PEGylated Lipova E120 liposomes loaded with celecoxib: in-vitro characterization and enhanced in-vivo anti-inflammatory effects in rat models

Dave, Vivek; Gupta, Ashish; Singh, Priyanka; Tak, Kajal; Sharma, Swapnil

doi:10.1007/s12038-019-9919-x

Cited by 13 publications

(3 citation statements)

References 26 publications

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“…From the frequency range of 4000-400 cm −1 , the spectra was scanned and further advanced ATR correction was used to obtain the spectrum. Fitting of all peaks was executed out with the aid of software named opus (Venkatesh et al 2015;Dave et al 2019).…”

Section: Estimation Of Ph Viscosity Spreadability and Extrudabilitymentioning

confidence: 99%

Herbal ethosomal gel containing luliconazole for productive relevance in the field of biomedicine

et al. 2020

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This study includes development, characterization, and optimization of herbal ethosomal formulation. The aim of the present study is to develop drug loaded ethosomes capped with Azadirachta indica (neem) which, was further incorporated in Carbopol 934 K thereby, resulting in the formation of ethosomal gel. The formulation is aimed to express effective treatment against fungal infection. The build was formulated using drug (Luliconazole), soyalecithin, ethanolic neem extract and propylene glycol. In total nine ethosomal, formulations of distinct concentrations of ingredients were processed, to determine out the optimized formulation among the all. Further the prepared drug loaded ethosomes were subjected to various evaluation parameters like particle size, zeta potential, polydispersity index (PDI) and % entrapment efficiency. For the evaluation of its surface morphology, transmission electron microscopy was executed whereas, atomic force microscopy was carried out which contributes in detail and depth information of surface morphology. For the analysis of thermal behavior Thermal gravimetric analysis graph was obtained for luliconazole, soyalecithin, neem extract, physical mixture and optimized formulation (LF5). Attenuated total internal reflection Fourier transforms infra-red spectroscopy was performed for luliconazole, soyalecithin, neem extract, physical mixture, and optimized formulation (LF5) to examine the interaction between the drug and the excipients. Viscosity, pH, spreadability and extrudability of the ethosomal gel were calculated to determine the suitability of the formulation for topical application. In vitro drug permeation study and antifungal activity was executed out with the aid of Wistar albino rat skin model and tube dilution assay respectively. The complete study wrap up, that this herbal ethosomal approach provides advanced sustained and targeted delivery of luliconazole. On analyzing the results, ethosomal formulation LF5 was found to be optimized one, due to its optimum concentration of soyalecithin (300 mg) and ethanol (35%). Hence it has maximum entrapment efficiency of 86.56 ± 0.74%. Optimum vesicle size, zeta potential, and PDI were found to be 155.30 ± 1.2 nm, − 42.20 ± 0.3 mV, and 0.186 ± 0.07 respectively. In vitro drug permeation study expresses release of 83.45 ± 2.51 in 24 h whereas; the in vivo activity proved that LF5 is more active and effective against Candida parapsilosis in comparison to Aspergillus niger. In the end, it was estimated that ethosomal suspension and lyophilized ethosomal suspension was utmost stable at 4 °C/60 ± 5 RH. The complete study clearly indicates that the buildup of ethosomal formulation with luliconazole and neem extract show synergistic effect thereby, expressing excellent result against the treatment of fungal infection.

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Section: Estimation Of Ph Viscosity Spreadability and Extrudabilitymentioning

confidence: 99%

Herbal ethosomal gel containing luliconazole for productive relevance in the field of biomedicine

et al. 2020

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“…13 Dave et al achieved an improved anti-arthritic activity of celecoxib encapsulated into PEGylated liposomes. 19 Other nano-carriers of celecoxib showed improved cytotoxic, 20 anti-arthritic effect, 10 anti-inflammatory effect 21 and pain management properties. 22 Spanlastics or modified niosomes are novel flexiblewalled nano-vesicular systems that differ from common niosomes in that they contain only non-ionic surfactant, usually Spans, in addition to an edge activator.…”

Section: Introductionmentioning

confidence: 99%

Topical Nano-Vesicular Spanlastics of Celecoxib: Enhanced Anti-Inflammatory Effect and Down-Regulation of TNF-α, NF-кB and COX-2 in Complete Freund’s Adjuvant-Induced Arthritis Model in Rats

Alaaeldin

Abou-Taleb

Mohamad

et al. 2021

IJN

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“…Therefore, how to reduce the adsorption of plasma proteins especially IgG and complement to liposomes is the key to prolong the circulation time of liposomes. In the past decade, among the technologies for inhibiting proteins adsorption, the method to modify the surface of the liposomes with hydrophilic molecules such as poly(ethylene glycol) (PEG) has been the most commonly used. − Progress is made; however, the results vary in different reports. − …”

Section: Introductionmentioning

confidence: 99%

Construction a Long-Circulating Delivery System of Liposomal Curcumin by Coating Albumin

Wei

2020

ACS Omega

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Although the bioavailability and stability of curcumin can be greatly improved by liposomes encapsulation, its application is still limited due to the short circulating time. In this present work, we aim to construct a long-circulating delivery system of liposomal curcumin (Cur-Lips) by coating bovine serum albumin (BSA), namely, BSA-coated liposomal curcumin (BSA-Cur-Lips). The effects of coating albumin on the physicochemical properties of Cur-Lips were investigated. It was found that BSA-Cur-Lips was more spherical, more homogeneous in size, and significantly larger than Cur-Lips. Combining sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), Coomassie bright blue staining, and X-ray photoelectron spectroscopy analysis (XPS), we confirmed that albumin molecules were stably located on the surface of BSA-Cur-Lips. In addition, the impacts of the coating albumin on the Cur-Lips release and phagocytosis by mouse macrophages Raw264.7 in vitro were investigated. We found that no significant initial burst drug release effect was observed for both Cur-Lips and BSA-Cur-Lips and the presence of albumin can enhance the liposome structure stability and slow down the release of Cur. More importantly, the macrophage phagocytosis of Cur-Lips was significantly reduced after coating albumin. In conclusion, coating albumin is a promising approach for developing a long-circulating delivery system of liposomal curcumin, and its properties including low phagocytosis, slow drug release, enhanced stability, and nontoxicity give this system great prospects for practical use.

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PEGylated Lipova E120 liposomes loaded with celecoxib: in-vitro characterization and enhanced in-vivo anti-inflammatory effects in rat models

Cited by 13 publications

References 26 publications

Herbal ethosomal gel containing luliconazole for productive relevance in the field of biomedicine

Herbal ethosomal gel containing luliconazole for productive relevance in the field of biomedicine

Topical Nano-Vesicular Spanlastics of Celecoxib: Enhanced Anti-Inflammatory Effect and Down-Regulation of TNF-α, NF-кB and COX-2 in Complete Freund’s Adjuvant-Induced Arthritis Model in Rats

Construction a Long-Circulating Delivery System of Liposomal Curcumin by Coating Albumin

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