PEGylated Polyethylenimine-Entrapped Gold Nanoparticles Loaded With Gadolinium For Dual-Mode Ct/Mr Imaging Applications

Abstract

The designed Gd@Au PENPs may be used as a versatile nanoplatform for dual-mode CT/MR imaging of different biological systems.

Combined Magnetic Resonance Imaging and Photodynamic Therapy Using Polyfunctionalised Nanoparticles Bearing Robust Gadolinium Surface Units

“…Most clinically used contrast agents are based on paramagnetic (4f 7 ) gadolinium(III) ions, which interact with water molecules to improve the relaxation rates of the protons, enhancing the image contrast . The immobilisation of trivalent gadolinium units on the surface of gold nanoparticles dramatically increases the relaxation rate experienced by the protons of the water molecules in their vicinity . This can be partly traced to the effect on the rotational correlation time, which increases when the assembly rotates slowly, leading to greatly increased relaxivity per Gd 3+ ion.…”

“…This can be partly traced to the effect on the rotational correlation time, which increases when the assembly rotates slowly, leading to greatly increased relaxivity per Gd 3+ ion. In addition to this intrinsic enhancement, the presence of many gadolinium ions creates a multimeric effect on the relaxation of water protons due to the increased localised contrast agent concentration …”

“…[15] The immobilisation of trivalent gadolinium units on the surfaceo fg old nanoparticles dramatically increases the relaxation rate experienced by the protons of the water molecules in their vicinity. [16][17][18][19][20][21][22][23][24][25][26][27][28][29] This can be partlyt raced to the effect on the rotational correlation time, which increases when the assembly rotatess lowly,l eading to greatly increased relaxivity per Gd 3 + ion. In addition to this intrinsic enhancement, the presence of many gadolinium ions createsamultimeric effect on the relaxation of water protons due to the increased localised contrasta gent concentration.…”

Effect of surface modification with various thiol compounds on colloidal stability of gold nanoparticles

“…In recent decades, one of the most interesting fields in nanoscience has been metallic nanoparticles such as iron oxide, silver, gold, etc. Gold nanoparticles (AuNPs) are colloidal and stable ones widely employed in contemporary nanoscience applications such as chemical and biological sensing, medical diagnostics and therapeutics and biological imaging because of their strong surface plasmon resonance (SPR) absorption band in the visible region . The position of the SPR band depends on the size and shape of nanoparticles, their environment, aggregative state and interparticle distance .…”

Influence of gold nanoparticles on wound healing treatment in rat model: Photobiomodulation therapy

“…Metal-based nanomaterial is currently getting much attention from researchers for nanomedicine applications such as drug delivery, diagnostic and imaging, tissue engineering and photodynamic therapy; due to their size, structural properties, and function as an antioxidant [22][23][24][25][26][27]. Gold nanoparticles (AuNPs) have been a great source of interest due to their novel characteristics such as size-related electronic [28], optical (quantum size effect) [29], chemical, and magnetic properties that are potentially useful in biological applications [30][31][32][33].…”