Pegylated tetraarylporphyrin entrapped in liposomal membranes

Kępczyński, Mariusz; Nawalany, Kinga; Jachimska, Barbara; Romek, M.; Nowakowska, Maria

doi:10.1016/j.colsurfb.2006.02.008

Cited by 41 publications

(21 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reversed micelles (RMs) are spatially ordered macromolecular assembly of surfactants formed in a nonpolar solvent, in which the polar head groups of the surfactants point inward and the hydrocarbon chains point toward the nonpolar medium 1–3. Vesicles and liposomes are spherical aggregates formed by some amphiphilic compounds, in which the lipid bilayer surrounds an aqueous void volume that can be “loaded” with almost any variety of water‐soluble marker molecules 4. 5 To prepare large unilamellar vesicles (LUVs), application of different techniques (such as ultrasonication or extrusion) to convert multilamellar vesicles (formed spontaneously) into LUVs are mandatory 6.…”

Section: Methodsmentioning

confidence: 99%

A Unique Ionic Liquid with Amphiphilic Properties That Can Form Reverse Micelles and Spontaneous Unilamellar Vesicles

Villa¹,

Moyano²,

Ceolı́n³

et al. 2012

Chemistry A European J

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

A Unique Ionic Liquid with Amphiphilic Properties That Can Form Reverse Micelles and Spontaneous Unilamellar Vesicles

Villa¹,

Moyano²,

Ceolı́n³

et al. 2012

Chemistry A European J

View full text Add to dashboard Cite

show abstract

“…The most commonly used ligand is poly(ethylene glycol) (PEG), a hydrophilic polymer that curtails recognition and uptake by the RES to maintain effective blood concentration. These modified liposomes exhibit protein resistance, minimum toxicity and non-immunogenicity [ 102 , 103 ]. Nawalany et al reported the use of pegylated liposomes to reduce tetrakis (4-hydroxyphenyl) porphyrin (p-THPP) aggregation in the treatment of prostate adenocarcinoma cell line (DU 145) and human colon adenocarcinoma cell line (HCT 116) [ 103 ].…”

Section: Organic Nanoparticlesmentioning

confidence: 99%

Drug Carrier for Photodynamic Cancer Therapy

Debele

Peng

Tsai

2015

IJMS

205

169

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is a non-invasive combinatorial therapeutic modality using light, photosensitizer (PS), and oxygen used for the treatment of cancer and other diseases. When PSs in cells are exposed to specific wavelengths of light, they are transformed from the singlet ground state (S0) to an excited singlet state (S1–Sn), followed by intersystem crossing to an excited triplet state (T1). The energy transferred from T1 to biological substrates and molecular oxygen, via type I and II reactions, generates reactive oxygen species, (1O2, H2O2, O2*, HO*), which causes cellular damage that leads to tumor cell death through necrosis or apoptosis. The solubility, selectivity, and targeting of photosensitizers are important factors that must be considered in PDT. Nano-formulating PSs with organic and inorganic nanoparticles poses as potential strategy to satisfy the requirements of an ideal PDT system. In this review, we summarize several organic and inorganic PS carriers that have been studied to enhance the efficacy of photodynamic therapy against cancer.

show abstract

“…Poly (ethylene glycol)-5-(4-hydroxy methyl-phenyl)-10,15,20-tritolylporphyrin (PEG 8000 -Po) (M n ¼ 8 000 Da) with the same, as in the case of PMA-Po, porphyrin chromophores at the end of the polymeric chain was obtained by the method described in literature. [3] Series of pegylated 5,10,15,20tetrakis(4-hydroxyphenyl)porphyrin with PEG chains of 350, 2000 and 5000 Da were synthesized as described in literature. [4,5] Model Studies In order to determine the effect of attachment of polymer chain on physicochemical and photophysical properties of Po as well as its ability to interact with liposomes the model studies were performed.…”

Section: Experimental Partmentioning

confidence: 99%

Novel Nanostructural Hybride Materials for Photodynamic Theraphy

Nowakowska

Nawalany

Kępczyński

et al. 2009

Macromolecular Symposia

Self Cite

View full text Add to dashboard Cite

Photodynamic theraphy (PDT) is a clinically approved method for treatment of cancer and some other diseases. It employs the combination of a drug (photosensitizer) and light to induce photoxicity towards the cancerous cells. The efficiency of currently used photosensitizers is limited due to their aggregation in aqueous media and low chemical purity; usually a mixture of various isomers is used. This paper presents the results of our studies on the development of nanostructural materials for PDT. They are constructed from porphyrin (Po) which is covalently attached to the chain of hydrophylic polymer such as poly(methacrylic acid) (PMA) or poly(ethylene glycol) (PEG) and solubilized in lipid bilayer of liposome vesicles. The attachment of Po to the polymer chain improves its solubility in water while the solubilization in liposome carriers helps the dye to penetrate the cell membranes. Physicochemical and photophysical properties of those systems were determined. The in vitro studies on cancer cell lines demonstrated that the photosensitizers are efficiently accumulated in the cells. Their dark toxicity is negligible, while phototoxicity is very high.

show abstract

Pegylated tetraarylporphyrin entrapped in liposomal membranes

Cited by 41 publications

References 26 publications

A Unique Ionic Liquid with Amphiphilic Properties That Can Form Reverse Micelles and Spontaneous Unilamellar Vesicles

A Unique Ionic Liquid with Amphiphilic Properties That Can Form Reverse Micelles and Spontaneous Unilamellar Vesicles

Drug Carrier for Photodynamic Cancer Therapy

Novel Nanostructural Hybride Materials for Photodynamic Theraphy

Contact Info

Product

Resources

About