Abstract:Here,
we explore whether PEGylation of antibodies can modulate
their biodistribution to the eye, an organ once thought to be immune
privileged but has recently been shown to be accessible to IV-administered
large molecules, such as antibodies. We chose to PEGylate an anti-MerTK
antibody, a target with known potential for ocular toxicity, to minimize
biodistribution to retinal pigment epithelial cells (RPEs) in the
eye by increasing the hydrodynamic volume of the antibody. We used
site-specific conjugation to a… Show more
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