PEGylated NaHoF4 nanoparticles as contrast agents for both X-ray computed tomography and ultra-high field magnetic resonance imaging

Ni, Dalong; Zhang, Jiawen; Bu, Wenbo; Zhang, Chen; Yao, Zhenwei; Xing, Haibo; Wang, Jing; Duan, Fei; Liu, Yanyan; Fan, Wenpei; Feng, Xiaoyuan; Shi, Jianlin

doi:10.1016/j.biomaterials.2015.10.063

Cited by 94 publications

(93 citation statements)

References 41 publications

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“…7e). 21 Both experimental and theoretical findings revealed that Curie contribution to contrast enhancement was the principal mechanism when particle size was smaller than 7 nm (Fig. 7f and g), as the φ ( τ D ) value from Curie relaxation remarkably decreased with increasing diffusion correlation time ( τ D ) from 1 ns (3 nm NaHoF 4 ) to 5 ns (7 nm NaHoF 4 ).…”

Section: Factors Influencing Relaxivity Of Mri Contrast Agentsmentioning

confidence: 82%

“…70 Among all lanthanide ions, Dy 3+ (together with Ho 3+ ) has the highest effective magnetic moment ( μ eff = 10.6 μ B ) and much attention has been paid to synthesizing Dy 3+ - or Ho 3+ -based NPs as T 2 CAs, 70-72 especially for ultra-high field imaging. 19-21,73 Studies of d -glucuronic acid-coated ultra-small Ln 2 O 3 NPs (Ln = Eu, Gd, Dy, Ho, or Er) show that Gd 2 O 3 NPs exhibit the highest r 1 value, whereas Dy 2 O 3 NPs possess the highest r 2 value among all studied NPs. 74 Unlike the lanthanides, iron is one of the most abundant metal elements in living organisms and deeply involved in various biological processes including cellular respiration by redox enzymes and oxygen transport by hemoglobin.…”

Section: Basic Rules For Mri Contrast Agentsmentioning

confidence: 95%

“…Great efforts have been made for the rational design and manufacture of NPs with high relaxivity to elevate imaging sensitivity of CAs and even impart MRI with molecular imaging capabilities for better monitoring of biological processes ( e.g ., tumor microenvironment, cell tracking, and cellular interactions). This has resulted in the wide expansion of this research area, leading to the formation of sub-branches such as ultra-high field MRI, 19-21 multi-modal imaging, 22-24 and incorporation of theranostic techniques into MRI. 25 …”

Section: Introductionmentioning

confidence: 99%

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Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

et al. 2017

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Magnetic resonance imaging (MRI) is a highly valuable non-invasive imaging tool owing to its exquisite soft tissue contrast, high spatial resolution, lack of ionizing radiation, and wide clinical applicability. Contrast agents (CAs) can be used to further enhance the sensitivity of MRI to obtain information-rich images. Recently, extensive research efforts have been focused on the design and synthesis of high-performance inorganic nanoparticle-based CAs to improve the quality and specificity of MRI. Herein, the basic rules, including the choice of metal ions, effect of electron motion on water relaxation, and involved mechanisms, of CAs for MRI have been elucidated in detail. In particular, various design principles, including size control, surface modification (e.g. organic ligand, silica shell, and inorganic nanolayers), and shape regulation, to impact relaxation of water molecules have been discussed in detail. Comprehensive understanding of how these factors work can guide the engineering of future inorganic nanoparticles with high relaxivity. Finally, we have summarized the currently available strategies and their mechanism for obtaining high-performance CAs and discussed the challenges and future developments of nanoparticulate CAs for clinical translation in MRI.

