PEGylation of protein-imprinted nanocomposites sandwiching CdTe quantum dots with enhanced fluorescence sensing selectivity

Han, Xiaopeng; Han, Wenyan; Zhang, Shiting; Liu, Zhiqiang; Fu, Guoqi

doi:10.1039/c9ra08556d

Cited by 18 publications

(5 citation statements)

References 44 publications

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“…It is well known that surface PEGylation can effectively restrain non-specific binding. 51 Thus, we firstly tried a PEG-derived silane coupling agent for surface functionalization of the original SiO 2 NPs, together with these after etched with 80 mM of NH 4 HF 2 for comparison. The surface of the etched SiO 2 NPs was more coarse than the untreated, as seen from the SEM images (Fig.…”

Section: Resultsmentioning

confidence: 99%

Controlled synthesis of open-mouthed epitope-imprinted polymer nanocapsules with a PEGylated nanocore and their application for fluorescence detection of target protein

Feng

Jin

et al. 2022

RSC Adv.

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Section: Resultsmentioning

confidence: 99%

Controlled synthesis of open-mouthed epitope-imprinted polymer nanocapsules with a PEGylated nanocore and their application for fluorescence detection of target protein

Feng

Jin

et al. 2022

RSC Adv.

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“…Han, Xiao, et al, combined the fluorescence of QDs with SiO 2 nanoparticles having molecularly imprinted polymers (MIPs) layer with bovine hemoglobin (BHb) as a model protein template [170]. Briefly, SiO 2 /CdTe nanoparticles were functionalized with MIP nanolayers by the sol-gel process and PEG chains were grafted onto the surface of the imprinted MIP layer via nucleophilic reaction of the surface amine groups with PEG-NHS, followed by template removal.…”

Section: Biosafety Of Quantum Dots (Qd)mentioning

confidence: 99%

Biosafety of inorganic nanomaterials for theranostic applications

et al. 2022

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Recent advances in inorganic nanomaterial-based theranostics enabled imaging-guided molecular targeting and drug delivery, and various combinations of theranostic systems. The term “theranostics” is defined as diagnosis processed with therapy simultaneously with a specific connection between therapy and diagnosis. The inorganic nanomaterials, representatively carbon, metal, ceramic, and semiconductor-based nanomaterials, exhibit their unique characteristics to be used in theranostic applications. However, the unveiled human biosafety of nanomaterials for clinical use has become a major concern. Therefore, in this review, we compiled recent research on in vitro and in vivo biosafety of inorganic nanomaterials in various theranostic applications, along with a discussion of how the particle formulation, size, surface functionalization, test species, and test condition affect biocompatibility. Furthermore, the progress and challenges of the development of biocompatible inorganic nanomaterials for theranostic applications were discussed. In conclusion, with appropriate precautions on the biosafe condition to be administered, inorganic nanomaterials can be proposed to have excellent potential in the future theranostic application.

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“…This is due to the large molecular volume, complex structure, and flexible conformation of proteins 10–12 . In view of the specificity of protein structure, researchers have developed different strategies for protein imprinting, including epitope imprinting, 13–15 surface imprinting, 16–18 the introduction of stimulus‐responsive functional monomers or cross‐linking agents 19–21 and anti‐protein adsorption segments, 22–24 and so on.…”

Section: Introductionmentioning

confidence: 99%

Anti‐nonspecific adsorption segments‐assisted self‐driven surface imprinted fibers for efficient protein separation

Yang

Wang

et al. 2022

AIChE Journal

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At present, the development of high-performance protein imprinted materials is still a research hotspot in the field of protein imprinting. Herein, anti-protein adsorption segment (CBMA)-assisted self-driven bovine serum albumin (BSA) surface imprinted fibers MTCFs@SIP@CBMA with high recognition selectivity are pioneered using the strategies of combining magnetic nanomaterial surface imprinting technique with amino-Michael addition. The special structure of the carrier MTCFs endows MTCFs@SIP@CBMA with magnetic performance and self-driven adsorption performance, which simplifies the separation process while improving the adsorption capacity and accelerating the adsorption rate. The adsorption capacity for BSA reached 390 ± 20 mg/g within 30 min. The introduction of CBMA segments on the surface after imprinting by amino-Michael addition makes its polymer chain length and position controllable. Under the strongest anti-nonspecific adsorption effect, MTCFs@SIP@CBMA exhibit excellent specific identification to BSA from mixed proteins. Additionally, MTCFs@SIP@CBMA show considerable reusability. Therefore, MTCFs@SIP@CBMA are expected to be applied in efficient separation of proteins in biological samples.

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PEGylation of protein-imprinted nanocomposites sandwiching CdTe quantum dots with enhanced fluorescence sensing selectivity

Abstract: PEGylated CdTe quantum dots containing protein-imprinted nanocomposites showing enhanced fluorescence sensing selectivity.

Cited by 18 publications

References 44 publications

Controlled synthesis of open-mouthed epitope-imprinted polymer nanocapsules with a PEGylated nanocore and their application for fluorescence detection of target protein

Controlled synthesis of open-mouthed epitope-imprinted polymer nanocapsules with a PEGylated nanocore and their application for fluorescence detection of target protein

Biosafety of inorganic nanomaterials for theranostic applications

Anti‐nonspecific adsorption segments‐assisted self‐driven surface imprinted fibers for efficient protein separation

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