Engineered therapeutic proteins for sustained-release drug delivery systems

Nguyen, Thoa Thi Kim; Pham, Khang-Yen; Yook, Simmyung

doi:10.1016/j.actbio.2023.09.018

Cited by 6 publications

(1 citation statement)

References 299 publications

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“…These have some minor limitations, such as low bioavailability, short half-life, and susceptibility to enzymatic degradation. Therefore, these are mostly administered through the parenteral route. − In a study, peptide conjugated with Doxorubicin micelles coated with hyaluronic acid for enhanced tumor targeting showed reduced tumor volume when injected into xenograft mice models, also drug release pattern was based on the differences in pH of the tumor microenvironment . Thus, using various nanoparticles to deliver therapeutic peptides in combination with chemotherapeutic drugs will be more effective in treating complex diseases.…”

Section: Introductionmentioning

confidence: 99%

Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies

Buddhiraju,

Yadav,

Dey

et al. 2023

ACS Appl. Bio Mater.

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Peptides are ideal biologicals for targeted drug delivery and have also been increasingly employed as theranostic tools in treating various diseases, including cancer, with minimal or no side effects. Owing to their receptor-specificity, peptidemediated drug delivery aids in targeted drug delivery with better pharmacological biodistribution. Nanostructured self-assembled peptides and peptide−drug conjugates demonstrate enhanced stability and performance and captivating biological effects in comparison with conventional peptides. Moreover, they serve as valuable tools for establishing interfaces between drug carriers and biological systems, enabling the traversal of multiple biological barriers encountered by peptide−drug conjugates on their journeys to their intended targets. Peptide-based drugs play a pivotal role in the field of medicine and hold great promise for addressing a wide range of complex diseases such as cancer and autoimmune disorders. Nanotechnology has revolutionized the fields of medicine, biomedical engineering, biotechnology, and engineering sciences over the past two decades. With the help of nanotechnology, better delivery of peptides to the target site could be achieved by exploiting the small size, increased surface area, and passive targeting ability of the nanocarrier. Furthermore, nanocarriers also ensure safe delivery of the peptide moieties to the target site, protecting them from degradation. Nanobased peptide delivery systems would be of significant importance in the near future for the successful targeted and efficient delivery of peptides. This review focuses on peptide−drug conjugates and nanoparticle-mediated self-assembled peptide delivery systems in cancer therapeutics.

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Section: Introductionmentioning

confidence: 99%