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Section: Factors Influencing Relaxivity Of Mri Contrast Agentsmentioning

confidence: 82%

Section: Basic Rules For Mri Contrast Agentsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

et al. 2017

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“…Multifunctional nanomaterial-mediated fluorescence imaging 1-3, photoacoustic imaging 4-6, magnetic resonance imaging (MRI) 7-9, positron emission computed tomography (PET) imaging 10-12 and X-ray computed tomography (CT) imaging 13, 14 for more precise diagnosis of tumors have attracted ever-increasing attention. In addition, emerging nanomedicine in cancer therapy such as photothermal 1, 15, 16, photoacoustic 4, 6, 17, photodynamic 18-20, magnetic thermal 9, 21, 22, ultrasonic hyperthermia 23, 24, radiation therapy 25, 26 and microwave thermal therapy 27 have evoked great interest in their potential clinical application for cancer diagnostics and therapeutics research.…”

Section: Introductionmentioning

confidence: 99%

Thermoacoustic Imaging and Therapy Guidance based on Ultra-short Pulsed Microwave Pumped Thermoelastic Effect Induced with Superparamagnetic Iron Oxide Nanoparticles

Wen¹,

Yang²,

Zhong³

et al. 2017

Theranostics

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Multifunctional nanoparticle-mediated imaging and therapeutic techniques are promising modalities for accurate localization and targeted treatment of cancer in clinical settings. Thermoacoustic (TA) imaging is highly sensitive to detect the distribution of water, ions or specific nanoprobes and provides excellent resolution, good contrast and superior tissue penetrability. TA therapy is a potential non-invasive approach for the treatment of deep-seated tumors. In this study, human serum albumin (HSA)-functionalized superparamagnetic iron oxide nanoparticle (HSA-SPIO) is used as a multifunctional nanoprobe with clinical application potential for MRI, TA imaging and treatment of tumor. In addition to be a MRI contrast agent for tumor localization, HSA-SPIO can absorb pulsed microwave energy and transform it into shockwave via the thermoelastic effect. Thereby, the reconstructed TA image by detecting TA signal is expected to be a sensitive and accurate representation of the HSA-SPIO accumulation in tumor. More importantly, owing to the selective retention of HSA-SPIO in tumor tissues and strong TA shockwave at the cellular level, HSA-SPIO induced TA effect under microwave-pulse radiation can be used to highly-efficiently kill cancer cells and inhibit tumor growth. Furthermore, ultra-short pulsed microwave with high excitation efficiency and deep penetrability in biological tissues makes TA therapy a highly-efficient anti-tumor modality on the versatile platform. Overall, HSA-SPIO mediated MRI and TA imaging would offer more comprehensive diagnostic information and enable dynamic visualization of nanoagents in the tumorous tissue thereby tumor-targeted therapy.

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“…Fe 3 O 4 /TaO X core-shell NPs can be designed and used for simultaneous T 2 -weighted MR and CT imaging of tumors [26]. Likewise, PEGylated NaHoF 4 NPs can be synthesized and used as contrast agents for both CT and ultrahigh field T 2 -weighted MR imaging of tumors [34]. In addition, dendrimers modified with gadolinium (Gd) chelator can be used as templates to synthesize Au NPs, followed by chelation of Gd(III) for dual-mode CT/MR imaging of blood pool and major organs of animals [35].…”

mentioning

confidence: 99%

PEGylated Polyethylenimine-Entrapped Gold Nanoparticles Loaded With Gadolinium For Dual-Mode Ct/Mr Imaging Applications

Zhou

Xiong

Zhu

et al. 2016

Nanomedicine (Lond.)

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PEGylated NaHoF4 nanoparticles as contrast agents for both X-ray computed tomography and ultra-high field magnetic resonance imaging

Cited by 94 publications

References 41 publications

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Thermoacoustic Imaging and Therapy Guidance based on Ultra-short Pulsed Microwave Pumped Thermoelastic Effect Induced with Superparamagnetic Iron Oxide Nanoparticles

PEGylated Polyethylenimine-Entrapped Gold Nanoparticles Loaded With Gadolinium For Dual-Mode Ct/Mr Imaging Applications

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