Pellagra as the Presenting Manifestation of Crohn's Disease

Pollack, Shirley; Enat, R; Haim, S; Zinder, Oren; Barzilai, D

doi:10.1016/s0016-5085(82)80260-6

Cited by 33 publications

(12 citation statements)

References 14 publications

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“…CD is associated with decreased absorption of niacin and seems to have a role in developing this nutritional disorder. A review of the literature confirms the paucity of reports of pellagra as a complication of CD . The three “Ds” of pellagra were observed in our patient, and this association is present in only 22% of patients .…”

Section: Discussionsupporting

confidence: 82%

Isoniazid‐induced pellagra in a patient with Crohn's disease

Kchir

Yacoub

Hassine

et al. 2020

Clinical Case Reports

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Section: Discussionsupporting

confidence: 82%

Isoniazid‐induced pellagra in a patient with Crohn's disease

Kchir

Yacoub

Hassine

et al. 2020

Clinical Case Reports

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“…Crohn disease 80,81 Jejuno-ileitis 55,82 Gastroenterostomy 55,82 Subtotal gastrectomy 55 Chronic colitis 41 Severe ulcerative colitis 41 Regional ileitis 83 Hepatic cirrhosis 84 Gastrointestinal tract tuberculosis 41 Coeliac disease 41 Metabolic 'steal' Carcinoid syndrome 85 membranous furrows, erosions or ulcers; later, it becomes atrophic with diminution of its papillae. 11 There is also tenderness, swelling and fragility of gum and oral mucous membranes.…”

Section: Malabsorptionmentioning

confidence: 99%

“…This section describes the main features of the single congenital form of niacin deficiency and the multiple acquired variants (Table 4). 27,41,55,72–94 …”

Section: Clinical Variants Of Niacin Deficiencymentioning

confidence: 99%

Pellagra: a review with emphasis on photosensitivity

Wan

Moat

Anstey

2011

British Journal of Dermatology

148

147

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Niacin has recently been demonstrated to lower blood pressure in hypertensive patients and to reduce cardiovascular events when combined with a statin. As a consequence, niacin has been elevated from being of historical interest as the treatment for pellagra, to being a compound with possible relevance to contemporary therapeutics. In spite of this, niacin deficiency leading to pellagra continues to be a health problem in some countries. Characterized by an exposed-site hyperpigmented dermatitis, pellagra is generally accepted to have been the first photosensitivity syndrome described. At its worst, pellagra manifests as one of the most striking examples of systemic photosensitivity. This is the only photosensitivity syndrome where death is included as a cardinal clinical feature (the often quoted four 'Ds': dermatitis, diarrhoea, dementia and death). However, the pathogenetic mechanism for the photosensitivity caused by niacin deficiency has yet to be determined. This review seeks to update the classification and phenotypic characterization of the various forms of niacin-deficient photosensitivity. Previous speculation about possible mechanisms for the pathogenesis of photosensitivity due to niacin deficiency is reviewed in the context of advances in the understanding of the photochemical basis of photosensitivity reactions. The review concludes by highlighting research required to advance the understanding of this photosensitivity syndrome.

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“…Deficiency of nicotinic acid may lead to the clinical manifestations of pellagra. This has now been reported in four patients with Crohn's disease (49)(50)(51)(52)(53). The cutaneous lesions are scaly, dusky red plaques found symmetrically at sites exposed to trauma and to the sun, especially the dorsa of the hands, the V of the neck, face, and elbows.…”

Section: Nutritional Disorders Affecting the Skinmentioning

confidence: 74%

“…The erythematous plaques are well demarcated and may become deeply pigmented. The cause of the deficiency in one such patient was demonstrated by an abnormal nicotinic acid-loading test to be a defect in the absorption of nicotinic acid by the ileum (50). The rash should resolve completely with the administration of nicotinamide.…”

Section: Nutritional Disorders Affecting the Skinmentioning

confidence: 97%

Cutaneous Changes Associated with Inflammatory Bowel Disease

Paller

1986

Pediatric Dermatology

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Inflammatory bowel disease often begins during adolescence, but may affect younger children. Associated skin lesions are not uncommon. Occasionally, cutaneous alterations may precede the onset of signs or symptoms of the gastrointestinal disorder. Erythema nodosum and pyoderma gangrenosum are the most common associated specific skin changes, but numerous others may be found. Although the skin condition often responds to treatment of the bowel, it may require additional therapy.

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Pellagra as the Presenting Manifestation of Crohn's Disease

Cited by 33 publications

References 14 publications

Isoniazid‐induced pellagra in a patient with Crohn's disease

Isoniazid‐induced pellagra in a patient with Crohn's disease

Pellagra: a review with emphasis on photosensitivity

Cutaneous Changes Associated with Inflammatory Bowel Disease

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