PEG‐Biscyanoacrylate Crosslinker for Octyl Cyanoacrylate Bioadhesive

Abstract

PEG400 (polyethylene glycol, MW 400) biscyanoacrylate is synthesized and copolymerized with 2-octyl cyanoacrylate for potential use as bioadhesive. PEG400 biscyanoacrylate is synthesized from the esterification of anthracenyl cyanoacrylic acid where the anthracene unit serves as vinyl-protecting group. Copolymerization increases the plasticity, mechanical strength, and resilience of the resulted polymer as determined by dynamic mechanical analysis. Peeling test confirms its superior bioadhesive properties. Surface morphology is characterized by SEM imaging. The formulations are cytocompatible and safe. This cyanoacrylate composition may provide improved bioadhesive cyanoacrylates.

Polymerization Enhancers for Cyanoacrylate Skin Adhesive

“…The results are similar to the experimental observations we had previously on the effect of PEG‐biscyanoacrylate crosslinker for OCA and Dermaflex. [ 32 ] Upon copolymerization with the crosslinker, the OCA shows more than 50% increased peeling strength than the commercial Dermaflex.…”

“…Similarly, another piece of skin of the same dimension was prepared with OCA and immediately placed in contact and press by using two fingers for 30 s. It was allowed to stand for 1, 6, and 24 h, after which the peeling force was measured using a material tester. [ 32 ] The loose portion of the first skin piece was adhered to the grip of the material tester. The second skin piece was tightly clipped to the bottom.…”

Bio-macromolecular design roadmap towards tough bioadhesives

“…For instance, a PEG biscyanoacrylate-based bioadhesive hydrogel was used as a crosslinker in an octyl cyanoacrylate adhesive polymer. 161 Here, anthracenyl cyanoacrylic acid was esterified while anthracene protected the vinyl groups. This copolymerization resulted in a cytocompatible strong and adhesive (over 200 kPa peel-off strength) material.…”