PEGylated nanoparticles for biological and pharmaceutical applications

Abstract

The utility of polymeric micelles formed through the multimolecular assembly of block copolymer was comprehensively described as novel core-shell typed colloidal carriers for drug and gene targeting. Particularly, novel approaches for the formation of functionalized poly(ethylene glycol) (PEG) layers as hydrophilic outer shell were focused to attain receptormediated drug and gene delivery through PEG-conjugated ligands with a minimal non-specific interaction with other proteins. Surface organization of block copolymer micelles with cross-linking core was also described from a standpoint of the preparation of a new functional surface-coating with a unique macromolecular architecture. The micelle-attached surface and the thin hydrogel layer made by layered micelles exhibited nonfouling properties and worked as the reservoir for hydrophobic reagents. Furthermore, the potential utility of multimolecular assembly derived from heterobifunctional PEGs and block copolymers were explored to systematically modify the properties of metal and semiconductor nanostructures by controlling their structure and their surface properties, making them extremely attractive for use in biological and biomedical applications. 

Green synthesis of silver nanoparticles mediated by Pulicaria glutinosa extract

“…[1][2][3] For instance, the unique optoelectronic and physicochemical properties of metal NPs have already been successfully exploited for the purpose of drug delivery, 4 tissue/tumor imaging, and plant extracts. [11][12][13][14] Among the most important bioreductants are plant extracts, which are relatively easy to handle, readily available, low cost, and have been well explored for the green synthesis of other nanomaterials.…”

Fabricating bio-inspired micro/nano-particles by polydopamine coating and surface interactions with blood platelets

“…On the one hand, the particle size is not well-controlled during surface engineering [14]. On the other hand, the conventional method for surface modification results in heterogeneous surface on a particle [15]. Therefore, the facile method to fabricate micro/nano-particles with controllable size and surface properties is highly desired.…”

Mitsunobu Reaction: A Versatile Tool for PEG End Functionalization

“…Poly(ethylene glycol) (PEG) is widely applied for its extremely low protein adsorption and toxicity in a variety of systems including PEGylated liposomes, [ 1 ] nanoparticles and micelles, [ 2 ] and therapeutic proteins [ 3 ] ; some of them have found clinical use and obtained Food and Drug Administration (FDA) approval (liposomes such as Doxil, Lipoplatin in cancer treatment; PEGylated proteins such as Krystexxa, PEGASYS, Cimzia, Macugen, predominantly for the treatment of infl ammatory pathologies. [ 4 ] Although some alternatives exist, e.g., the polyPEG approach, [ 5 ] most PEGylation approaches employ appropriately reactive end groups that participate in reactions such as the Michael-type addition of amines, [ 6 ] …”