PEGylated NaLuF4: Yb/Er upconversion nanophosphors for in vivo synergistic fluorescence/X-ray bioimaging and long-lasting, real-time tracking

Yi, Zhigao; Lü, Wei; Xu, Yaru; Yang, Jing; Deng, Li; Qian, Chao; Zeng, Tianmei; Wang, Haibo; Rao, Ling; Liu, Hongrong; Zeng, Songjun

doi:10.1016/j.biomaterials.2014.08.021

Cited by 54 publications

(29 citation statements)

References 57 publications

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“…Zeng and co-workers prepared PEG-modified NaLuF 4 :Yb,Er UCNPs for synergistic UCL/XI study. 588 A Kunming mouse was injected subcutaneously with UCNPs and underwent simultaneous UCL and XI. As compared to the untreated mouse, high-contrast X-ray absorption signals were observed in regions that were injected UCNPs.…”

Section: Lanthanide Nanoparticles For Dual-and Multimode Imagingmentioning

confidence: 99%

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

et al. 2015

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Section: Lanthanide Nanoparticles For Dual-and Multimode Imagingmentioning

confidence: 99%

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

et al. 2015

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“…Another paper has reported the use of PEGylated NaLuF 4 which allows for the combination of fluorescence and X-ray imaging[158]. …”

Section: Choice Of Elements For Spectral Ct Contrast Materialsmentioning

confidence: 99%

Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral CT technologies

Yeh

Fitzgerald

Edic

et al. 2017

Advanced Drug Delivery Reviews

158

144

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The introduction of spectral CT imaging in the form of fast clinical dual-energy CT enabled contrast material to be differentiated from other radiodense materials, improved lesion detection in contrast-enhanced scans, and changed the way that existing iodine and barium contrast materials are used in clinical practice. More profoundly, spectral CT can differentiate between individual contrast materials that have different reporter elements such that high-resolution CT imaging of multiple contrast agents can be obtained in a single pass of the CT scanner. These spectral CT capabilities would be even more impactful with the development of contrast materials designed to complement the existing clinical iodine- and barium-based agents. New biocompatible high-atomic number contrast materials with different biodistribution and X-ray attenuation properties than existing agents will expand the diagnostic power of spectral CT imaging without penalties in radiation dose or scan time.

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“…1,2 The absence of such a modality drives the development of multimodality imaging, which has become a hot topic and has led to the development of imaging technology. 3 If the imaging information is used to guide therapy as imaging-guided noninvasive therapy, the distribution and evolution of tumor/drug could be seen with time- and position-resolved modes, while the therapeutic efficiency and safety are also improved. Quantum dots and inorganic nanoparticles have been designed for multimodality imaging through the integration of various imaging modalities but they suffer from high biological toxicity and complicated preparation procedures.…”

Section: Introductionmentioning

confidence: 99%

“…Quantum dots and inorganic nanoparticles have been designed for multimodality imaging through the integration of various imaging modalities but they suffer from high biological toxicity and complicated preparation procedures. 3 The development of novel multimodality imaging-guided therapy platforms is still a long-lasting aspiration for scientists and clinicians.…”

Section: Introductionmentioning

confidence: 99%