Peganum Harmala

El-Rifaie, M. El-Saad

doi:10.1111/j.1365-4362.1980.tb00305.x

Cited by 31 publications

(4 citation statements)

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“…It has antibacterial activity against drug-resistant bacteria and is used in the treatment of syphilis in India, fever in North Africa, hysteria, neuralgia, Parkinson’s disease, prolapsed uterus, rheumatism, asthma, and eye irritation. P. harmala is an abortifacient and is effective against protozoa including malaria (Al-Sharma et al 1981; Ahmad et al 1992; El-Rifaie 1980). …”

Section: Resultsmentioning

confidence: 99%

An ethnoveterinary study of medicinal plants in treatment of diseases and syndromes of herd dog in southern regions of Ilam province, Iran

Bahmani

Eftekhari

2012

Comp Clin Pathol

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This paper describes a selection of the ethnoveterinary medicines used for herd dogs in the southern regions of Ilam province, Iran. Traditional botanical medicine is the primary mode of healthcare for most of the rural population in Ilam province. In this study, a questionnaire was distributed among 45 residential areas in 22 rural zones of the southern areas of Ilam province. The objective of this study was the recognition of natural medicinal methods using medicinal plants, and the classification of ethnoveterinary applications and collection of domestic science. Twenty-two medicinal plants from 16 families were identified. The main application of these plants was for the detection and treatment of digestive disorders using Citrullus colocynthis, Aristolochia clematis, Scrophularia deserti, Quercus brantii, Ceracus microcarpa, Echium strigosa, Pistacia atlantica, and Pistacia khinjuk which have been applied using Euphurbia graminifolius, Peganum harmala, Salsola rigida, Artemisia herba-alba, Amygdalus arabica, jolbak of salt water, Peganum harmala L., and Nicotina tabacum for external and internal parasite disorders. S. deserti for ophthalmic disorders, and P. atlantica, P. khinjuk, and Q. brantii for respiratory disorders were applied. The present study confirmed the traditional medical effects of some plants and revealed the unique medical effects of other plants, which if recognized could be useful in the creation of new ideas and increasing knowledge for the modern pharmaceutical industry. Since very few clinical trials have been conducted on plants native to Ilam province, it is necessary that more research be conducted to ensure that labeled and standardized products are introduced for human consumption.

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Section: Resultsmentioning

confidence: 99%

An ethnoveterinary study of medicinal plants in treatment of diseases and syndromes of herd dog in southern regions of Ilam province, Iran

Bahmani

Eftekhari

2012

Comp Clin Pathol

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“…A clinical trial performed in Egypt evaluated the antibacterial and antiprotozoal activity of P. harmala in multiple skin conditions [ 112 ]. One hundred and eleven patients with multiple or bilateral lesions were randomly selected and followed for four weeks.…”

Section: Health-promoting Effects Evidenced By Clinical Trialsmentioning

confidence: 99%

Peganum spp.: A Comprehensive Review on Bioactivities and Health‐Enhancing Effects and Their Potential for the Formulation of Functional Foods and Pharmaceutical Drugs

Sharifi‐Rad

Quispe

Herrera‐Bravo

et al. 2021

Oxidative Medicine and Cellular Longevity

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The genus Peganum includes four species widely distributed in warm temperate to subtropical regions from the Mediterranean to Mongolia as well as certain regions in America. Among these species, Peganum harmala L., distributed from the Mediterranean region to Central Asia, has been studied and its phytochemical profile, traditional folk use, and application in pharmacological and clinical trials are well known. The review is aimed at presenting an insight into the botanical features and geographical distribution of Peganum spp. along with traditional folk uses. This manuscript also reviews the phytochemical profile of Peganum spp. and its correlation with biological activities evidenced by the in vitro and in vivo investigations. Moreover, this review gives us an understanding of the bioactive compounds from Peganum as health promoters followed by the safety and adverse effects on human health. In relation to their multipurpose therapeutic properties, various parts of this plant such as seeds, bark, and roots present bioactive compounds promoting health benefits. An updated search (until December 2020) was carried out in databases such as PubMed and ScienceDirect. Chemical studies have presented beta-carboline alkaloids as the most active constituents, with harmalol, harmaline, and harmine being the latest and most studied among these naturally occurring alkaloids. The Peganum spp. extracts have shown neuroprotective, anticancer, antimicrobial, and antiviral effects. The extracts are also found effective in improving respiratory disorders (asthma and cough conditions), dermatoses, and knee osteoarthritis. Bioactivities and health-enhancing effects of Peganum spp. make it a potential candidate for the formulation of functional foods and pharmaceutical drugs. Nevertheless, adverse effects of this plant have also been described, and therefore new bioproducts need to be studied in depth. In fact, the design of new formulations and nanoformulations to control the release of active compounds will be necessary to achieve successful pharmacological and therapeutic treatments.

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“…Peganum harmala, that had been used in traditional medicine as an anti-inflammatory and hypothermia agent [15] contain about 2-6% pharmacological active alkaloids [16], which are mostly b-carbolines such as Harman, Harmine, Harmaline and Harmalol [17]. Harmine, a bcarboline alkaloids originally isolated from the seeds of Peganum harmala possess a broad range of pharmacological activities, such as behavioral effects [18].…”

Section: Introductionmentioning

confidence: 99%

Harmine, a Novel DNA Methyltransferase 1 Inhibitor in the Leukemia Cell Line

Oodi

Norouzi

Amirizadeh

et al. 2017

Indian J Hematol Blood Transfus

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DNA methylation followed by tumor suppressor gene repression plays a critical role in the leukemia development. So, DNA methyl transferase inhibitors have great importance in treatment of theses malignancies. Harmine, A beta carboline alkaloid derivative of Peganum harmala, had shown anti- proliferative effects on leukemic cell line. This study aimed to evaluate the effect of Harmine on DNMT1 (DNA methyl transferase 1) expression in a leukemic cell line. Cell proliferation and cell cycle analysis were studied in NB4 cell line after treatment with Harmine for 72 h. DNMT1 expression in treated cells was analyzed by real time PCR. Tumor suppressor gene hypometylation and reactivation was evaluated via MSP analysis and also real time PCR. Harmine reduced cell proliferation in NB4 cell line in a time and dose-dependent manner. 102 µg/ml of Harmine was increased amount of cells in G1 Phase of cell cycle ( < 0.05). Anti proliferative doses of Harmine, has suppressed DNMT1 gene in NB4 cell line. Down-regulated DNMT1 induced p15 tumor suppressor promoter hypomethylation and reactivation. Our data indicate that Harmine can be considered as a potential treatment for AML (Acute Myeloid Leukemia), and future studies are required to test the clinical efficacy of Harmine-whether used as a single agent or as an adjuvant-for AML treatment.

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Peganum Harmala

Abstract: The extract of Peganum harmala (Rutaceae) was used topically to treat certain dermatoses of inflammatory nature. Results were encouraging and proved the antibacterial, antifungal, antipruritic and probably antiprotozoal effects of the extract.

Cited by 31 publications

References 1 publication

An ethnoveterinary study of medicinal plants in treatment of diseases and syndromes of herd dog in southern regions of Ilam province, Iran

An ethnoveterinary study of medicinal plants in treatment of diseases and syndromes of herd dog in southern regions of Ilam province, Iran

Peganum spp.: A Comprehensive Review on Bioactivities and Health‐Enhancing Effects and Their Potential for the Formulation of Functional Foods and Pharmaceutical Drugs

Harmine, a Novel DNA Methyltransferase 1 Inhibitor in the Leukemia Cell Line

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