA1 area were observed by Golgi staining and transmission electron microscopy. Results: Curcumin intervention increased the mechanical and cold pain thresholds of models. It decreased the escape latency and distance to the platform and increased the number of platform crossings and dwell time in the target quadrant of models, and improved spatial learning and memory deficits. Furthermore, it partially restored the disorder of the density and proportion of dendritic spines and the abnormal density and structure of synapses in the hippocampal CA1 region of models. Conclusion: Curcumin alleviates abnormal orofacial pain and cognitive impairment in pT-ION mice by a mechanism that may be related to the synaptic plasticity of hippocampal CA1, suggesting that curcumin is a potential strategy for repairing cognitive dysfunction under long-term neuropathic pain conditions.

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Section: Discussionmentioning

confidence: 99%

Curcumin alleviates orofacial allodynia and improves cognitive impairment via regulating hippocampal synaptic plasticity in a mouse model of trigeminal neuralgia

Zhi,

Jia,

et al. 2023

Aging

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“…Depression is not uncommon in DR patients and it has a negative impact on their condition. However, in recent years, an increasing amount of evidence from electrophysiology[ 43 ], functional imaging[ 44 ], and behavioral studies[ 45 ] have shown that the ACC is closely related to the management of pain. The ACC can be activated by nociceptive and contextual stimuli, and it can participate in pain management, especially affective pain.…”

Section: Discussionmentioning

confidence: 99%

Altered spontaneous brain activity patterns in patients with diabetic retinopathy using amplitude of low-frequency fluctuation

Shi¹,

Zhang²,

Tang³

et al. 2022

WJD

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BACKGROUND Diabetes mellitus is a metabolic disorder characterized by prolonged elevation of blood glucose due to various causes. Currently, the relationship between diabetic retinopathy (DR) and altered connectivity of brain function is unclear. AIM To investigate the relationship between this brain activity and clinical manifestations and behaviors of DR patients by using the amplitude of low-frequency fluctuation (ALFF) technique. METHODS Twenty-four DR patients and 24 healthy controls (HCs) matched for age and gender were enrolled. We measured and recorded average ALFF values of DR patients and HCs and then classified them using receiver operating characteristic (ROC) curves. RESULTS ALFF values of both left and right posterior cerebellar lobe and right anterior cingulate gyrus were remarkably higher in the DR patients than in the HCs; however, DR patients had lower values in the bilateral calcarine area. ROC curve analysis of different brain regions demonstrated high accuracy in the area under the curve analysis. There was no significant relationship between mean ALFF values for different regions and clinical presentations in DR patients. Neuronal synchronization abnormalities in some brain regions of DR patients were associated with cognitive and visual disorders. CONCLUSION Abnormal spontaneous brain activity was observed in many areas of DR patients’ brains, which may suggest a possible link between clinical manifestations and behaviors in DR patients.

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“…Fornix forms efferent projection fibers of the hippocampus and also comprises commissural fibers connecting the hippocampus of both sides (5,10,(17)(18)(19)(20)(21)(22)(23)(24).…”

Section: Fornixmentioning

confidence: 99%

The Anatomy of the Hippocampus

Chauhan

Jethwa²,

Rathawa

et al. 2021

Cerebral Ischemia

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The hippocampal formation is responsible for memory processing, learning, spatial navigation, and emotions. It includes the indusium griseum, longitudinal striae, gyrus fasciolaris, hippocampus proper (cornu ammonis, dentate gyrus, and subiculum) and part of the uncus. The hippocampus has the archipallial cortex and is formed by the infoldings of the dentate gyrus, cornu ammonis and subiculum. The dentate gyrus is a narrow crenated strip of grey matter. The dentate gyrus consists of three layers, from the outside in: the molecular layer, granular layer, and polymorphic layer. The granular neurons receive input from the parahippocampal gyrus (entorhinal cortex) via the perforant pathway. The granular neurons send mossy fibers to the apical dendrites of pyramidal cells present in the cornu ammonis.The axons of hippocampal pyramidal cells form a sheet of white fibers known as the alveus which continues as fimbria and fornix. The fornix projects into the septal area. From the 2 septal area few fibers synapse into the cingulate gyrus which returns to the hippocampus. The neuronal intrinsic circuit, known as the Papez circuit of the hippocampus, plays a crucial role in the memory processing.

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Pelvic Pain Alters Functional Connectivity Between Anterior Cingulate Cortex and Hippocampus in Both Humans and a Rat Model

Cited by 8 publications

References 90 publications

Curcumin alleviates orofacial allodynia and improves cognitive impairment via regulating hippocampal synaptic plasticity in a mouse model of trigeminal neuralgia

Curcumin alleviates orofacial allodynia and improves cognitive impairment via regulating hippocampal synaptic plasticity in a mouse model of trigeminal neuralgia

Altered spontaneous brain activity patterns in patients with diabetic retinopathy using amplitude of low-frequency fluctuation

The Anatomy of the Hippocampus

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