PEGylated dendritic diaminocyclohexyl-platinum (II) conjugates as pH-responsive drug delivery vehicles with enhanced tumor accumulation and antitumor efficacy

Chlorotoxin-Conjugated Multifunctional Dendrimers Labeled with Radionuclide 131I for Single Photon Emission Computed Tomography Imaging and Radiotherapy of Gliomas

“…[39][40][41] In the past decades, many researchers have shown that anticancer drugs or therapeutic genes can be carried by dendrimers for cancer therapy applications. [42][43][44][45][46] Dendrimers can also be attached with targeting ligands and contrast agents for targeted cancer imaging. [47][48][49][50][51][52][53] Recent studies have demonstrated that dendrimers conjugated with radionuclides can be used for cancer imaging; [54][55][56] however, the therapeutic potential of the dendrimer conjugates has not been fully explored.…”

High quality β-FeOOH nanostructures constructed by a biomolecule-assisted hydrothermal approach and their pH-responsive drug delivery behaviors

“…1 Various nanomaterials have been used in drug delivery research fields as they can effectively deliver drugs to target sites and thus increase the therapeutic benefit while minimizing the side effects. [3][4][5] Among these stimuli, pH response has been widely employed in designing novel smart nanomaterials for drug delivery and disease therapy. [3][4][5] Among these stimuli, pH response has been widely employed in designing novel smart nanomaterials for drug delivery and disease therapy.…”

Preclinical studies of dendrimer prodrugs

“…The anticancer Pt-containing compound could therefore be released from the dendrimer at low pH. The PEGylated DACHPt--dendrimer conjugates displayed reduced toxicity and improved anticancer effects compared with free oxaliplatin [44]. Zhou et al described a polylysine dendrimer modified with CPT, which is an anticancer drug that inhibits topoisomerase I.…”