Pelvic Inflammatory Disease and Fertility

Weström, L; Joesoef, Riduan; Reynolds, Gladys H.; Hagdu, Alula; Thompson, Sumner E.

doi:10.1097/00007435-199207000-00001

Cited by 680 publications

(131 citation statements)

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“…Urogenital infections are the leading cause of bacterial sexually transmitted disease (3) in both industrialized and developing nations (4). Moreover, sexually transmitted diseases are risk factors for infertility (5), the transmission of HIV (6), and human papilloma virus-induced cervical neoplasia (7). Control of C. trachomatis infections is an important public health goal.…”

mentioning

confidence: 99%

Chlamydia trachomatispolymorphic membrane protein D is a species-common pan-neutralizing antigen

Crane¹,

Carlson²,

Fischer

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

143

140

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Infections caused by the obligate intracellular pathogen Chlamydia trachomatis have a marked impact on human health. C. trachomatis serovariants are the leading cause of bacterial sexually transmitted disease and infectious preventable blindness. Despite decades of effort, there is no practical vaccine against C. trachomatis diseases. Here we report that all C. trachomatis reference serotypes responsible for sexually transmitted disease and blinding trachoma synthesize a highly conserved surface-exposed antigen termed polymorphic membrane protein D (PmpD). We show that Ab specific to PmpD are neutralizing in vitro. We also present evidence that Ab against serovariable-neutralizing targets, such as the major outer membrane protein, block PmpD neutralization. This finding suggests that a decoy-like immune evasion strategy may be active in vivo whereby immunodominant type-specific surface antigens block the neutralizing ability of species-common PmpD Ab. Collectively, these results show that PmpD is a previously uncharacterized C. trachomatis species-common pan-neutralizing target. Moreover, a vaccine protocol using recombinant PmpD to elicit neutralizing Ab in the absence of immunodominant type-specific Ab might be highly efficacious and surpass the level of protection achieved through natural immunity.Chlamydia ͉ autotransporter ͉ neutralizing target ͉ surface antigen ͉ vaccine

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mentioning

confidence: 99%

Chlamydia trachomatispolymorphic membrane protein D is a species-common pan-neutralizing antigen

Crane¹,

Carlson²,

Fischer

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

143

140

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show abstract

“…The current prognosis is 99%+ survival and less than 1% death (Lurie 1992). A recent study in Sweden (Weström et al 1992) indicated that occluded fallopian tubes significantly decreased the chances for a successful attempt at becoming pregnant, and, if pregnancy did occur, also (significantly) increased the chances of an ectopic pregnancy by at least a factor of six (Table 1).…”

Section: Stds Are Not Benign Occurrencesmentioning

confidence: 99%

Pair-Bonding and the Evolutionary Trajectory of Homo: Disease Avoidance as an Adaptive Trait

Immerman¹,

Mackey²

2003

JEA

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“…Furthermore, PID may be confused with other pelvic conditions that exhibit similar symptoms, such as endometriosis, appendicitis or ectopic pregnancy. Owing to the serious reproductive morbidity associated with PID [12,13,[16][17][18][19][20], a low threshold for both diagnosis and treatment is recommended. The following minimum criteria have been proposed by the US CDC: uterine/adnexal tenderness or cervical motion tenderness [21].…”

Section: Pelvic Inflammatory Disease Diagnosismentioning

confidence: 99%

Diagnosis and Treatment of Pelvic Inflammatory Disease

Haggerty

Ness

2008

Womens Health (Lond Engl)

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Pelvic inflammatory disease (PID), the infection and inflammation of the female upper genital tract, is a common cause of infertility, chronic pain and ectopic pregnancy. Diagnosis and management are challenging, largely resulting from varying signs and symptoms and a polymicrobial etiology that is not fully delineated. Owing to the potential for serious sequelae, a low threshold for diagnosis and treatment is recommended. As PID has a multimicrobial etiology, including Neisseria gonorrhoeae, Chlamydial trachomatis and anaerobic and mycoplasmal bacteria, treatment of PID should consist of a broad spectrum antiobiotic regimen. Recent treatment trials have focused on shorter duration regimens, such as azithromycin, and monotherapies including ofloxacin, but data are sparse. Research comparing sequelae development by differing antimicrobial regimens is extremely limited, but will ultimately shape future treatment guidelines.

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Pelvic Inflammatory Disease and Fertility

Cited by 680 publications

References 0 publications

Chlamydia trachomatispolymorphic membrane protein D is a species-common pan-neutralizing antigen

Chlamydia trachomatispolymorphic membrane protein D is a species-common pan-neutralizing antigen

Pair-Bonding and the Evolutionary Trajectory of Homo: Disease Avoidance as an Adaptive Trait

Diagnosis and Treatment of Pelvic Inflammatory Disease

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