Isoniazid‐induced pellagra in a patient with Crohn's disease

Abstract

Isoniazid preventive therapy in malnourished patients with Crohn's disease has a potential of inducing pellagra but still a very rare situation. No cases of isoniazidinduced pellagra in patients with Crohn's disease were reported in the literature.Pellagra can be easily treated if timely diagnosed.

Pellagra a review exploring causes and mechanisms, including isoniazid‐induced pellagra

“…The risk of developing pellagra in HIV patients with latent TB who were given Isoniazid prophylaxis has been commented on 17 . Isoniazid reduces niacin levels in two ways: it inhibits its intestinal absorption and inhibits its endogenous production from tryptophan 18 . Essentially, the human body treats the structurally similar isoniazid as if it were niacin and so behaves as if niacin concentrations are sufficient.…”