Preclinical studies of dendrimer prodrugs

Kojima, Chie

doi:10.1517/17425255.2015.1052404

Cited by 9 publications

(3 citation statements)

References 80 publications

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“…Moreover, one study compared the PAMAM dendrimers’ suitability with DOTAP liposomes for topical delivery of siRNA against TNF-α. The results showed that phenotypic and histopathological features were improved, and IL-6, TNF-α, IL-17, and IL-22 levels decreased in the dendritic plexus and liposome treatment groups compared to the imiquimod group ( 58 ).…”

Section: Promising Strategies: Advanced Topical Nanocarrier Systemsmentioning

confidence: 98%

Exploration of and insights into advanced topical nanocarrier systems for the treatment of psoriasis

Zhang

Hong

Sun³

et al. 2022

Front. Med.

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Psoriasis is a chronic inflammatory skin disease with an underlying autoimmune pathogenesis that has brought great distress to patients. Current treatment options include topical therapy, systemic therapy, and phototherapy. By disrupting the stratum corneum, nanocarriers have unique advantages in allowing drug carriers to be tailored to achieve targeted drug delivery, improve efficacy, and minimize adverse effects. Furthermore, despite their limited success in market translatability, nanocarriers have been extensively studied for psoriasis, owing to their excellent preclinical results. As topical formulations are the first line of treatment, utilize the safest route, and facilitate a targeted approach, this study, we specifically describes the management of psoriasis using topical agents in conjunction with novel drug delivery systems. The characteristics, advantages, weaknesses, and mechanisms of individual nanocarriers, when applied as topical anti-psoriatic agents, were reviewed to distinguish each nanocarrier.

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Section: Promising Strategies: Advanced Topical Nanocarrier Systemsmentioning

confidence: 98%

Exploration of and insights into advanced topical nanocarrier systems for the treatment of psoriasis

Zhang

Hong

Sun³

et al. 2022

Front. Med.

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“…Dendrimers are three-dimensional spherical chemical structures with high monodispersity, dimensional adjustability and surface functionalization [95] , [96] , [97] , [98] . These unique features enable dendrimers to link, coordinate, or encapsulate therapeutic drugs (as shown in Fig.…”

Section: Dendrimer-based Prodrugsmentioning

confidence: 99%

Glucocorticoids-based prodrug design: Current strategies and research progress

Liu,

Ji,

Xiao

et al. 2024

Asian Journal of Pharmaceutical Sciences

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“…The rapid, efficient preparation of high-generation dendrimers is important to the development of macromolecular therapeutics, − diagnostic agents, − catalysts, − and encapsulants. − Dendrimers are a particularly attractive platform for macromolecular therapeutics owing to their precisely defined molecular structure, which can be tuned at the core, interior, and periphery. − However, the synthesis of monodisperse high-generation dendrimers, which are critical to many biomedical applications, remains a major challenge . Divergent dendrimer synthesis methods commonly suffer from incomplete conversion or side reactions at the dendrimer periphery, while convergent methods often suffer from poor yields or slow reaction times when high-generation dendrimers are needed.…”

Section: Introductionmentioning

confidence: 99%

Rapid Synthesis of Functionalized High-Generation Polyester Dendrimers via Strain-Promoted Alkyne–Azide Cycloaddition

McNelles

Adronov

2017

Macromolecules

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Preparation of structurally perfect high-generation dendrimer libraries with different peripheral groups is challenging as divergent synthesis introduces peripheral defects and convergent synthesis leads to low yields. Here, we prepare a third-generation polyester dendron based on the bisMPA monomer structure, having eight peripheral azide functionalities, as an “inner” dendron. We also prepare a series of low-generation “outer” dendrons (G2 and G3) with various peripheral groups, including aromatic, aliphatic, and polar structures, each having a single dibenzoazacyclooctyne (DIBAC) at the core. Efficient strain-promoted azide–alkyne cycloaddition (SPAAC) enables quantitative coupling between the outer and inner dendrons, producing high-generation (G5 and G6) dendrimers in a single coupling step. Characterization by NMR and mass spectrometry shows that the coupling products are structurally perfect. Using this strategy, we prepared a small dendrimer library that includes the first high-generation monodisperse peripherally PEGylated dendrimers as well as a structure bearing bulky protected amino acids at its periphery. This general strategy allows for rapid, efficient, and quantitative preparation of high-generation dendrimers with a variety of peripheral and core functional groups, starting from small, easily prepared fragments.

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Preclinical studies of dendrimer prodrugs

Cited by 9 publications

References 80 publications

Exploration of and insights into advanced topical nanocarrier systems for the treatment of psoriasis

Exploration of and insights into advanced topical nanocarrier systems for the treatment of psoriasis

Glucocorticoids-based prodrug design: Current strategies and research progress

Rapid Synthesis of Functionalized High-Generation Polyester Dendrimers via Strain-Promoted Alkyne–Azide Cycloaddition

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